{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:21:44Z","timestamp":1779927704528,"version":"3.53.1"},"reference-count":0,"publisher":"SMC Media","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Graves\u2019 disease is an autoimmune disorder that results in hyperthyroidism, caused by autoantibodies to the thyrotropin receptor (TRAbs) stimulating thyroid hormone synthesis, giving rise to a variety of systemic manifestations such as goitre, dermatopathy and orbitopathy.\u00a0 The authors present the case of a 28-year-old man admitted to hospital for a 3-week history of fatigue, shortness of breath, palpitations and diffuse goitre, after recent mild SARS-CoV-2 infection. Laboratory investigation revealed hyperthyroidism with TRAbs elevation. Thyroid ultrasound confirmed a diffusely heterogeneous and irregular thyroid gland and a nodular image below the sternal notch. Thyroid scintigraphy excluded the nodule and confirmed a Graves\u2019 disease pattern. Following the initiation of methimazole, the patient had complete resolution of symptoms and normalization of thyroid values. The results suggest a possible association between Graves\u2019 disease and SARS-CoV-2 infection acting as a trigger. Graves\u2019 disease is an important differential diagnosis to keep in mind when patients present with hyperthyroidism after COVID-19 disease.<\/jats:p>","DOI":"10.12890\/2022_003470","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T01:53:16Z","timestamp":1658713996000},"source":"Crossref","is-referenced-by-count":6,"title":["Graves\u2019 Disease Caused by SARS-CoV-2 Infection"],"prefix":"10.12890","volume":"9","author":[{"given":"Bruno","family":"Sousa","sequence":"additional","affiliation":[{"name":"Internal Medicine Department , Hospital Garcia de Orta, Almada, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina","family":"Pestana Santos","sequence":"additional","affiliation":[{"name":"Internal Medicine Department , Hospital Garcia de Orta, Almada, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Gon\u00e7alves Ferreira","sequence":"additional","affiliation":[{"name":"Endocrinology Department, Hospital Garcia de Orta, Almada, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago","family":"Judas","sequence":"additional","affiliation":[{"name":"Internal Medicine Department , Hospital Garcia de Orta, Almada, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10397","published-online":{"date-parts":[[2022,7,20]]},"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3470\/3176","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3470\/3177","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3470\/3177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T09:31:26Z","timestamp":1755855086000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/3470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,20]]},"references-count":0,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.12890\/2022_003470","relation":{"has-manifestation":[{"id-type":"other","id":"1-88-3470-g3176","asserted-by":"subject"},{"id-type":"other","id":"1-88-3470-g3177","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-88","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"value":"2284-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,20]]},"article-number":"5"}}