{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:05:51Z","timestamp":1791579951747,"version":"4.3.4"},"reference-count":12,"publisher":"SMC Media","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Primary splenic lymphoma (PSL) is a rare disease and an improbable cause of splenomegaly or splenic nodules. On the contrary, splenic secondary involvement as part of an advanced lymphoproliferative disorder is more common. The authors present the case of a 49-year-old woman with a primary splenic diffuse large B-cell lymphoma (PS-DLBCL), in which the absence of other organs\u2019 involvement determined an ultrasound-guided biopsy of the spleen to achieve a definitive diagnosis. With this case the authors intend to emphasise the extensive differential diagnosis of splenomegaly, splenic nodules or infiltrates, the usefulness of splenic biopsy in establishing the diagnosis and recall a rare disease, with non-specific presenting symptoms, in which the diagnostic workup is challenging.<\/jats:p>","DOI":"10.12890\/2023_003932","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T09:41:02Z","timestamp":1687340462000},"source":"Crossref","is-referenced-by-count":5,"title":["Primary splenic diffuse large B-cell lymphoma: a case report"],"prefix":"10.12890","volume":"10","author":[{"given":"Nuno","family":"Maia Neves","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Hospital da Luz Lisboa, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Pestana","family":"Lopes","sequence":"first","affiliation":[{"name":"Anatomical Pathology Department, Hospital da Luz Lisboa, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Carvalho Coelho","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Hospital da Luz Lisboa, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anabela","family":"Raimundo","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Hospital da Luz Lisboa, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Manuela","family":"Mafra","sequence":"first","affiliation":[{"name":"Anatomical Pathology Department, Hospital da Luz Lisboa, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Bay\u00e3o Horta","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Hospital da Luz Lisboa, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10397","published-online":{"date-parts":[[2023,6,21]]},"reference":[{"key":"10.12890\/2023_003932_ref1","doi-asserted-by":"crossref","unstructured":"<li>Abdulbaki R, Tizro P, Nava VE, Gomes da Silva M, Ascens\u00e3o JL. Low-grade primary splenic CD10-positive small B-cell lymphoma\/follicular lymphoma. <em>Curr Oncol<\/em> 2021;<strong>28<\/strong>:4821\u20134831. <\/li>","DOI":"10.3390\/curroncol28060407"},{"key":"10.12890\/2023_003932_ref2","doi-asserted-by":"crossref","unstructured":"<li>Kim JK, Hahn JS, Kim GE, Yang W-I. Three cases of diffuse large B-cell lymphoma presenting as primary splenic lymphoma. <em>Yonsei Med J<\/em> 2005;<strong>46<\/strong>:703\u2013709.<\/li>","DOI":"10.3349\/ymj.2005.46.5.703"},{"key":"10.12890\/2023_003932_ref3","doi-asserted-by":"crossref","unstructured":"<li>Sinit RB, Dorer RK, Flores JP, Aboulafia DM. Rare causes of isolated and progressive splenic lesions: challenges in differential diagnosis, evaluation, and treatment of primary splenic lymphomas. <em>Clin Med Insights Blood Disord<\/em> 2020;<strong>13<\/strong>:1179545X20926188.<\/li>","DOI":"10.1177\/1179545X20926188"},{"key":"10.12890\/2023_003932_ref4","doi-asserted-by":"crossref","unstructured":"<li>Bairey O, Shvidel L, Perry C, Dann EJ, Ruchlemer R, Tadmor T, et al. Characteristics of primary splenic diffuse large B-cell lymphoma and role of splenectomy in improving survival. <em>Cancer<\/em> 2015;<strong>121<\/strong>:2909\u20132916.<\/li>","DOI":"10.1002\/cncr.29487"},{"key":"10.12890\/2023_003932_ref5","doi-asserted-by":"crossref","unstructured":"<li>Byrd KP, Vontela NR, McCullar B, Martin MG. Multi-database description of primary splenic diffuse large B cell lymphoma. <em>Anticancer Res<\/em> 2017;<strong>37<\/strong>:6839\u20136843.<\/li>","DOI":"10.21873\/anticanres.12145"},{"key":"10.12890\/2023_003932_ref6","doi-asserted-by":"crossref","unstructured":"<li>International Non-Hodgkin\u2019s Lymphoma Prognostic Factors Project. A predictive model for aggressive non-Hodgkin\u2019s lymphoma. <em>N Engl J Med<\/em> 1993;<strong>329<\/strong>:987\u2013994.<\/li>","DOI":"10.1056\/NEJM199309303291402"},{"key":"10.12890\/2023_003932_ref7","doi-asserted-by":"crossref","unstructured":"<li>Scott DW, Mottok A, Ennishi D, Wright GW, Farinha P, Ben-Neriah S, et al. Prognostic significance of diffuse large B-cell lymphoma cell of origin determined by digital gene expression in formalin-fixed paraffin-embedded tissue biopsies. <em>J Clin Oncol<\/em> 2015;<strong>33<\/strong>:2848\u20132856. <\/li>","DOI":"10.1200\/JCO.2014.60.2383"},{"key":"10.12890\/2023_003932_ref8","doi-asserted-by":"crossref","unstructured":"<li>Aukema SM, Siebert R, Schuuring E, van Imhoff GW, Kluin-Nelemans HC, Boerma E-J, et al. Double-hit B-cell lymphomas. <em>Blood<\/em> 2011;<strong>117<\/strong>:2319\u20132331.<\/li>","DOI":"10.1182\/blood-2010-09-297879"},{"key":"10.12890\/2023_003932_ref9","doi-asserted-by":"crossref","unstructured":"<li>Barrans S, Crouch S, Smith A, Turner K, Owen R, Patmore R, et al. Rearrangement of MYC is associated with poor prognosis in patients with diffuse large B-cell lymphoma treated in the era of rituximab. <em>J Clin Oncol<\/em> 2010;<strong>28<\/strong>:3360\u20133365.<\/li>","DOI":"10.1200\/JCO.2009.26.3947"},{"key":"10.12890\/2023_003932_ref10","doi-asserted-by":"crossref","unstructured":"<li>Johnson NA, Savage KJ, Ludkovski O, Ben-Neriah S, Woods R, Steidl C, et al. Lymphomas with concurrent BCL2 and MYC translocations: the critical factors associated with survival. <em>Blood<\/em> 2009;<strong>114<\/strong>:2273\u20132279. <\/li>","DOI":"10.1182\/blood-2009-03-212191"},{"key":"10.12890\/2023_003932_ref11","doi-asserted-by":"crossref","unstructured":"<li>Shustik J, Han G, Farinha P, Johnson NA, Ben Neriah S, Connors JM, et al. Correlations between BCL6 rearrangement and outcome in patients with diffuse large B-cell lymphoma treated with CHOP or R-CHOP. <em>Haematologica<\/em> 2010;<strong>95<\/strong>:96\u2013101.<\/li>","DOI":"10.3324\/haematol.2009.007203"},{"key":"10.12890\/2023_003932_ref12","unstructured":"<li>Capello D, Vitolo U, Pasqualucci L, Quattrone S, Migliaretti G, Fassone L, et al. Distribution and pattern of BCL-6 mutations throughout the spectrum of B-cell neoplasia. <em>Blood<\/em> 2000;<strong>95<\/strong>:651\u2013659.<\/li>"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3932\/3558","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3932\/3559","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3932\/3559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T09:09:26Z","timestamp":1755680966000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/3932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,21]]},"references-count":12,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.12890\/2023_003932","relation":{"has-manifestation":[{"id-type":"other","id":"1-102-3932-g3558","asserted-by":"subject"},{"id-type":"other","id":"1-102-3932-g3559","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-102","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"value":"2284-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,21]]}}}