{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:22:50Z","timestamp":1784308970122,"version":"3.55.0"},"reference-count":12,"publisher":"SMC Media","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Purpose:\u00a0Flavobacterium lindanitolerans\u00a0is an environmental Gram-negative, non-spore-forming rod which is usually not considered to be a human pathogen. Isolation from human clinical samples has been described only once. We report the first case of meningoencephalitis and bacteraemia with\u00a0Flavobacterium lindanitolerans. Case description:\u00a0A 76-year-old female presented with fever, headache, alteration of mental status, marked meningism and dysarthria. A lumbar puncture demonstrated cerebrospinal fluid findings consistent with bacterial meningitis, and a broad-spectrum antibiotic therapy was initiated. Blood and cerebrospinal fluid cultures revealed a growth of\u00a0Flavobacterium lindanitolerans. Based on antimicrobial susceptibilities testing, antibiotic treatment was changed to levofloxacin, resulting in a remission of the clinical symptoms after 21 days of treatment. Conclusion:\u00a0Flavobacterium\u00a0species are extremely rare human pathogens. However, some of them have been reported to cause opportunistic infections. We describe the first case of meningoencephalitis and bacteraemia caused by\u00a0Flavobacterium lindanitolerans\u00a0which was effectively treated with levofloxacin for 21 days.<\/jats:p>","DOI":"10.12890\/2023_003980","type":"journal-article","created":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T08:30:20Z","timestamp":1689237020000},"source":"Crossref","is-referenced-by-count":9,"title":["First case of meningoencephalitis and bacteraemia with Flavobacterium lindanitolerans"],"prefix":"10.12890","volume":"10","author":[{"given":"Rebecca","family":"Zurbuchen","sequence":"first","affiliation":[{"name":"Department of Medicine, Thun Hospital, Thun, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam","family":"de Roche","sequence":"first","affiliation":[{"name":"Department of Medicine, Thun Hospital, Thun, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikaterini","family":"Galimanis","sequence":"first","affiliation":[{"name":"Department of Medicine, Thun Hospital, Thun, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Narr","sequence":"first","affiliation":[{"name":"Viollier AG, Allschwil, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Dubuis","sequence":"first","affiliation":[{"name":"Viollier AG, Allschwil, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Resch","sequence":"first","affiliation":[{"name":"Department of Medicine, Thun Hospital, Thun, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mairi","family":"Ziaka","sequence":"first","affiliation":[{"name":"Department of Medicine, Thun Hospital, Thun, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10397","published-online":{"date-parts":[[2023,7,13]]},"reference":[{"key":"10.12890\/2023_003980_ref1","doi-asserted-by":"crossref","unstructured":"<li>Tunkel AR, Hasbun R, Bhimraj A, Byers K, Kaplan SL, Scheld WM, et al. Infectious Diseases Society of America's Clinical Practice Guidelines for Healthcare-Associated Ventriculitis and Meningitis. <em>Clin Infect Dis<\/em> 2017;<strong>64<\/strong>:e34\u2013e65.<\/li>","DOI":"10.1093\/cid\/ciw861"},{"key":"10.12890\/2023_003980_ref2","unstructured":"<li>Bernardet JF, Bowman JP. The genus Flavobacterium. In: Dworkin M, Falkow S, Rosenberg E, Schleifer KH, Stackebrandt E, editors. The prokaryotes: a handbook on the biology of bacteria. 3rd ed. New York: Springer, 2006:455\u2013480.<\/li>"},{"key":"10.12890\/2023_003980_ref3","doi-asserted-by":"crossref","unstructured":"<li>Loch, TP, Faisal M. Emerging flavobacterial infections in fish: a review. <em>J Adv Res<\/em> 2015;<strong>6<\/strong>:283\u2013300. <\/li>","DOI":"10.1016\/j.jare.2014.10.009"},{"key":"10.12890\/2023_003980_ref4","doi-asserted-by":"crossref","unstructured":"<li>Vela AI, Fernandez A, S\u00e1nchez-Porro C, Sierra E, Mendez M, Arbelo M, et al. Flavobacterium ceti sp. nov., isolated from beaked whales (Ziphius cavirostris). <em>Int J Syst Evol Microbiol<\/em> 2007;<strong>57<\/strong>:2604\u20132608.<\/li>","DOI":"10.1099\/ijs.0.65154-0"},{"key":"10.12890\/2023_003980_ref5","doi-asserted-by":"crossref","unstructured":"<li>Sung JY, Kim TS, Shin S, Roh EY, Yoon JH, Kim E-C. Flavobacterium ceti from blood samples of a Korean patient with alcoholic liver cirrhosis. <em>Ann Lab Med<\/em> 2015;<strong>35<\/strong>:384\u2013386.<\/li>","DOI":"10.3343\/alm.2015.35.3.384"},{"key":"10.12890\/2023_003980_ref6","unstructured":"<li>Tian GZ, Piao DR, Zhao HY, Jiang H, Cui BY, Li JY. A Flavobacterium lindanitolerans strain isolated from the ascites sample of a Chinese patient with EV71 virus infection. <em>Biomed Environ Sci<\/em> 2011;<strong>24<\/strong>:694\u2013696.<\/li>"},{"key":"10.12890\/2023_003980_ref7","doi-asserted-by":"crossref","unstructured":"<li>Park S-K, Ryoo N. A case of Flavobacterium ceti meningitis. <em>Ann Lab Med<\/em> 2016;<strong>36<\/strong>:614\u2013616. <\/li>","DOI":"10.3343\/alm.2016.36.6.614"},{"key":"10.12890\/2023_003980_ref8","doi-asserted-by":"crossref","unstructured":"<li>Mosayebi Z, Movahedian AH, Soori T. Flavobacterium sepsis outbreak due to contaminated distilled water in a neonatal intensive care unit. <em>J Hosp Infect<\/em> 2011;<strong>78<\/strong>:214\u2013215.<\/li>","DOI":"10.1016\/j.jhin.2010.11.022"},{"key":"10.12890\/2023_003980_ref9","doi-asserted-by":"crossref","unstructured":"<li>Hasbun R. Healthcare-associated ventriculitis: current and emerging diagnostic and treatment strategies. <em>Expert Rev Anti Infect Ther<\/em> 2021;<strong>19<\/strong>:993\u2013999.<\/li>","DOI":"10.1080\/14787210.2021.1866544"},{"key":"10.12890\/2023_003980_ref10","doi-asserted-by":"crossref","unstructured":"<li>Jit S, Dadhwal M, Prakash O, Lal R. Flavobacterium lindanitolerans sp. nov., isolated from hexachlorocyclohexane-contaminated soil. <em>Int J Syst Evol Microbiol<\/em> 2008;<strong>58<\/strong>:1665\u20131669.<\/li>","DOI":"10.1099\/ijs.0.65578-0"},{"key":"10.12890\/2023_003980_ref11","doi-asserted-by":"crossref","unstructured":"<li>LaFrentz BR, Kr\u00e1lov\u00e1 S, Burbick CR, Alexander TL, Phillips CW, Griffin MJ, et al. The fish pathogen Flavobacterium columnare represents four distinct species: Flavobacterium columnare, Flavobacterium covae sp. nov., Flavobacterium davisii sp. nov. and Flavobacterium oreochromis sp. nov., and emended description of Flavobacterium columnare. <em>Syst Appl Microbiol<\/em> 2022;<strong>45<\/strong>:126293. <\/li>","DOI":"10.1016\/j.syapm.2021.126293"},{"key":"10.12890\/2023_003980_ref12","doi-asserted-by":"crossref","unstructured":"<li>Maranchick NF, Alshaer MH, Smith AGC, Avaliani T, Gujabidze M, Bakuradze T, et al. Cerebrospinal fluid concentrations of fluoroquinolones and carbapenems in tuberculosis meningitis. <em>Front Pharmacol<\/em> 2022;<strong>13<\/strong>:1048653.<\/li>","DOI":"10.3389\/fphar.2022.1048653"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3980\/3578","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3980\/3576","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3980\/3576","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T08:42:14Z","timestamp":1755679334000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/3980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,13]]},"references-count":12,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.12890\/2023_003980","relation":{"has-manifestation":[{"id-type":"other","id":"1-103-3980-g3578","asserted-by":"subject"},{"id-type":"other","id":"1-103-3980-g3576","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-103","asserted-by":"subject"}],"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-2884736\/v1","asserted-by":"object"}]},"ISSN":["2284-2594"],"issn-type":[{"value":"2284-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,13]]}}}