{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T04:48:22Z","timestamp":1767156502496,"version":"3.44.0"},"reference-count":10,"publisher":"SMC Media","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Introduction: Delayed diagnosis of intravascular large B-cell lymphoma (IVLBCL) is associated with a poor prognosis, making early diagnosis and treatment essential. However, early diagnosis remains challenging.\u00a0 Case description: Here we present the case of a 75-year-old man with fever of unknown origin, in whom random skin biopsy (RSB) allowed early diagnosis of IVLBCL. Discussion: The usefulness of RSB, which involves incisional skin biopsies of three or more sites that contain subcutaneous fatty tissue, such as the thighs, abdomen and upper arms, has been debated. In cases of suspected IVLBCL, RSB is less invasive than a biopsy of the internal organs.\u00a0 Conclusion: We suggest that combining RSB with bone marrow examination may facilitate the diagnosis of IVLBCL.<\/jats:p>","DOI":"10.12890\/2022_003497","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T12:21:02Z","timestamp":1658838062000},"source":"Crossref","is-referenced-by-count":3,"title":["Early Diagnosis of Intravascular Large B-Cell Lymphoma by Random Skin Biopsy"],"prefix":"10.12890","volume":"9","author":[{"given":"Kota","family":"Sakaguchi","sequence":"additional","affiliation":[{"name":"General Medicine Center, Shimane University Hospital, Shimane, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Watari","sequence":"additional","affiliation":[{"name":"General Medicine Center, Shimane University Hospital, Shimane, Japan; Department of Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2022,7,26]]},"reference":[{"key":"10.12890\/2022_003497_ref1","doi-asserted-by":"crossref","unstructured":"<li>Shimada K, Matsue K, Yamamoto K, Murase T, Ichikawa N, Okamoto M, et al. Retrospective analysis of intravascular large B-cell lymphoma treated with rituximab-containing chemotherapy as reported by the IVL study group in Japan. <em>J Clin Oncol<\/em> 2008;<strong>26<\/strong>:3189\u2013195. doi: 10.1200\/JCO.2007.15.4278.<\/li>","DOI":"10.1200\/JCO.2007.15.4278"},{"key":"10.12890\/2022_003497_ref2","doi-asserted-by":"crossref","unstructured":"<li>Matsue K, Abe Y, Kitadate A, Miura D, Narita K, Kobayashi H, et al. Sensitivity and specificity of incisional random skin biopsy for diagnosis of intravascular large B-cell lymphoma. <em>Blood<\/em> 2019;<strong>133<\/strong>:1257\u20131259. doi: 10.1182\/blood-2018-11-887570.<\/li>","DOI":"10.1182\/blood-2018-11-887570"},{"key":"10.12890\/2022_003497_ref3","doi-asserted-by":"crossref","unstructured":"<li>Fonkem E, Lok E, Robison D, Gautam S, Wong ET. The natural history of intravascular lymphomatosis. <em>Cancer Med<\/em> 2014;<strong>3<\/strong>:1010\u20131024. doi: 10.1002\/cam4.269.<\/li>","DOI":"10.1002\/cam4.269"},{"key":"10.12890\/2022_003497_ref4","doi-asserted-by":"crossref","unstructured":"<li>Fonkem E, Dayawansa S, Stroberg E, Lok E, Bricker PC, Kirmani B, et al. Neurological presentations of intravascular lymphoma (IVL): meta-analysis of 654 patients. <em>BMC Neurol<\/em> 2016;<strong>16<\/strong>:9. doi: 10.1186\/s12883-015-0509-8.<\/li>","DOI":"10.1186\/s12883-015-0509-8"},{"key":"10.12890\/2022_003497_ref5","doi-asserted-by":"crossref","unstructured":"<li>Ferreri AJ, Dognini GP, Campo E, Willemze R, Seymour JF, Bairey O, et al.; International Extranodal Lymphoma Study Group (IELSG). Variations in clinical presentation, frequency of hemophagocytosis and clinical behavior of intravascular lymphoma diagnosed in different geographical regions. <em>Haematologica<\/em> 2007;<strong>92<\/strong>:486\u2013492. doi: 10.3324\/haematol.10829.<\/li>","DOI":"10.3324\/haematol.10829"},{"key":"10.12890\/2022_003497_ref6","doi-asserted-by":"crossref","unstructured":"<li>Sitthinamsuwan P, Chinthammitr Y, Pattanaprichakul P, Sukpanichnant S. Random skin biopsy in the diagnosis of intravascular lymphoma. <em>J Cutan Pathol<\/em> 2017;<strong>44<\/strong>:729\u2013733. doi: 10.1111\/cup.12984.<\/li>","DOI":"10.1111\/cup.12984"},{"key":"10.12890\/2022_003497_ref7","doi-asserted-by":"crossref","unstructured":"<li>Sakurai T, Wakida K, Takahashi T, Ishida K, Iwata H, Nishida H. Usefulness of senile hemangioma biopsy for diagnosis of intravascular large B-cell lymphoma: a report of two cases and a literature review. <em>J Neurol Sci<\/em> 2017;<strong>373<\/strong>:52\u201354. doi: 10.1016\/j.jns.2016.12.026.<\/li>","DOI":"10.1016\/j.jns.2016.12.026"},{"key":"10.12890\/2022_003497_ref8","doi-asserted-by":"crossref","unstructured":"<li>Pongpudpunth M, Rattanakaemakorn P, Fleischer AB Jr. Usefulness of random skin biopsy as a diagnostic tool of intravascular lymphoma presenting with fever of unknown origin. <em>Am J Dermatopathol<\/em> 2015;<strong>37<\/strong>:686\u2013690. doi: 10.1097\/DAD.0000000000000321.<\/li>","DOI":"10.1097\/DAD.0000000000000321"},{"key":"10.12890\/2022_003497_ref9","doi-asserted-by":"crossref","unstructured":"<li>Enzan N, Kitadate A, Tanaka A, Matsue K. Incisional random skin biopsy, not punch biopsy, is an appropriate method for diagnosis of intravascular large B-cell lymphoma: a clinicopathological study of 25 patients. <em>Br J Dermatol<\/em> 2019;<strong>181<\/strong>:200\u2013201. doi: 10.1111\/bjd.17603.<\/li>","DOI":"10.1111\/bjd.17603"},{"key":"10.12890\/2022_003497_ref10","doi-asserted-by":"crossref","unstructured":"<li>Maekawa T, Komine M, Murata S, Fukushima N, Ohtsuki M. Random skin biopsy of patients with intravascular large B-cell lymphoma associated with thrombocytopenia and coagulation abnormalities: proposal of a modified biopsy method. <em>J Dermatol<\/em> 2015;<strong>42<\/strong>:318\u2013321. doi: 10.1111\/1346-8138.12756.<\/li>","DOI":"10.1111\/1346-8138.12756"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3497\/3182","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3497\/3183","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3497\/3183","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T09:31:17Z","timestamp":1755855077000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/3497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,26]]},"references-count":10,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.12890\/2022_003497","relation":{"has-manifestation":[{"id-type":"other","id":"1-88-3497-g3182","asserted-by":"subject"},{"id-type":"other","id":"1-88-3497-g3183","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-88","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2022,7,26]]},"article-number":"2"}}