{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T16:38:31Z","timestamp":1784565511115,"version":"3.55.0"},"reference-count":8,"publisher":"SMC Media","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>This report describes a rare case of oligometastatic renal disease in a 69 year-old Caucasian male with non-small cell lung cancer (NSCLC). Diagnosed with Stage IIIb, NSCLC he completed chemoradiotherapy followed by 1 year of immunotherapy. Surveillance CT scans after nearly three years showed an ill-defined lesion in the left kidney. Biopsy results were consistent with metastasis from the known lung carcinoma. Following neo-adjuvant Pembrolizumab (200mg, q3w), the patient underwent a left radical nephrectomy, without complications. One year post-operatively, CT of the thorax, abdomen and pelvis (TAP) did not identify any recurrence. Renal metastases were historically demonstrated predominantly by autopsy studies[1]. Any mass manifesting in the kidney in the context of previous NSCLC warrants comprehensive investigations. The combination of immunotherapy followed by definitive treatment appears to be a promising management strategy[2]. With regards to local curative options, the advantages and disadvantages of surgery and radiotherapy have been well described[3-4].<\/jats:p>","DOI":"10.12890\/2023_003908","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T04:29:29Z","timestamp":1686112169000},"source":"Crossref","is-referenced-by-count":1,"title":["The changing face of lung cancer: oligometastatic renal metastasis post chemo-immunotherapy combination"],"prefix":"10.12890","volume":"10","author":[{"given":"Elvis","family":"Matini","sequence":"first","affiliation":[{"name":"Medical Oncology Department, Mercy University Hospital, Cork, T12 WE28, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trishhani","family":"Yogaretnam","sequence":"first","affiliation":[{"name":"Medical Oncology Department, Mercy University Hospital, Cork, T12 WE28, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte Alice","family":"Wilson","sequence":"first","affiliation":[{"name":"Medical Oncology Department, Mercy University Hospital, Cork, T12 WE28, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Power","sequence":"first","affiliation":[{"name":"Medical Oncology Department, Mercy University Hospital, Cork, T12 WE28, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10397","published-online":{"date-parts":[[2023,6,7]]},"reference":[{"key":"10.12890\/2023_003908_ref1","doi-asserted-by":"crossref","unstructured":"<li>Zhou C, Urbauer DL, Fellman BM, Tamboli P, Zhang M, Matin SF, et al. Metastases to the kidney: a comprehensive analysis of 151 patients from a tertiary referral centre. <em>BJU Int<\/em> 2016;<strong>117<\/strong>:775-782.<\/li>","DOI":"10.1111\/bju.13194"},{"key":"10.12890\/2023_003908_ref2","doi-asserted-by":"crossref","unstructured":"<li>Stefani D, Pl\u00f6nes T, Viehof J, Darwiche K, Stuschke M, Schuler M, et al. Lung Cancer Surgery after Neoadjuvant Immunotherapy. <em>Cancers (Basel)<\/em> 2021;<strong>13<\/strong>:4033.<\/li>","DOI":"10.3390\/cancers13164033"},{"key":"10.12890\/2023_003908_ref3","doi-asserted-by":"crossref","unstructured":"<li>Tohme S, Simmons RL, Tsung A. Surgery for Cancer: A Trigger for Metastases. <em>Cancer Res<\/em> 2017;<strong>77<\/strong>:1548-1552.<\/li>","DOI":"10.1158\/0008-5472.CAN-16-1536"},{"key":"10.12890\/2023_003908_ref4","doi-asserted-by":"crossref","unstructured":"<li>Verma V, Simone CB 2nd. Stereotactic body radiation therapy for metastases to the kidney in patients with non-small cell lung cancer: a new treatment paradigm for durable palliation. <em>Ann Palliat Med<\/em> 2017;<strong>6<\/strong>:96-103.<\/li>","DOI":"10.21037\/apm.2017.03.06"},{"key":"10.12890\/2023_003908_ref5","doi-asserted-by":"crossref","unstructured":"<li>Niu FY, Zhou Q, Yang JJ, Zhong WZ, Chen ZH, Deng W, et al. Distribution and prognosis of uncommon metastases from non-small cell lung cancer. <em>BMC Cancer<\/em> 2016;<strong>16<\/strong>:149. <\/li>","DOI":"10.1186\/s12885-016-2169-5"},{"key":"10.12890\/2023_003908_ref6","unstructured":"<li>Karagkiouzis G, Koulaxouzidis G, Tomos P, Spartalis ED, Konstantinou F, Charpidou A, et al. Solitary metastasectomy in non-small cell lung cancer. <em>J BUON<\/em> 2012;<strong>17<\/strong>:712-718.<\/li>"},{"key":"10.12890\/2023_003908_ref7","doi-asserted-by":"crossref","unstructured":"<li>Tomita M, Ayabe T, Chosa E, Nakamura K. Isolated Renal Metastasis from Non-Small-Cell Lung Cancer: Report of 2 Cases. <em>Case Rep Surg<\/em> 2015;<strong>2015<\/strong>:357481.<\/li>","DOI":"10.1155\/2015\/357481"},{"key":"10.12890\/2023_003908_ref8","doi-asserted-by":"crossref","unstructured":"<li>Craig DJ, Nanavaty NS, Devanaboyina M, Stanbery L, Hamouda D, Edelman G, et al. The abscopal effect of radiation therapy. <em>Future Oncol<\/em> 2021;<strong>17<\/strong>:1683-1694.<\/li>","DOI":"10.2217\/fon-2020-0994"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3908\/3542","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3908\/3543","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3908\/3543","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T09:09:47Z","timestamp":1755680987000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/3908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,7]]},"references-count":8,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.12890\/2023_003908","relation":{"has-manifestation":[{"id-type":"other","id":"1-102-3908-g3542","asserted-by":"subject"},{"id-type":"other","id":"1-102-3908-g3543","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-102","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"value":"2284-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,7]]}}}