{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T10:10:11Z","timestamp":1755857411378,"version":"3.44.0"},"reference-count":13,"publisher":"SMC Media","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>It is rare for IgM multiple myeloma (MM) and mantle cell lymphoma (MCL) to coexist. Furthermore, it is challenging to demonstrate if there are two distinct types of neoplasia or if plasma cell differentiation of MCL is present. We discuss the case of a patient concomitantly diagnosed with MCL and IgM MM, and the subsequent diagnostic and management difficulties, and the positive treatment outcome.<\/jats:p>","DOI":"10.12890\/2022_003463","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T03:30:52Z","timestamp":1657164652000},"source":"Crossref","is-referenced-by-count":0,"title":["The Diagnostic and Treatment Challenges of Concomitant Mantle Cell Lymphoma and IgM Myeloma"],"prefix":"10.12890","volume":"9","author":[{"given":"Dhairya","family":"Gor","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Jersey Shore Medical Center, Neptune, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohan","family":"Mehta","sequence":"additional","affiliation":[{"name":"Hematology Oncology Department, Jersey Shore Medical Center, Neptune, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Hematology Oncology Department, Jersey Shore Medical Center, Neptune, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evgeniya","family":"Angelova","sequence":"additional","affiliation":[{"name":"Pathology Department, Jersey Shore Medical Center, Neptune, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2022,7,7]]},"reference":[{"key":"10.12890\/2022_003463_ref1","doi-asserted-by":"crossref","unstructured":"<li>Sikuyayenga MJ, Reeder CB, Mikhael JR. New diagnosis of multiple myeloma in a patient with mantle cell lymphoma: shared genetic factors or simple coincidence? <em>Leuk Res Rep<\/em> 2012;<strong>1<\/strong>(1):7. doi:10.1016\/J.LRR.2012.09.003<\/li>","DOI":"10.1016\/j.lrr.2012.09.003"},{"key":"10.12890\/2022_003463_ref2","doi-asserted-by":"crossref","unstructured":"<li>Young KH, Chan WC, Fu K, Iqbal J, Sanger WG, Ratashak A, et al. Mantle cell lymphoma with plasma cell differentiation.<em>Am J Surg Pathol<\/em> 2006;<strong>30<\/strong>(8):954\u2013961. doi:10.1097\/00000478-200608000-00004<\/li>","DOI":"10.1097\/00000478-200608000-00004"},{"key":"10.12890\/2022_003463_ref3","doi-asserted-by":"crossref","unstructured":"<li>Thieblemont C, Nasser V, Felman P, Leroy K, Gazzo S, Callet-Bauchu E, et al. Small lymphocytic lymphoma, marginal zone B-cell lymphoma, and mantle cell lymphoma exhibit distinct gene-expression profiles allowing molecular diagnosis. <em>Blood<\/em> 2004;<strong>103<\/strong>(7):2727\u20132737. doi:10.1182\/blood-2003-06-2160<\/li>","DOI":"10.1182\/blood-2003-06-2160"},{"key":"10.12890\/2022_003463_ref4","doi-asserted-by":"crossref","unstructured":"<li>Visco C, Hoeller S, Malik JT, Xu-Monette ZY, Wiggins ML, Liu J, et al. Molecular characteristics of mantle cell lymphoma presenting with clonal plasma cell component.<em> Am J Surg Pathol<\/em> 2011;<strong>35<\/strong>(2):177\u2013189. doi:10.1097\/PAS.0B013E3182049A9C<\/li>","DOI":"10.1097\/PAS.0b013e3182049a9c"},{"key":"10.12890\/2022_003463_ref5","doi-asserted-by":"crossref","unstructured":"<li>Hummel M, Tamaru JI, Kalvelage B, Stein H. Mantle cell (previously centrocytic) lymphomas express V(H) genes with no or very little somatic mutations like the physiologic cells of the follicle mantle. <em>Blood<\/em> 1994;<strong>84<\/strong>(2):403\u2013407. doi:10.1182\/blood.v84.2.403.403<\/li>","DOI":"10.1182\/blood.V84.2.403.403"},{"key":"10.12890\/2022_003463_ref6","doi-asserted-by":"crossref","unstructured":"<li>Gradowski JF, Jaffe ES, Warnke RA, Pittaluga S, Surti U, Gole LA, et al. Follicular lymphomas with plasmacytic differentiation include two subtypes. <em>Mod Pathol<\/em> 2010;<strong>23<\/strong>(1):71\u201379. doi:10.1038\/modpathol.2009.146<\/li>","DOI":"10.1038\/modpathol.2009.146"},{"key":"10.12890\/2022_003463_ref7","doi-asserted-by":"crossref","unstructured":"<li>Keith TA, Cousar JB, Glick AD, Vogler LB, Collins RD. Plasmacytic differentiation in follicular center cell (FCC) lymphomas. <em>Am J Clin Pathol<\/em> 1985;<strong>84<\/strong>(3):283\u2013290. doi:10.1093\/ajcp\/84.3.283<\/li>","DOI":"10.1093\/ajcp\/84.3.283"},{"key":"10.12890\/2022_003463_ref8","doi-asserted-by":"crossref","unstructured":"<li>Montes-Moreno S, Gonzalez-Medina AR, Rodriguez-Pinilla SM, Maestre L, Sanchez-Verde L, Roncador G, et al. Aggressive large B-cell lymphoma with plasma cell differentiation: immunohistochemical characterization of plasmablastic lymphoma and diffuse large B-cell lymphoma with partial plasmablastic phenotype. <em>Haematologica<\/em> 2010;<strong>95<\/strong>(8):1342\u20131349. doi:10.3324\/haematol.2009.016113<\/li>","DOI":"10.3324\/haematol.2009.016113"},{"key":"10.12890\/2022_003463_ref9","doi-asserted-by":"crossref","unstructured":"<li>Fonseca R, Bergsagel PL, Drach J, Shaughnessy J, Gutierrez N, Stewart AK, et al. International Myeloma Working Group molecular classification of multiple myeloma: spotlight review. <em>Leukemia<\/em> 2009;<strong>23<\/strong>(12):2210\u20132221. doi:10.1038\/leu.2009.174","DOI":"10.1038\/leu.2009.174"},{"key":"10.12890\/2022_003463_ref10","doi-asserted-by":"crossref","unstructured":"<li>Maddocks K. Update on mantle cell lymphoma. <em>Blood<\/em> 2018;<strong>132<\/strong>(16):1647\u20131656. doi:10.1182\/BLOOD-2018-03-791392<\/li>","DOI":"10.1182\/blood-2018-03-791392"},{"key":"10.12890\/2022_003463_ref11","doi-asserted-by":"crossref","unstructured":"<li>Jain P, Wang M. Mantle cell lymphoma: 2019 update on the diagnosis, pathogenesis, prognostication, and management. <em>Am J Hematol<\/em> 2019;<strong>94<\/strong>(6):710\u2013725. doi:10.1002\/AJH.25487<\/li>","DOI":"10.1002\/ajh.25487"},{"key":"10.12890\/2022_003463_ref12","doi-asserted-by":"crossref","unstructured":"<li>Eskelund CW, Dahl C, Hansen JW, Westman M, Kolstad A, Pedersen LB, et al. TP53 mutations identify younger mantle cell lymphoma patients who do not benefit from intensive chemoimmunotherapy. <em>Blood<\/em> 2017;<strong>130<\/strong>(17):1903\u20131910. doi:10.1182\/blood-2017-04-779736<\/li>","DOI":"10.1182\/blood-2017-04-779736"},{"key":"10.12890\/2022_003463_ref13","doi-asserted-by":"crossref","unstructured":"<li>Narkhede M, Mehta A, Ansell SM, Goyal G. CAR T-cell therapy in mature lymphoid malignancies: clinical opportunities and challenges.<em> Ann Transl Med<\/em> 2021;<strong>9<\/strong>(12):1036\u20131036. doi:10.21037\/atm-20-5546<\/li>","DOI":"10.21037\/atm-20-5546"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3463\/3164","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3463\/3165","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3463\/3165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T09:31:44Z","timestamp":1755855104000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/3463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,7]]},"references-count":13,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.12890\/2022_003463","relation":{"has-manifestation":[{"id-type":"other","id":"1-88-3463-g3164","asserted-by":"subject"},{"id-type":"other","id":"1-88-3463-g3165","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-88","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2022,7,7]]},"article-number":"10"}}