{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T20:55:51Z","timestamp":1778878551068,"version":"3.51.4"},"reference-count":10,"publisher":"SMC Media","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Acquired amegakaryocytic thrombocytopenia (AAMT) is a rare disorder of the bone marrow characterized by a lack of megakaryocytes and preservation of other cell lines. It can occur due to an intrinsic stem cell defect or secondary to viral infections, autoimmune disorders, lymphoproliferative disorders or environmental toxins. With time, it can progress to aplastic anaemia (AA) and can have a poor prognosis. No standard guidelines exist for the treatment of AAMT progressing to AA. Herein, we report a rare case of AAMT leading to AA and review the handful of cases previously published in the literature.<\/jats:p>","DOI":"10.12890\/2022_003479","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T03:44:40Z","timestamp":1662349480000},"source":"Crossref","is-referenced-by-count":3,"title":["Acquired Amegakaryocytic Thrombocytopenia Progressingto Aplastic Anaemia"],"prefix":"10.12890","volume":"9","author":[{"given":"Syed Ather","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Rochester General Hospital, Rochester, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huda","family":"Fatima","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Mercy Health St. Vincent Medical Center, Toledo, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hafsa","family":"Faisal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Rochester General Hospital, Rochester, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meenakshi","family":"Bansal","sequence":"additional","affiliation":[{"name":"Department of Pathology, Rochester General Hospital, Rochester, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2022,9,5]]},"reference":[{"key":"10.12890\/2022_003479_ref1","doi-asserted-by":"crossref","unstructured":"<li>Roy AM, Konda M, Sidarous GK, Atwal D, Schichman SA, Kunthur A. Acquired amegakaryocytic thrombocytopenia misdiagnosed as immune thrombocytopenia: a case report. <em>Perm J<\/em> 2020;<strong>24<\/strong>:1\u20133. doi:10.7812\/TPP\/19.203.<\/li>","DOI":"10.7812\/TPP\/19.203"},{"key":"10.12890\/2022_003479_ref2","doi-asserted-by":"crossref","unstructured":"<li>Levy I, Laor R, Jiries N, Bejar J, Polliack A, Tadmor T. Amegakaryocytic thrombocytopenia and subsequent aplastic anemia associated with apparent Epstein-Barr virus infection. <em>Acta Haematol<\/em> 2018;<strong>139<\/strong>(1):7\u201311. doi:10.1159\/000484595.<\/li>","DOI":"10.1159\/000484595"},{"key":"10.12890\/2022_003479_ref3","unstructured":"<li>Hoffman R. Acquired pure amegakaryocytic thrombocytopenic purpura. <em>Semin Hematol<\/em> 1991;<strong>28<\/strong>(4):303\u2013312.<\/li>"},{"key":"10.12890\/2022_003479_ref4","doi-asserted-by":"crossref","unstructured":"<li>Novotn\u00fd JP, K\u00f6hler B, Max R, Egerer G. Acquired amegakaryocytic thrombocytopenic purpura progressing into aplastic anemia. <em>Prague Med Rep<\/em> 2018;<strong>118<\/strong>(4):147\u2013155.<\/li>","DOI":"10.14712\/23362936.2017.16"},{"key":"10.12890\/2022_003479_ref5","doi-asserted-by":"crossref","unstructured":"<li>Simkins A, Maiti A, Short NJ, Jain N, Popat U, Patel KP, et al. Acquired amegakaryocytic thrombocytopenia and red cell aplasia in a patient with thymoma progressing to aplastic anemia successfully treated with allogenic stem cell transplantation. <em>Hematol Oncol Stem Cell Ther<\/em> 2019;<strong>12<\/strong>(2):115\u2013118.<\/li>","DOI":"10.1016\/j.hemonc.2017.09.001"},{"key":"10.12890\/2022_003479_ref6","doi-asserted-by":"crossref","unstructured":"<li>Stoll DB, Stuart B, Pasquale D, Murphy S. 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Aplastic anemia occurring as amegakaryocytic thrombocytopenia with and without an inhibitor of granulopoiesis. <em>Am J Hematol<\/em> 1985;<strong>18<\/strong>(3):251\u2013254. doi:10.1002\/ajh.2830180305.<\/li>","DOI":"10.1002\/ajh.2830180305"},{"key":"10.12890\/2022_003479_ref9","doi-asserted-by":"crossref","unstructured":"<li>King JA, Elkhalifa MY, Latour LF. Rapid progression of acquired amegakaryocytic thrombocytopenia to aplastic anemia. <em>South Med J<\/em> 1997;<strong>90<\/strong>(1):91\u201394. doi:10.1097\/00007611-199701000-00024.<\/li>","DOI":"10.1097\/00007611-199701000-00024"},{"key":"10.12890\/2022_003479_ref10","doi-asserted-by":"crossref","unstructured":"<li>Tu X, Xue A, Wu S, Jin M, Zhao P, Zhang H. Case report: successful avatrombopag treatment for two cases of anti-PD-1 antibody-induced acquired amegakaryocytic thrombocytopenia. <em>Front Pharmacol<\/em> 2022;<strong>12<\/strong>:795884. doi:10.3389\/fphar.2021.795884.<\/li>","DOI":"10.3389\/fphar.2021.795884"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3479\/3213","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3479\/3214","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3479\/3214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T14:05:20Z","timestamp":1755785120000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/3479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,5]]},"references-count":10,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.12890\/2022_003479","relation":{"has-manifestation":[{"id-type":"other","id":"1-90-3479-g3213","asserted-by":"subject"},{"id-type":"other","id":"1-90-3479-g3214","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-90","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"value":"2284-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,5]]},"article-number":"3"}}