{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:01:03Z","timestamp":1777334463199,"version":"3.51.4"},"reference-count":9,"publisher":"SMC Media","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>We report the case of a 31-year-old woman with a history suggestive of obstetric antiphospholipid syndrome (APS) with recurrent miscarriages, preterm labour and intrauterine fetal death. During her last pregnancy, she was referred to the Rheumatology Clinic at King Fahad Military Medical Complex, Dhahran, Saudi Arabia. Serology for connective tissue diseases and APS was negative on multiple occasions. During previous pregnancies, her obstetrician had initiated several trials of baby aspirin with and without prophylactic heparin, without success. We diagnosed her with seronegative obstetric APS (SN-APS). A specific regimen, consisting of combination therapy with baby aspirin, low-molecular-weight heparin, hydroxychloroquine (&lt;5 mg\/kg\/day) and low-dose prednisolone, was attempted. She delivered a healthy baby even though it was born preterm at 30 weeks of gestation because of abruptio placentae. Obstetric SN-APS is rare and should be considered and, if the history is highly suggestive, treated similarly to seropositive obstetric APS to reduce mortality.<\/jats:p>","DOI":"10.12890\/2022_003686","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T05:54:21Z","timestamp":1670219661000},"source":"Crossref","is-referenced-by-count":4,"title":["Seronegative Obstetric Antiphospholipid Syndrome Finally Treated Successfully"],"prefix":"10.12890","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5226-3254","authenticated-orcid":false,"given":"Khawla K","family":"Alghanim","sequence":"first","affiliation":[{"name":"Rheumatology Unit, Department of Internal Medicine, King Fahad Military Medical Complex, Dhahran, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hezab A","family":"Alrayes","sequence":"first","affiliation":[{"name":"Rheumatology Unit, Department of Internal Medicine, King Fahad Military Medical Complex, Dhahran, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rayan M","family":"Aljurbua","sequence":"first","affiliation":[{"name":"Rheumatology Unit, Department of Internal Medicine, King Fahad Military Medical Complex, Dhahran, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2022,12,5]]},"reference":[{"key":"10.12890\/2022_003686_ref1","doi-asserted-by":"crossref","unstructured":"<li>Garcia D, Erkan D. 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Quinacrine added to ongoing therapeutic regimens attenuates anticardiolipin antibody production in SLE. <em>Lupus<\/em> 2003;<strong>12<\/strong>:297. doi: https:\/\/doi.org\/10.1191\/0961203303lu319oa<\/li>","DOI":"10.1191\/0961203303lu319oa"},{"key":"10.12890\/2022_003686_ref9","unstructured":"<\/ol>"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3686\/3308","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3686\/3309","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3686\/3309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T13:37:54Z","timestamp":1755783474000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/3686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,5]]},"references-count":9,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.12890\/2022_003686","relation":{"has-manifestation":[{"id-type":"other","id":"1-93-3686-g3308","asserted-by":"subject"},{"id-type":"other","id":"1-93-3686-g3309","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-93","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"value":"2284-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,5]]}}}