{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T14:10:26Z","timestamp":1755785426151,"version":"3.44.0"},"reference-count":13,"publisher":"SMC Media","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>ntroduction: Non-episodic angioedema associated with eosinophilia (NEAE) has been reported primarily in young East Asian women and is characterized by a single episode of persistent limb oedema, peripheral eosinophilia, and transient joint pain. Although there are reports of eosinophilia disease after coronavirus disease 2019 (COVID-19), the occurrence of NEAE has not been previously reported. Case description: A 29-year-old Japanese woman, with a history of allergic rhinitis and atopic dermatitis, sought a medical consultation for persisting oedema of the extremities, which developed about 2 weeks after she contracted COVID-19. Physical examination revealed symmetrical non-pitting oedema with peripheral predominance. Laboratory examination revealed a blood eosinophil count of 7536\/\u00b5l. The patient was diagnosed with NEAE and a 7-day course of prednisolone (15 mg\/day) was initiated, with rapid improvement in the oedema and no recurrence on follow-up. Discussion: The exact aetiology of NEAE is unknown, but it may develop after infection or drug exposure. Eosinophilic disease after COVID-19 infection has been reported and, therefore, eosinophilic angioedema should be considered in the differential diagnosis of non-pitting oedema of the extremities after a COVID-19 infection. Early diagnosis of NEAE is important as rapid improvement can be achieved with low-dose steroid treatment.\u00a0 Conclusion: NEAE can develop after COVID-19 and should be considered in the differential diagnosis of non-pitting oedema of the extremities.\u00a0<\/jats:p>","DOI":"10.12890\/2022_003671","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T09:30:21Z","timestamp":1672306221000},"source":"Crossref","is-referenced-by-count":2,"title":["Non-Episodic Angioedema Associated with Eosinophilia after COVID-19"],"prefix":"10.12890","volume":"9","author":[{"given":"Taku","family":"Harada","sequence":"first","affiliation":[{"name":"Department of General Medicine, Nerima Hikarigaoka Hospital, Tokyo, Japan; Department of Diagnostic and Generalist Medicine, Dokkyo Medical University Hospital, Tochigi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintaro","family":"Kosaka","sequence":"first","affiliation":[{"name":"Department of General Medicine, Nerima Hikarigaoka Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mori","family":"Nakai","sequence":"first","affiliation":[{"name":"Department of General Medicine, Nerima Hikarigaoka Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"key":"10.12890\/2022_003671_ref1","doi-asserted-by":"crossref","unstructured":"<li>Chikama R, Hosokawa M, Miyazawa T, Miura R, Suzuki T, Tagami H. 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