{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:52:04Z","timestamp":1787021524575,"version":"build-2736575974"},"reference-count":6,"publisher":"SMC Media","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>A 67-year-old man with a history of IgM deficiency and pulmonary fibrosis and bronchiectasis was admitted for management of worsening symptoms. Investigations revealed exudative pleural effusion with rapidly progressive bronchiectasis. Although a potential trigger of bronchiectasis and pulmonary fibrosis was not identified despite extensive work-up by several physicians in the past, a bedside observation of yellow dystrophic nails on all extremities revealed the diagnosis. This case report helps to remind clinicians of a rare medical disorder of still uncertain aetiology and no available cure. This case is consistent with a few previous case reports that suggest a potential association with selective immunoglobulin deficiency.<\/jats:p>","DOI":"10.12890\/2022_003577","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T03:31:58Z","timestamp":1664249518000},"source":"Crossref","is-referenced-by-count":1,"title":["Rapidly Progressive Bronchiectasis and Pulmonary Fibrosis in Yellow Nail Syndrome with Possible Association with Selective IgM Deficiency"],"prefix":"10.12890","volume":"9","author":[{"given":"Mohammad","family":"Abu-Abaa","sequence":"additional","affiliation":[{"name":"Internal Medicine, Capital Health Regional Medical Center, Trenton, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Hassan","sequence":"additional","affiliation":[{"name":"Internal Medicine, Capital Health Regional Medical Center, Trenton, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bashar","family":"Oudah","sequence":"additional","affiliation":[{"name":"Eisenhower Health, Rancho Mirage, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor","family":"Al-Ameri","sequence":"additional","affiliation":[{"name":"Internal Medicine, Capital Health Regional Medical Center, Trenton, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10397","published-online":{"date-parts":[[2022,9,27]]},"reference":[{"key":"10.12890\/2022_003577_ref1","doi-asserted-by":"crossref","unstructured":"<li>Gupta S, Samra D, Yel L, Agrawal S. T and B cell deficiency associated with yellow nail syndrome. <em>Scand J Immunol<\/em> 2012 Mar;<strong>75<\/strong>(3):329\u2013335. doi: 10.1111\/j.1365-3083.2011.02653.x<\/li>","DOI":"10.1111\/j.1365-3083.2011.02653.x"},{"key":"10.12890\/2022_003577_ref2","doi-asserted-by":"crossref","unstructured":"<li>Douri T. Yellow nails syndrome in two siblings. <em>Dermatol Online J<\/em> 2008 Sep 15;<strong>14<\/strong>(9):7. PMID: 19061589.<\/li>","DOI":"10.5070\/D33X40Q9D0"},{"key":"10.12890\/2022_003577_ref3","doi-asserted-by":"crossref","unstructured":"<li>Maldonado F, Tazelaar HD, Wang C-W, Ryu JH. Yellow nail syndrome: analysis of 41 consecutive patients. <em>Chest<\/em> 2008;<strong>134<\/strong>:375\u2013381.<\/li>","DOI":"10.1378\/chest.08-0137"},{"key":"10.12890\/2022_003577_ref4","doi-asserted-by":"crossref","unstructured":"<li>Bokszezannin A, Levinson AL. Coexistent yellow nail syndrome and selective antibody deficiency.<em>Ann Allergy Asthma Immunol<\/em> 2003;<strong>91<\/strong>:496\u2013500.<\/li>","DOI":"10.1016\/S1081-1206(10)61521-9"},{"key":"10.12890\/2022_003577_ref5","doi-asserted-by":"crossref","unstructured":"<li>Vignes S, Baran R. Yellow nail syndrome: a review. <em>Orphanet J Rare Dis<\/em> 2017;<strong>12<\/strong>(1):42. https:\/\/doi.org\/10.1186\/s13023-017-0594-4<\/li>","DOI":"10.1186\/s13023-017-0594-4"},{"key":"10.12890\/2022_003577_ref6","doi-asserted-by":"crossref","unstructured":"<li>Woodfield G, Nisbet M, Jacob J, Mok W, Loebinger MR, Hansell DM, et al. 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