{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T14:40:05Z","timestamp":1755787205518,"version":"3.44.0"},"reference-count":10,"publisher":"SMC Media","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Introduction: Hemolysis, elevated liver enzymes, low platelet count (HELLP) syndrome is a leading cause of maternal mortality. The emergence of Coronavirus disease 2019 (COVID-19) has led to challenges in diagnosing HELLP syndrome due to overlapping clinical and laboratory presentations. We report a case of HELLP syndrome complicated by COVID-19 infection. Case Description: An otherwise healthy pregnant 31-year-old female presented with fever, myalgia, and headache. She was found to be COVID-positive with laboratory signs of HELLP syndrome. Symptoms and laboratory findings trended toward normal post-partum confirming the diagnosis of HELLP syndrome. Discussion: A prompt diagnosis of HELLP syndrome is essential to avoid maternal and fetal complications. Clinicians should be aware of the similarities in presentation between HELLP syndrome and COVID-19 for timely diagnosis and treatment.<\/jats:p>","DOI":"10.12890\/2022_003540","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T03:33:41Z","timestamp":1662521621000},"source":"Crossref","is-referenced-by-count":2,"title":["Overlapping Presentations of HELLP Syndrome and COVID-19: A Case Report"],"prefix":"10.12890","volume":"9","author":[{"given":"Leila","family":"Tou","sequence":"additional","affiliation":[{"name":"Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Wang","sequence":"additional","affiliation":[{"name":"Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taha","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Philadelphia College of Osteopathic Medicine, NW, Suwanee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Mamone","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Florida Atlantic University, Boca Raton, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2022,9,7]]},"reference":[{"key":"10.12890\/2022_003540_ref1","doi-asserted-by":"crossref","unstructured":"<li>Haram K, Svendsen E, Abildgaard U. The HELLP syndrome: clinical issues and management. A review. <em>BMC Pregnancy Childbirth<\/em> 2009;<strong>9<\/strong>(1):8. doi:10.1186\/1471-2393-9-8<\/li>","DOI":"10.1186\/1471-2393-9-8"},{"key":"10.12890\/2022_003540_ref2","doi-asserted-by":"crossref","unstructured":"<li>Long R, Wu D, Lin X, Lv D, Wang R, Jin L, et al. COVID-19 and pregnancy: a case study. <em>Glob Chall<\/em> 2021;<strong>5<\/strong>(8):2000074. doi:10.1002\/gch2.202000074<\/li>","DOI":"10.1002\/gch2.202000074"},{"key":"10.12890\/2022_003540_ref3","doi-asserted-by":"crossref","unstructured":"<li>Coronado-Arroyo JC, Concepci\u00f3n-Zavaleta MJ, Zavaleta-Guti\u00e9rrez FE, Concepci\u00f3n-Urteaga LA. Is COVID-19 a risk factor for severe preeclampsia? Hospital experience in a developing country. <em>Eur J Obstet Gynecol Reprod Biol<\/em> 2021;<strong>256<\/strong>:502\u2013503. doi:10.1016\/j.ejogrb.2020.09.020<\/li>","DOI":"10.1016\/j.ejogrb.2020.09.020"},{"key":"10.12890\/2022_003540_ref4","doi-asserted-by":"crossref","unstructured":"<li>Futterman I, Toaff M, Navi L, Clare CA. COVID-19 and HELLP: overlapping clinical pictures in two gravid patients. <em>AJP Rep<\/em> 2020;<strong>10<\/strong>(02):e179\u2013e182. doi:10.1055\/s-0040-1712978<\/li>","DOI":"10.1055\/s-0040-1712978"},{"key":"10.12890\/2022_003540_ref5","doi-asserted-by":"crossref","unstructured":"<li>Arslan E. COVID-19: a cause of HELLP syndrome? A case report. <em>IJWH<\/em> 2022;<strong>14<\/strong>:617\u2013623. doi:10.2147\/IJWH.S362877<\/li>","DOI":"10.2147\/IJWH.S362877"},{"key":"10.12890\/2022_003540_ref6","doi-asserted-by":"crossref","unstructured":"<li>Shanes ED, Mithal LB, Otero S, Azad HA, Miller ES, Goldstein JA. Placental pathology in COVID-19. <em>Am J Clin Pathol<\/em> 2020;<strong>154<\/strong>(1):23\u201332. doi:10.1093\/ajcp\/aqaa089<\/li>","DOI":"10.1093\/ajcp\/aqaa089"},{"key":"10.12890\/2022_003540_ref7","doi-asserted-by":"crossref","unstructured":"<li>Sharps MC, Hayes DJL, Lee S, Zou Z, Brady CA, Almoghrabi Y, et al. A structured review of placental morphology and histopathological lesions associated with SARS-CoV-2 infection. <em>Placenta<\/em> 2020;<strong>101<\/strong>:13\u201329. doi:10.1016\/j.placenta.2020.08.018<\/li>","DOI":"10.1016\/j.placenta.2020.08.018"},{"key":"10.12890\/2022_003540_ref8","doi-asserted-by":"crossref","unstructured":"<li>Ronnje L, L\u00e4nsberg JK, Vikhareva O, Hansson SR, Herbst A, Zaigham M. Complicated COVID-19 in pregnancy: a case report with severe liver and coagulation dysfunction promptly improved by delivery. <em>BMC Pregnancy Childbirth<\/em> 2020;<strong>20<\/strong>(1):511. doi:10.1186\/s12884-020-03172-8<\/li>","DOI":"10.1186\/s12884-020-03172-8"},{"key":"10.12890\/2022_003540_ref9","unstructured":"<li>Popovici D, Crauciuc E, Tiperciuc R-A, Buznea G-A, Akad M, Hurjui L, et al. HELLP syndrome complicated with ascites during third trimester of pregnancy \u2013 therapeutic management. <em>Maedica (Bucur)<\/em> 2018;<strong>13<\/strong>(4):331\u2013335. doi:10.26574\/maedica.2018.13.4.331<\/li>"},{"key":"10.12890\/2022_003540_ref10","doi-asserted-by":"crossref","unstructured":"<li>Figueras F, Llurba E, Martinez-Portilla R, Mora J, Crispi F, Gratacos E. COVID-19 causing HELLP-like syndrome in pregnancy and role of angiogenic factors for differential diagnosis. <em>medRxiv<\/em> 2020. 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