{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T02:10:53Z","timestamp":1755828653860,"version":"3.44.0"},"reference-count":6,"publisher":"SMC Media","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Ofatumumab is a monoclonal antibody used in the treatment of recurrent and progressive chronic lymphocytic leukaemia (CLL) and was recently approved for the treatment of multiple sclerosis. We describe the case of a 68-year-old man who presented with complaints of irregular pulse readings while undergoing ofatumumab treatment for recurrent CLL. Electrocardiograms (ECGs) demonstrated premature ventricular contractions (PVCs) which eventually caused cardiomyopathy and failed to resolve despite ablative therapy. Ofatumumab-induced PVCs are confirmed in this case by the existence of documented PVCs on ECGs and the disappearance of these PVCs after the completion of ofatumumab treatment. To the best of our knowledge, there have been no previously reported cases of PVCs associated with ofatumumab in the literature.\u00a0<\/jats:p>","DOI":"10.12890\/2022_003625","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T08:41:27Z","timestamp":1668415287000},"source":"Crossref","is-referenced-by-count":0,"title":["Premature Ventricular Contractions and Cardiomyopathy while on Ofatumumab for Treatment of Chronic Lymphocytic Leukaemia"],"prefix":"10.12890","volume":"9","author":[{"given":"Oladipo","family":"Odeyinka","sequence":"first","affiliation":[{"name":"Rush University Medical Center, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell","family":"Collins","sequence":"first","affiliation":[{"name":"Rush University Medical Center, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Sunnaa","sequence":"first","affiliation":[{"name":"Rush University Medical Center, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parameswaran","family":"Venugopal","sequence":"first","affiliation":[{"name":"Rush University Medical Center, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tochukwu","family":"Okwuosa","sequence":"first","affiliation":[{"name":"Rush University Medical Center, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2022,11,14]]},"reference":[{"key":"10.12890\/2022_003625_ref1","doi-asserted-by":"crossref","unstructured":"<li>Robak T, Warzocha K, Govind Babu K, Kulyaba Y, Kuliczkowski K, Abdulkadyrov K, et al. Ofatumumab plus fludarabine and cyclophosphamide in relapsed chronic lymphocytic leukemia: results from the COMPLEMENT 2 trial. <em>Leuk Lymphoma<\/em> 2017 May 4;<strong>58<\/strong>(5):1084\u20131093. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/27731748\/<\/li>","DOI":"10.1080\/10428194.2016.1233536"},{"key":"10.12890\/2022_003625_ref2","doi-asserted-by":"crossref","unstructured":"<li>Buza V, Rajagopalan B, Curtis AB. Cancer treatment\u2013induced arrhythmias. <em>Circ Arrhythm Electrophysiol<\/em> 2017 Aug 1;<strong>10<\/strong>(8):e005443. Available from: https:\/\/www.ahajournals.org\/doi\/abs\/10.1161\/CIRCEP.117.005443<\/li>","DOI":"10.1161\/CIRCEP.117.005443"},{"key":"10.12890\/2022_003625_ref3","doi-asserted-by":"crossref","unstructured":"<li>Jewell RC, Laubscher K, Lewis E, Fang L, Gafoor Z, Carey J, et al. Assessment of the effect of ofatumumab on cardiac repolarization. <em>J Clin Pharmacol<\/em> 2015;<strong>55<\/strong>(1):114\u2013121. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/25103870\/<\/li>","DOI":"10.1002\/jcph.376"},{"key":"10.12890\/2022_003625_ref4","unstructured":"<li>Takahashi J, Kawashima R, Abe Y, Fukuda H, Kubota K, Yamada K, et al. [Ventricular premature contraction observed after anti-cancer chemotherapy with ifosfamide.]<em>Gan To Kagaku Ryoho<\/em> 1994 Aug;<strong>21<\/strong>(10):1681\u20131684. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/7520222\/<\/li>"},{"key":"10.12890\/2022_003625_ref5","unstructured":"<li>Poterucha JT, Westberg M, Nerheim P, Lovell JP. Rituximab-induced polymorphic ventricular tachycardia. <em>Tex Heart Inst J<\/em> 2010;<strong>37<\/strong>(2):218. Available from: \/pmc\/articles\/PMC2851419\/<\/li>"},{"key":"10.12890\/2022_003625_ref6","unstructured":"<li>Novartis. FDA approves Novartis Kesimpta\u00ae (ofatumumab), the first and only self-administered, targeted B-cell therapy for patients with relapsing multiple sclerosis. Available from: https:\/\/novartis.gcs-web.com\/FDA-approves-Novartis-Kesimpta-ofatumumab-the-first-and-only-self-administered-targeted-B-cell-therapy-for-patients-with-relapsing-multiple-sclerosis (accessed 6 Sept 2022). <\/li>"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3625\/3290","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3625\/3291","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3625\/3291","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T13:49:10Z","timestamp":1755784150000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/3625"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,14]]},"references-count":6,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.12890\/2022_003625","relation":{"has-manifestation":[{"id-type":"other","id":"1-92-3625-g3290","asserted-by":"subject"},{"id-type":"other","id":"1-92-3625-g3291","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-92","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2022,11,14]]}}}