{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T18:18:42Z","timestamp":1755800322785,"version":"3.44.0"},"reference-count":10,"publisher":"SMC Media","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Central nervous system (CNS) lymphoma is a rare and aggressive primary neoplasm that comprises a small proportion of brain tumours and non-Hodgkin lymphomas. We present a case report of a 64-year-old woman with CNS lymphoma, who exhibited cognitive changes, weight loss and neurological symptoms. Imaging scans revealed multiple lesions in the brain and thrombosis in the venous sinuses. A diagnosis of diffuse large B-cell lymphoma of the CNS was confirmed through histological examination. The patient underwent treatment with corticosteroids and chemotherapy, but experienced clinical deterioration with thrombocytopenia and disease progression. Despite efforts to manage complications and provide targeted therapy, the patient passed away. Primary CNS lymphoma typically responds well to chemotherapy, and prognostic factors such as age and functional status play a significant role in patient outcomes. However, complications such as thromboembolism pose challenges during treatment due to the hypercoagulable state induced by chemotherapy agents. The pathophysiology of thromboembolic events in the context of malignancy remains uncertain but may involve direct tumour compression, vascular invasion and alterations in coagulation factors. The diagnostic process for CNS lymphoma can be complex, and the information obtained from cerebrospinal fluid analysis, including flow cytometry, may be limited in cases with low cell counts. Ongoing research exploring genetic tests and biomarkers shows promise for improving diagnostic accuracy in such cases. This case underscores the need for comprehensive management strategies that address both the neoplasm and its associated complications, to optimise patient outcomes.<\/jats:p>","DOI":"10.12890\/2023_003994","type":"journal-article","created":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T17:33:41Z","timestamp":1690652021000},"source":"Crossref","is-referenced-by-count":1,"title":["Primary central nervous system lymphoma complicated by cerebral venous sinus thrombosis: a case report"],"prefix":"10.12890","volume":"10","author":[{"given":"Teresa","family":"Medeiros","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Hospital Pedro Hispano, ULSM, Matosinhos, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Sequeira","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Hospital do Santo Esp\u00edrito da Ilha Terceira, Ilha Terceira, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Mendes","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Hospital Pedro Hispano, ULSM, Matosinhos, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1tima","family":"Hierro","sequence":"first","affiliation":[{"name":"Department of Neuroradiology, Hospital Pedro Hispano, ULSM, Matosinhos, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Duarte","sequence":"first","affiliation":[{"name":"Department of Neurology, Hospital Pedro Hispano, ULSM, Matosinhos, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2023,7,28]]},"reference":[{"key":"10.12890\/2023_003994_ref1","doi-asserted-by":"crossref","unstructured":"<li>Logothetis CN, Pizanis C. Cerebral venous thrombosis in the setting of malignancy: case report and review of the literature. <em>Case Rep Hematol<\/em> 2020; <strong>17<\/strong>:8849252.<\/li>","DOI":"10.1155\/2020\/8849252"},{"key":"10.12890\/2023_003994_ref2","doi-asserted-by":"crossref","unstructured":"<li>Yuen HLA, Slocombe A, Heron V, Chunilal S, Shortt J, Tatarczuch M, et al. Venous thromboembolism in primary central nervous system lymphoma during frontline chemoimmunotherapy. <em>Res Pract Thromb Haemost<\/em>. 2020; <strong>23<\/strong>:997\u20131003.<\/li>","DOI":"10.1002\/rth2.12415"},{"key":"10.12890\/2023_003994_ref3","doi-asserted-by":"crossref","unstructured":"<li>Saito M, Wages NA, Schiff D. Incidence, risk factors and management of venous thromboembolism in patients with primary CNS lymphoma. <em>J Neurooncol<\/em> 2021;<strong>154<\/strong>:41-47.<\/li>","DOI":"10.1007\/s11060-021-03791-x"},{"key":"10.12890\/2023_003994_ref4","doi-asserted-by":"crossref","unstructured":"<li>Nayak L, Grommes C. Neurologic complications of lymphoma. In: Schiff D, Arrillaga I, Wen P, editors. Cancer neurology in clinical practice: neurological complications of cancer and its treatment. Cham: Springer, 2018:571\u2013581.<\/li>","DOI":"10.1007\/978-3-319-57901-6_31"},{"key":"10.12890\/2023_003994_ref5","doi-asserted-by":"crossref","unstructured":"<li>Bellesso M, Bizzetto R, Pereira J, Beitler B, Pracchia LF, Chamone DAS. Linfoma prim\u00e1rio do sistema nervoso central. [Primary central nervous system lymphoma.]. <em>Rev Bras Hematol Hemoter<\/em> 2008;<strong>30<\/strong>:54\u2013 60.<\/li>","DOI":"10.1590\/S1516-84842008000100013"},{"key":"10.12890\/2023_003994_ref6","doi-asserted-by":"crossref","unstructured":"<li>Ferreri AJM, Calimeri T, Lopedote P, Francaviglia I, Daverio R, Iacona C, et al. MYD88 L265P mutation and interleukin-10 detection in cerebrospinal fluid are highly specific discriminating markers in patients with primary central nervous system lymphoma: results from a prospective study. <em>Br J Haematol<\/em> 2021;<strong>193<\/strong>:497\u2013505.<\/li>","DOI":"10.1111\/bjh.17357"},{"key":"10.12890\/2023_003994_ref7","doi-asserted-by":"crossref","unstructured":"<li>Quijano S, L\u00f3pez A, Sancho JM, Panizo C, Deb\u00e9n G, Castilla C, et al. Identification of leptomeningeal disease in aggressive B-cell non-Hodgkin\u2019s lymphoma: improved sensitivity of flow cytometry. <em>J Clin Oncol<\/em> 2009;<strong>27<\/strong>:1462\u20131469.<\/li>","DOI":"10.1200\/JCO.2008.17.7089"},{"key":"10.12890\/2023_003994_ref8","doi-asserted-by":"crossref","unstructured":"<li>Sierra del Rio M, Rousseau A, Soussain C, Ricard D, Hoang-Xuan K. Primary CNS lymphoma in immunocompetent patients. <em>Oncologist<\/em> 2009;<strong>14<\/strong>:526\u2013539.<\/li>","DOI":"10.1634\/theoncologist.2008-0236"},{"key":"10.12890\/2023_003994_ref9","doi-asserted-by":"crossref","unstructured":"<li>Biswas A, Adhikari N, Bakhshi S, Gopinathan VR, Sharma MC. A rare case of primary central nervous system lymphoma in an adolescent female treated with high-dose methotrexate and rituximab-based chemoimmunotherapy and consolidation whole brain radiotherapy. <em>Pediatr Neurosurg<\/em> 2019:<strong>54<\/strong>:57\u201365.<\/li>","DOI":"10.1159\/000495789"},{"key":"10.12890\/2023_003994_ref10","doi-asserted-by":"crossref","unstructured":"<li>Ahn Y, Ahn HJ, Yoon DH, Hong JY, Yoo C, Kim S, et al. Primary central nervous system lymphoma: a new prognostic model for patients with diffuse large B-cell histology. <em>Blood Res<\/em> 2017:<strong>52<\/strong>:285\u2013292.<\/li>","DOI":"10.5045\/br.2017.52.4.285"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3994\/3590","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3994\/3591","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3994\/3591","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T08:42:01Z","timestamp":1755679321000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/3994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,28]]},"references-count":10,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.12890\/2023_003994","relation":{"has-manifestation":[{"id-type":"other","id":"1-103-3994-g3590","asserted-by":"subject"},{"id-type":"other","id":"1-103-3994-g3591","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-103","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2023,7,28]]}}}