{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T02:10:54Z","timestamp":1755828654134,"version":"3.44.0"},"reference-count":8,"publisher":"SMC Media","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Introduction: We describe an unusual case of metastatic melanoma of the brain with an unknown primary site during pregnancy. Case Description: A 35-year-old woman in the third trimester of pregnancy presented with ataxia, nausea, vomiting, headaches and diplopia. CT of the brain revealed a hyper-attenuating 2.1 cm mass in the fourth ventricle with mild obstructive hydrocephalus. A healthy newborn was delivered by urgent caesarean section. Craniotomy and resection of the brain lesion confirmed melanoma. Pathology of the placenta reported a \u2018focal nest of melanocytes identified in intervillous space\u2019. Discussion: Brain and maternal placenta pathology findings were consistent with melanoma, making this case relevant because of the possibility of metastatic melanoma in a fetus. Conclusion: Epidemiological data on congenital and infantile melanoma are scarce. Also, there is no database for long-term follow-up of children born to pregnant mothers with metastatic melanoma. Delayed presentation of melanoma in the child cannot be ruled out.<\/jats:p>","DOI":"10.12890\/2022_003490","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T03:13:48Z","timestamp":1664421228000},"source":"Crossref","is-referenced-by-count":0,"title":["An Unusual Case of Malignant Melanoma with Metastasis to the Placenta During Pregnancy"],"prefix":"10.12890","volume":"9","author":[{"given":"Kenny","family":"Garcia-Ramiu","sequence":"additional","affiliation":[{"name":"Internal Medicine Residency Program, Norton Community Hospital, Norton, Virginia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Mohsin","sequence":"additional","affiliation":[{"name":"Internal Medicine Residency Program, Norton Community Hospital, Norton, Virginia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Ikeguchi","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology, Oklahoma University Stephenson Cancer Center, Oklahoma City, Oklahoma, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Newberry","sequence":"additional","affiliation":[{"name":"Internal Medicine Residency Program, Norton Community Hospital, Norton, Virginia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"key":"10.12890\/2022_003490_ref1","doi-asserted-by":"crossref","unstructured":"<li>Johnson JD, Young B. Demographics of brain metastasis. <em>Neurosurg Clin N Am<\/em> 1996 Jul;<strong>7<\/strong>(3):337\u2013344. PMID: 8823767.<\/li>","DOI":"10.1016\/S1042-3680(18)30365-6"},{"key":"10.12890\/2022_003490_ref2","doi-asserted-by":"crossref","unstructured":"<li>Proboka G, Tilgase A, Isajevs S, Rasa A, Alberts P. Melanoma unknown primary brain metastasis treatment with ECHO-7 oncolytic virus Rigvir: a case report. <em>Front Oncol<\/em> 2018 Feb 26;<strong>8<\/strong>:43. doi: 10.3389\/fonc.2018.00043. Erratum in: <em>Front Oncol<\/em> 2018 May 18;<strong>8<\/strong>:172. PMID: 29535971; PMCID: PMC5834433.<\/li>","DOI":"10.3389\/fonc.2018.00043"},{"key":"10.12890\/2022_003490_ref3","unstructured":"<li>Ward WH, Lambreton F, Goel N, Yu JQ, Farma JM. Clinical presentation and staging of melanoma. In: Ward WH, Farma JM, editors. Cutaneous melanoma: etiology and therapy <sup>[Internet]<\/sup>. 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PMID: 25737403.<\/li>","DOI":"10.1002\/cncr.29325"},{"key":"10.12890\/2022_003490_ref6","doi-asserted-by":"crossref","unstructured":"<li>Marcellini M, De Luca N, Riccioni T, Ciucci A, Orecchia A, Lacal PM, et al. Increased melanoma growth and metastasis spreading in mice overexpressing placenta growth factor. <em>Am J Pathol<\/em> 2006;<strong>169<\/strong>(2):643\u2013654. doi: 10.2353\/ajpath.2006.051041<\/li>","DOI":"10.2353\/ajpath.2006.051041"},{"key":"10.12890\/2022_003490_ref7","doi-asserted-by":"crossref","unstructured":"<li>Alexander A, Samlowski WE, Grossman D, Bruggers CS, Harris RM, Zone JJ, et al. Metastatic melanoma in pregnancy: risk of transplacental metastases in the infant.<em> J Clin Oncol<\/em> 2003 Jun 1;<strong>21<\/strong>(11):2179\u20132186. doi: 10.1200\/JCO.2003.12.149. Erratum in: <em>J Clin Oncol<\/em> 2010 Aug 1;<strong>28<\/strong>(22):3670. 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