{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T23:54:51Z","timestamp":1778111691164,"version":"3.51.4"},"reference-count":11,"publisher":"SMC Media","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Sirolimus is an inhibitor of the mammalian target of rapamycin, which is used in kidney transplant immunosuppression. The clinical spectrum of cutaneous adverse events associated with sirolimus use varies, with maculopapular rash being an uncommon side effect very rarely reported in the literature. We present the case of a 78-year-old male renal transplant recipient who developed a diffuse maculopapular pruritic rash after starting sirolimus. This case report demonstrates that maculopapular rash is an uncommon sirolimus-related side effect that must be identified promptly so the medication can be discontinued and rash progression prevented.<\/jats:p>","DOI":"10.12890\/2022_003565","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T03:20:15Z","timestamp":1663816815000},"source":"Crossref","is-referenced-by-count":2,"title":["Sirolimus-Induced Rash in a Kidney Transplant Patient"],"prefix":"10.12890","volume":"9","author":[{"given":"Zachary","family":"Bruss","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanza","family":"Farook","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Shifa International Hospital, Islamabad, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sana","family":"Shah","sequence":"additional","affiliation":[{"name":"Aga Khan University, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abu","family":"Baker Sheikh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hospital Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2022,9,22]]},"reference":[{"key":"10.12890\/2022_003565_ref1","doi-asserted-by":"crossref","unstructured":"<li>Kunzle N, Venetz JP, Pascual M, Panizzon RG, Laffitte E. Sirolimus-induced acneiform eruption. <em>Dermatology<\/em> 2005;<strong>211<\/strong>(4):366\u2013369. doi:10.1159\/000088511<\/li>","DOI":"10.1159\/000088511"},{"key":"10.12890\/2022_003565_ref2","doi-asserted-by":"crossref","unstructured":"<li>Kaplan B, Qazi Y, Wellen JR. Strategies for the management of adverse events associated with mTOR inhibitors. <em>Transplant Rev (Orlando)<\/em> 2014;<strong>28<\/strong>(3):126\u2013133. doi:10.1016\/j.trre.2014.03.002<\/li>","DOI":"10.1016\/j.trre.2014.03.002"},{"key":"10.12890\/2022_003565_ref3","doi-asserted-by":"crossref","unstructured":"<li>Kniepeiss D, Iberer F, Grasser B, Schaffellner S, Tscheliessnigg KH. Sirolimus and mycophenolate mofetil after liver transplantation. <em>Transpl Int<\/em> 2003;<strong>16<\/strong>(7):504\u2013509. doi:10.1007\/s00147-003-0579-1<\/li>","DOI":"10.1111\/j.1432-2277.2003.tb00339.x"},{"key":"10.12890\/2022_003565_ref4","doi-asserted-by":"crossref","unstructured":"<li>Shitrit D, Rahamimov R, Gidon S, Bakal I, Bargil-Shitrit A, Milton S, et al. Use of sirolimus and low-dose calcineurin inhibitor in lung transplant recipients with renal impairment: results of a controlled pilot study. <em>Kidney Int<\/em> 2005;<strong>67<\/strong>(4):1471\u20131475. doi:10.1111\/j.1523-1755.2005.00224.x<\/li>","DOI":"10.1111\/j.1523-1755.2005.00224.x"},{"key":"10.12890\/2022_003565_ref5","doi-asserted-by":"crossref","unstructured":"<li>Mah\u00e9 E, Morelon E, Lechaton S, Sang KH, Mansouri R, Ducasse MF, et al. Cutaneous adverse events in renal transplant recipients receiving sirolimus-based therapy. <em>Transplantation<\/em> 2005;<strong>79<\/strong>(4):476\u2013482. doi:10.1097\/01.tp.0000151630.25127.3a<\/li>","DOI":"10.1097\/01.TP.0000151630.25127.3A"},{"key":"10.12890\/2022_003565_ref6","doi-asserted-by":"crossref","unstructured":"<li>Vasquez EM. Sirolimus: a new agent for prevention of renal allograft rejection. <em>Am J Health Syst Pharm<\/em> 2000;<strong>57<\/strong>(5):437\u2013451. doi:10.1093\/ajhp\/57.5.437<\/li>","DOI":"10.1093\/ajhp\/57.5.437"},{"key":"10.12890\/2022_003565_ref7","doi-asserted-by":"crossref","unstructured":"<li>Cheng JY, Cohen PR. Sirolimus-associated pruritus: case report and review. Cureus 2017 Jun 27;<strong>9<\/strong>(6):e1398. doi:10.7759\/cureus.1398<\/li>","DOI":"10.7759\/cureus.1398"},{"key":"10.12890\/2022_003565_ref8","doi-asserted-by":"crossref","unstructured":"<li>Tracey C, Hawley C, Griffin AD, Strutton G, Lynch S. Generalized, pruritic, ulcerating maculopapular rash necessitating cessation of sirolimus in a liver transplantation patient. <em>Liver Transpl<\/em> 2005;<strong>11<\/strong>(8):987\u2013989. doi:10.1002\/lt.20499<\/li>","DOI":"10.1002\/lt.20499"},{"key":"10.12890\/2022_003565_ref9","doi-asserted-by":"crossref","unstructured":"<li>Gomez-Fernandez C, Garden BC, Wu S, Feldman DR, Lacouture ME. The risk of skin rash and stomatitis with the mammalian target of rapamycin inhibitor temsirolimus: a systematic review of the literature and meta-analysis. <em>Eur J Cancer<\/em> 2012;<strong>48<\/strong>(3):340\u2013346. doi:10.1016\/j.ejca.2011.11.028<\/li>","DOI":"10.1016\/j.ejca.2011.11.028"},{"key":"10.12890\/2022_003565_ref10","doi-asserted-by":"crossref","unstructured":"<li>Lynch TJ Jr, Kim ES, Eaby B, Garey J, West DP, Lacouture ME. Epidermal growth factor receptor inhibitor-associated cutaneous toxicities: an evolving paradigm in clinical management. <em>Oncologist<\/em> 2007;<strong>12<\/strong>(5):610\u2013621. doi:10.1634\/theoncologist.12-5-610<\/li>","DOI":"10.1634\/theoncologist.12-5-610"},{"key":"10.12890\/2022_003565_ref11","doi-asserted-by":"crossref","unstructured":"<li>Kim S, Wong P, Coulombe PA. A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth. <em>Nature<\/em> 2006;<strong>441<\/strong>(7091):362\u2013365. doi:10.1038\/nature04659<\/li>","DOI":"10.1038\/nature04659"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3565\/3237","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3565\/3238","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3565\/3238","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T14:04:50Z","timestamp":1755785090000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/3565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,22]]},"references-count":11,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.12890\/2022_003565","relation":{"has-manifestation":[{"id-type":"other","id":"1-90-3565-g3237","asserted-by":"subject"},{"id-type":"other","id":"1-90-3565-g3238","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-90","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"value":"2284-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,22]]},"article-number":"15"}}