{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:45:35Z","timestamp":1790700335260,"version":"4.1.0"},"reference-count":14,"publisher":"SMC Media","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Introduction:\u00a0Pantoprazole is one of the most widely used proton pump inhibitors, but anaphylaxis occurs rarely during its use. The purpose of reporting these two cases is to show that pantoprazole is not a drug without problems; it can also cause anaphylactic reactions. Cases description:\u00a0A 42-year-old woman presented to the emergency department due to dyspeptic complaints. Immediately at the end of the infusion of pantoprazole, there started to be numbness of the tongue, itching all over the body, and difficulty in breathing. Half an hour after taking a pantoprazole 40 mg capsule, a 58-year-old woman started to experience redness of the face, thickening of the tongue, itching, bloating, and dizziness. Arterial pressure was 80\/60 mmHg, pulse 150\/minute, while saturation had dropped to 88%. In both cases, fluids, adrenaline, antihistamines, methylprednisolone, and calcium were immediately started. After the improvement of their general conditions, both patients were discharged home. Discussion:\u00a0The first case relates to anaphylaxis after the intravenous administration of pantoprazole, and the second case relates to the appearance of anaphylaxis after its oral administration. Conclusion:\u00a0Health workers need to be informed about the possibility of anaphylaxis in patients taking both oral and parenteral pantoprazole.<\/jats:p>","DOI":"10.12890\/2023_004017","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T05:23:38Z","timestamp":1691731418000},"source":"Crossref","is-referenced-by-count":4,"title":["Anaphylaxis caused by taking pantoprazole: case series"],"prefix":"10.12890","volume":"10","author":[{"given":"Skender","family":"Telaku","sequence":"first","affiliation":[{"name":"University for Business and Technology, Prishtina, Kosovo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arber","family":"Veliu","sequence":"first","affiliation":[{"name":"University and Clinical Center of Kosova, Gastroenterology Department, Kosovo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qendrim","family":"Zenelaj","sequence":"first","affiliation":[{"name":"University and Clinical Center of Kosova, Gastroenterology Department, Kosova"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mimoza","family":"Telaku","sequence":"first","affiliation":[{"name":"Medical Faculty, Tirana, Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajrullah","family":"Fejza","sequence":"first","affiliation":[{"name":"University for Business and Technology, Prishtina, Kosovo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fitim","family":"Alidema","sequence":"first","affiliation":[{"name":"University for Business and Technology, Prishtina, Kosova"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10397","published-online":{"date-parts":[[2023,8,10]]},"reference":[{"key":"10.12890\/2023_004017_ref1","doi-asserted-by":"crossref","unstructured":"<li>Thomson AB, Sauve MD, Kassam N, Kamitakahara H. Safety of the long-term use of proton pump inhibitors. <em>World J Gastroenterol<\/em> 2010;<strong>16<\/strong>:2323\u20132330. <\/li>","DOI":"10.3748\/wjg.v16.i19.2323"},{"key":"10.12890\/2023_004017_ref2","doi-asserted-by":"crossref","unstructured":"<li>Natsch S, Vinks MH, Voogt AK, Mees EB, Meyboom RH. Anaphylactic reactions to proton-pump inhibitors. <em>Ann Pharmacother<\/em> 2000;<strong>34<\/strong>:474\u2013476. <\/li>","DOI":"10.1345\/1542-6270(2000)034<0474:ARTPPI>2.3.CO;2"},{"key":"10.12890\/2023_004017_ref3","doi-asserted-by":"crossref","unstructured":"<li>S\u00e1nchez-Borges M, Gonz\u00e1lez-Aveledo L. Exfoliative erythrodermia induced by pantoprazole. <em>Allergol Immunopathol (Madr)<\/em> 2012;<strong>40<\/strong>:194\u2013195. <\/li>","DOI":"10.1016\/j.aller.2011.03.006"},{"key":"10.12890\/2023_004017_ref4","doi-asserted-by":"crossref","unstructured":"<li>Gonz\u00e1lez P, Soriano V, L\u00f3pez P, Niveiro E. Anaphylaxis to proton pump inhibitors. <em>Allergol Immunopathol (Madr)<\/em> 2002;<strong>30<\/strong>:342\u2013343.<\/li>","DOI":"10.1016\/S0301-0546(02)79150-7"},{"key":"10.12890\/2023_004017_ref5","doi-asserted-by":"crossref","unstructured":"<li>Gupta PP, Bhandari R, Mishra DR, Agrawal KK, Bhandari R, Jirel S, et al. Anaphylactic reactions due to pantoprazole: case report of two cases. <em>Int Med Case Rep J<\/em> 2018;<strong>11<\/strong>:125\u2013127. <\/li>","DOI":"10.2147\/IMCRJ.S153099"},{"key":"10.12890\/2023_004017_ref6","unstructured":"<li>Yadav A, Das I, Yadav D. A rare case of pantoprazole induced anaphylactic shock. <em>Current Research<\/em> 2019;<strong>11<\/strong>:7522\u20137523.<\/li>"},{"key":"10.12890\/2023_004017_ref7","doi-asserted-by":"crossref","unstructured":"<li>Alolabi R, Liem JJ. Pantoprazole-induced anaphylaxis. <em>J Allergy Clin Immunol<\/em> 2019;<strong>143<\/strong>:AB73.<\/li>","DOI":"10.1016\/j.jaci.2018.12.227"},{"key":"10.12890\/2023_004017_ref8","doi-asserted-by":"crossref","unstructured":"<li>Kepil \u00d6zdemir S, \u00d6ner Erkekol F, \u00dcnal D, B\u00fcy\u00fck\u00f6zt\u00fcrk S, Gelincik A, Dursun AB, Karakaya, et al. Management of hypersensitivity reactions to proton pump inhibitors: a retrospective experience. <em>Int Arch Allergy Immunol<\/em> 2016;<strong>171<\/strong>:54\u201360.<\/li>","DOI":"10.1159\/000450952"},{"key":"10.12890\/2023_004017_ref9","unstructured":"<li>G\u00e1zquez V, Dalmau G, Gaig P, G\u00f3mez C, Navarro S, Merc\u00e9 J. Kounis syndrome: report of 5 cases. <em>J Investig Allergol Clin Immunol<\/em> 2010;<strong>20<\/strong>:162\u2013165.<\/li>"},{"key":"10.12890\/2023_004017_ref10","unstructured":"<li>Faridaalaee G, Heris JA. 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Anaphylaxis as a side effect of pantoprazole. <em>Shiraz E-Med J<\/em> 2020;<strong>21<\/strong>:e97458.<\/li>","DOI":"10.5812\/semj.97458"},{"key":"10.12890\/2023_004017_ref14","doi-asserted-by":"crossref","unstructured":"<li>James J, Rani J, Sathyanarayanan V, Begum A, Fayaz SH. 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