{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T14:40:05Z","timestamp":1755787205849,"version":"3.44.0"},"reference-count":10,"publisher":"SMC Media","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Clostridioides difficile infection (CDI) commonly presents with diarrhoea, colitis, and in more severe cases, toxic megacolon. Extraintestinal Clostridioides difficile infection (EI CDI) is rarely reported. Intraabdominal abscesses are the most commonly reported EI CDI presentation. EI CDI-associated bacteraemia, as well as bone, lung, and even intracranial infections have been reported in the literature. EI CDI is usually seen in patients with multiple comorbidities. Due to the rarity of cases, no clear treatment guidelines exist, but metronidazole and vancomycin have been primarily used to treat EI CDI and additional antibiotics have been used for treatment when the isolates are polymicrobial. We report a case of a patient with significant comorbidities who developed EI CDI following acute ruptured appendicitis. She was successfully treated with drainage of abscess and intravenous metronidazole followed by oral metronidazole.<\/jats:p>","DOI":"10.12890\/2022_003489","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T04:04:59Z","timestamp":1663128299000},"source":"Crossref","is-referenced-by-count":0,"title":["Treatment of Extra-Intestinal Clostridioides difficile Abscess following Acute Appendicitis"],"prefix":"10.12890","volume":"9","author":[{"given":"Tulika","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Illinois College of Medicine at Peoria, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moni","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Illinois College of Medicine at Peoria, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharjeel","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Illinois College of Medicine at Peoria, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2022,9,14]]},"reference":[{"key":"10.12890\/2022_003489_ref1","doi-asserted-by":"crossref","unstructured":"<li>Guh AY, Kutty PK. 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Extraintestinal Clostridioides difficile infections: a single-center experience. <em>Mayo Clin<\/em> Proc 2014;<strong>89<\/strong>:1525\u20131536.<\/li>","DOI":"10.1016\/j.mayocp.2014.07.012"},{"key":"10.12890\/2022_003489_ref8","doi-asserted-by":"crossref","unstructured":"<li>Kantamaneni VK, Gurram KC, Kulkarni A. Clostridioides difficile extraintestinal abscess: a rare complication. <em>Brit Med J Case Rep<\/em> 2017 May:bcr2017219957. <\/li>","DOI":"10.1136\/bcr-2017-219957"},{"key":"10.12890\/2022_003489_ref9","doi-asserted-by":"crossref","unstructured":"<li>Zheng L, Citron DM, Genheimer CW, Sigmon SF, Carmon RJ, Lyerly DM, et al. Molecular characterization and antimicrobial susceptibilities of extra-intestinal Clostridioides difficile isolates. <em>Anaerobe<\/em> 2007;<strong>13<\/strong>:114\u2013120.<\/li>","DOI":"10.1016\/j.anaerobe.2007.04.001"},{"key":"10.12890\/2022_003489_ref10","doi-asserted-by":"crossref","unstructured":"<li>Huang H, Weintraub A, Fang H, Nord CE. 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