{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T02:10:55Z","timestamp":1755828655646,"version":"3.44.0"},"reference-count":5,"publisher":"SMC Media","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>A 28-year-old female patient was hospitalized for mild\u2013moderate hypokalaemia which was persistent despite discontinuation of beta-2 agonist bronchodilator treatment. Her past medical history was relevant for two episodes of severe hypokalaemia after active inhaled beta-2 agonist treatment for asthma crisis. Investigations revealed increased potassium in spot urine with a transtubular potassium gradient &lt;4. A 24-hour urine analysis showed hypophosphaturia, hypocalciuria, hypomagnesuria and normal urine prostaglandins in favour of Gitelman syndrome. Oral potassium supplementation was started and genetic studies were recommended.<\/jats:p>","DOI":"10.12890\/2022_003605","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T04:47:00Z","timestamp":1666327620000},"source":"Crossref","is-referenced-by-count":0,"title":["Recurrent Episodes of Hypokalaemia during Treatment with Inhaled Beta-2 Agonist Revealing Gitelman Syndrome, an Uncommon Clinical Entity"],"prefix":"10.12890","volume":"9","author":[{"given":"Nery","family":"Sabl\u00f3n-Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Servicio de Nefrolog\u00eda, Hospital Universitario de Gran Canaria Dr. Negrin, Las Palmas de Gran Canaria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanet","family":"Parodis-Lopez","sequence":"first","affiliation":[{"name":"Servicio de Nefrolog\u00eda, Hospital Universitario de Gran Canaria Dr. Negrin, Las Palmas de Gran Canaria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Belen","family":"Alonso-Ortiz","sequence":"first","affiliation":[{"name":"Servicio de Medicina Interna, Hospital Universitario de Gran Canaria Dr. Negrin, Las Palmas de Gran Canaria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ang\u00e9lica","family":"Laurin","sequence":"first","affiliation":[{"name":"Centro de Atenci\u00f3n Primaria Barrio Atl\u00e1ntico, Las Palmas de Gran Canaria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Andres","sequence":"first","affiliation":[{"name":"Service de M\u00e9decine Interne, Diab\u00e8te et Maladies M\u00e9taboliques. H\u00f4pitaux Universitaires de Strasbourg, Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noel","family":"Lorenzo Villalba","sequence":"first","affiliation":[{"name":"Service de M\u00e9decine Interne, Diab\u00e8te et Maladies M\u00e9taboliques. H\u00f4pitaux Universitaires de Strasbourg, Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2022,10,20]]},"reference":[{"key":"10.12890\/2022_003605_ref1","doi-asserted-by":"crossref","unstructured":"<li> Knoers NV, Levtchenko EN. Gitelman syndrome. <em>Orphanet J Rare Dis<\/em> 2008;<strong>3<\/strong>:22.<\/li>","DOI":"10.1186\/1750-1172-3-22"},{"key":"10.12890\/2022_003605_ref2","doi-asserted-by":"crossref","unstructured":"<li> Grillone T, Menniti M, Bombardiere F, Vismara MF, Belviso S, Fabiani F, et al. New SLC12A3 disease causative mutation of Gitelman's syndrome.<em>World J Nephrol<\/em> 2016 Nov 6;<strong>5<\/strong>(6):551\u2013555. doi: 10.5527\/wjn.v5.i6.551<\/li>","DOI":"10.5527\/wjn.v5.i6.551"},{"key":"10.12890\/2022_003605_ref3","unstructured":"<li> Molina A, Mon C, Oliet A, Ortiz M. Variabilidad cl\u00ednica del s\u00edndrome de Gitelman. <em>Nefrologia<\/em> 2006;<strong>26<\/strong>:504\u2013506. <\/li>"},{"key":"10.12890\/2022_003605_ref4","doi-asserted-by":"crossref","unstructured":"<li> Yeh FC, Chiang WF, Wang CC, Lin SH. Thyrotoxic periodic paralysis triggered by B2-adrenergic bronchodilators. <em>CJEM<\/em> 2014 May;<strong>16<\/strong>(3):247\u2013251.<\/li>","DOI":"10.2310\/8000.2013.130867"},{"key":"10.12890\/2022_003605_ref5","doi-asserted-by":"crossref","unstructured":"<li> Al Shibli A, Narchi H. Bartter and Gitelman syndromes: spectrum of clinical manifestations caused by different mutations. <em>World J Methodol<\/em> 2015;<strong>5<\/strong>:55\u201361.<\/li>","DOI":"10.5662\/wjm.v5.i2.55"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3605\/3264","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3605\/3265","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3605\/3265","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T13:55:34Z","timestamp":1755784534000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/3605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,20]]},"references-count":5,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.12890\/2022_003605","relation":{"has-manifestation":[{"id-type":"other","id":"1-91-3605-g3264","asserted-by":"subject"},{"id-type":"other","id":"1-91-3605-g3265","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-91","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2022,10,20]]}}}