{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:13:03Z","timestamp":1769559183873,"version":"3.49.0"},"reference-count":16,"publisher":"SMC Media","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Introduction: Amyloidosis is a rare illness characterized by the deposition in organs of amyloid, which can be detected by histological staining. Amyloidosis restricted to the lower respiratory tract is unusual. Results: We reported the case of a 68-year-old woman with no history of chronic disease who presented with dyspnoea on exertion, cough and fatigue. The physical examination was unremarkable. A CT scan showed a cystic mass with a thickened wall in the apical segment of the left lower lobe. A biopsy of the mass was performed, and histological and immunohistochemical study confirmed the diagnosis of AL amyloidosis. The patient\u2019s clinical and radiological symptoms spontaneously improved without treatment after 3 years. Conclusion: Amyloid-related cystic lung disease is a rare presentation of amyloidosis in the thorax. More case reports are required to determine if such masses can resolve without treatment and whether amyloid-associated cystic lung disease actually exists. \u00a0<\/jats:p>","DOI":"10.12890\/2022_003586","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T03:36:35Z","timestamp":1669865795000},"source":"Crossref","is-referenced-by-count":1,"title":["Spontaneous Resolution of a Pulmonary Cystic Amyloidosis Mass"],"prefix":"10.12890","volume":"9","author":[{"given":"Nouha","family":"Guediri","sequence":"first","affiliation":[{"name":"Pulmonology Department, Military Hospital of Tunis, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Islam","family":"Meijri","sequence":"first","affiliation":[{"name":"Pulmonology Department, Military Hospital of Tunis, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nouha","family":"Boubaker","sequence":"first","affiliation":[{"name":"Pulmonology Department, Military Hospital of Tunis, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samira","family":"Mhamdi","sequence":"first","affiliation":[{"name":"Pulmonology Department, Military Hospital of Tunis, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selsabil","family":"Daboussi","sequence":"first","affiliation":[{"name":"Pulmonology Department, Military Hospital of Tunis, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiraz","family":"Aichaouia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houssem","family":"Messaoudi","sequence":"first","affiliation":[{"name":"Thoracic Surgery Department, Military Hospital of Tunis, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida","family":"Ayadi","sequence":"first","affiliation":[{"name":"Anatomo-Pathology Department, Abdurrahman Mami Hospital, Ariana, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zied","family":"Moatemri","sequence":"first","affiliation":[{"name":"Pulmonology Department, Military Hospital of Tunis, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2022,11,29]]},"reference":[{"key":"10.12890\/2022_003586_ref1","doi-asserted-by":"crossref","unstructured":"<li>Baker KR, Rice L. The amyloidoses: clinical features, diagnosis and treatment. <em>Methodist DeBakey Cardiovasc J<\/em> 2012;<strong>8<\/strong>(3):3\u20137. <\/li>","DOI":"10.14797\/mdcj-8-3-3"},{"key":"10.12890\/2022_003586_ref2","doi-asserted-by":"crossref","unstructured":"<li>Sipe JD, Benson MD, Buxbaum JN, Ikeda S-I, Merlini G, Saraiva MJM, et al. Nomenclature 2014: Amyloid fibril proteins and clinical classification of the amyloidosis. <em>Amyloid<\/em> 2014;<strong>21<\/strong>(4):221\u2013224. <\/li>","DOI":"10.3109\/13506129.2014.964858"},{"key":"10.12890\/2022_003586_ref3","doi-asserted-by":"crossref","unstructured":"<li>Yakupova EI, Bobyleva LG, Vikhlyantsev IM, Bobylev AG. Congo Red and amyloids: history and relationship.<em> Biosci Rep<\/em> 2019;<strong>39<\/strong>(1):BSR20181415.<\/li>","DOI":"10.1042\/BSR20181415"},{"key":"10.12890\/2022_003586_ref4","doi-asserted-by":"crossref","unstructured":"<li>Mohammadien HA, Morsi SN, Al Shahat MA. Systemic AL amyloidosis presenting with diffuse alveolar septal involvement and respiratory failure: a case report and review of the literature. <em>Egypt J Bronchol<\/em> 2021;<strong>15<\/strong>(1):1\u20139. <\/li>","DOI":"10.1186\/s43168-021-00070-1"},{"key":"10.12890\/2022_003586_ref5","doi-asserted-by":"crossref","unstructured":"<li>Cordier JF, Loire R, Brune J. Amyloidosis of the lower respiratory tract: clinical and pathologic features in a series of 21 patients. <em>Chest<\/em> 1986;<strong>90<\/strong>(6):827\u2013831.<\/li>","DOI":"10.1378\/chest.90.6.827"},{"key":"10.12890\/2022_003586_ref6","doi-asserted-by":"crossref","unstructured":"<li>Marchiori E, Souza Jr. AS, Ferreira A, Azevedo KC, Fialho SM, Crespo SJV. Amiloidose pulmonar: aspectos na tomografia computadorizada. <em>Radiol Bras<\/em> 2003;<strong>36<\/strong>:89\u201394.<\/li>","DOI":"10.1590\/S0100-39842003000200007"},{"key":"10.12890\/2022_003586_ref7","doi-asserted-by":"crossref","unstructured":"<li>Urban BA, Fishman EK, Goldman SM, Scott WW, Jones B, Humphrey RL, et al. CT evaluation of amyloidosis: spectrum of disease. <em>Radiographics<\/em> 1993;<strong>13<\/strong>(6):1295\u20131308. <\/li>","DOI":"10.1148\/radiographics.13.6.8290725"},{"key":"10.12890\/2022_003586_ref8","unstructured":"<li>Hui AN, Koss MN, Hochholzer L, Wehunt WD. Amyloidosis presenting in the lower respiratory tract. Clinicopathologic, radiologic, immunohistochemical, and histochemical studies on 48 cases. <em>Arch Pathol Lab Med<\/em> 1986;<strong>110<\/strong>:212\u2013218.<\/li>"},{"key":"10.12890\/2022_003586_ref9","doi-asserted-by":"crossref","unstructured":"<li>M\u00f6llers MJ, van Schaik JP, van der Putte SC. Pulmonary amyloidoma. Histologic proof yielded by transthoracic coaxial fine needle biopsy. <em>Chest<\/em> 1992;<strong>102<\/strong>:1597\u20131598.<\/li>","DOI":"10.1378\/chest.102.5.1597"},{"key":"10.12890\/2022_003586_ref10","unstructured":"<li>Rubinow A, Celli BR, Cohen AS, Rigden BG, Brody JS. Localized amyloidosis of the lower respiratory tract. <em>Am Rev Respir Dis<\/em> 1978;<strong>118<\/strong>:603\u2013611.<\/li>"},{"key":"10.12890\/2022_003586_ref11","doi-asserted-by":"crossref","unstructured":"<li>Ohdama S, Akagawa S, Matsubara O, Yoshizawa Y. Primary diffuse alveolar septal amyloidosis with multiple cysts and calcification. <em>Eur Respir J<\/em> 1996;<strong>9<\/strong>(7):1569\u20131571. <\/li>","DOI":"10.1183\/13993003\/erj.9.7.1569"},{"key":"10.12890\/2022_003586_ref12","doi-asserted-by":"crossref","unstructured":"<li>Lim JK, Lacy MQ, Kurtin PJ, Kyle RA, Gertz MA. Pulmonary marginal zone lymphoma of MALT type as a cause of localised pulmonary amyloidosis.<em>J Clin Pathol<\/em> 2001;<strong>54<\/strong>(8):642\u2013646. <\/li>","DOI":"10.1136\/jcp.54.8.642"},{"key":"10.12890\/2022_003586_ref13","doi-asserted-by":"crossref","unstructured":"<li>Azzopardi JG, Lehner T. Systemic amyloidosis and malignant disease. <em>J Clin Pathol<\/em> 1966;<strong>19<\/strong>(6):539\u2013548.<\/li>","DOI":"10.1136\/jcp.19.6.539"},{"key":"10.12890\/2022_003586_ref14","doi-asserted-by":"crossref","unstructured":"<li>Glass LN, Sumon M, Goulart H, Ahari J. Disappearing nodules: spontaneously regressing pulmonary amyloidosis. <em>BMJ Case Rep<\/em> 2019;<strong>12<\/strong>(5):e229718. <\/li>","DOI":"10.1136\/bcr-2019-229718"},{"key":"10.12890\/2022_003586_ref15","doi-asserted-by":"crossref","unstructured":"<li>Fukatsu H, Miyoshi H, Ishiki K. Spontaneous resolution of multiple nodular pulmonary AA amyloidosis. <em>Intern Med<\/em> 2010;<strong>49<\/strong>(21):2303\u20132307. <\/li>","DOI":"10.2169\/internalmedicine.49.3894"},{"key":"10.12890\/2022_003586_ref16","unstructured":"<li>Doshi A, Rodrigues M, Deshpande R, Udwadia Z. Spontaneous resolution of diffuse alveolar septal amyloidosis. <em>Indian J Chest Dis Allied Sci<\/em> 2001;<strong>43<\/strong>(3):177\u2013179. <\/li>"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3586\/3302","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3586\/3303","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3586\/3303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T13:48:58Z","timestamp":1755784138000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/3586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,29]]},"references-count":16,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.12890\/2022_003586","relation":{"has-manifestation":[{"id-type":"other","id":"1-92-3586-g3302","asserted-by":"subject"},{"id-type":"other","id":"1-92-3586-g3303","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-92","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"value":"2284-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,29]]}}}