{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T08:22:45Z","timestamp":1765354965303,"version":"3.44.0"},"reference-count":6,"publisher":"SMC Media","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Background:\u00a0Linezolid is known to cause side effects, including nausea, diarrhea, and headaches of short duration. As extended use of linezolid is becoming more common, additional rare side effects should be considered. Case Presentation:\u00a0A 68-year-old man hospitalized for osteomyelitis developed severe abdominal pain and altered mental status following five weeks of linezolid therapy. Laboratory studies showed very high lipase levels, lactic acidosis not responding to resuscitation, and relative hypoglycemia. All common causes of pancreatitis were ruled out, and a trial of linezolid withdrawal was done resulting in drastic improvement in the patient's clinical status. Conclusions:\u00a0For patients on extended course of linezolid who develop abdominal pain, drug-induced pancreatitis should be considered as a side effect, and a trial of withdrawal of linezolid should be undertaken.<\/jats:p>","DOI":"10.12890\/2023_004041","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T06:21:54Z","timestamp":1693462914000},"source":"Crossref","is-referenced-by-count":4,"title":["Linezolid-induced pancreatitis associated with lactic acidosis and relative hypoglycemia: A rare case report"],"prefix":"10.12890","volume":"10","author":[{"given":"Gi Eun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soubiya","family":"Ansari","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ateeque","family":"Ali","sequence":"first","affiliation":[{"name":"Weill Cornell Medicine-Qatar, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ehab","family":"Adams","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mugahid","family":"Eltahir","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar; Department of Medical Intensive Care Unit, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2023,8,31]]},"reference":[{"key":"10.12890\/2023_004041_ref1","doi-asserted-by":"crossref","unstructured":"<li>Hashemian SM, Farhadi T, Ganjparvar M. Linezolid: a review of its properties, function, and use in critical care. <em>DDDT<\/em> 2018;<strong>12<\/strong>:1759\u20131767.<\/li>","DOI":"10.2147\/DDDT.S164515"},{"key":"10.12890\/2023_004041_ref2","doi-asserted-by":"crossref","unstructured":"<li>Tobias PE, Varughese CA, Hanson AP, Gurnani PK. A Case of Linezolid Induced Toxicity. <em>J Pharm Pract<\/em> 2020;<strong>33<\/strong>:222-225. <\/li>","DOI":"10.1177\/0897190018782787"},{"key":"10.12890\/2023_004041_ref3","doi-asserted-by":"crossref","unstructured":"<li>Johnson PC, Vaduganathan M, Phillips KM, O'Donnell WJ. A triad of linezolid toxicity: hypoglycemia, lactic acidosis, and acute pancreatitis. <em>Proc (Bayl Univ Med Cent)<\/em> 2015;<strong>28<\/strong>:466-468. <\/li>","DOI":"10.1080\/08998280.2015.11929310"},{"key":"10.12890\/2023_004041_ref4","doi-asserted-by":"crossref","unstructured":"<li>Rose PC, Hallbauer UM, Seddon JA, Hesseling AC, Schaaf HS. Linezolid-containing regimens for the treatment of drug-resistant tuberculosis in South African children. <em>Int J Tuberc Lung Dis<\/em> 2012;<strong>16<\/strong>:1588-1593. <\/li>","DOI":"10.5588\/ijtld.12.0322"},{"key":"10.12890\/2023_004041_ref5","doi-asserted-by":"crossref","unstructured":"<li>Wolfe D, Kanji S, Yazdi F, Barbeau P, Rice D, Beck A, et al. Drug induced pancreatitis: A systematic review of case reports to determine potential drug associations. <em>PLoS One<\/em> 2020;<strong>15<\/strong>:e0231883.<\/li>","DOI":"10.1371\/journal.pone.0231883"},{"key":"10.12890\/2023_004041_ref6","doi-asserted-by":"crossref","unstructured":"<li>Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reactions. <em>Clin Pharmacol Ther<\/em> 1981;<strong>30<\/strong>:239.<\/li>","DOI":"10.1038\/clpt.1981.154"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/4041\/3640","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/4041\/3641","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/4041\/3641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T07:50:12Z","timestamp":1755676212000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/4041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,31]]},"references-count":6,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.12890\/2023_004041","relation":{"has-manifestation":[{"id-type":"other","id":"1-105-4041-g3640","asserted-by":"subject"},{"id-type":"other","id":"1-105-4041-g3641","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-105","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2023,8,31]]}}}