{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:35:36Z","timestamp":1788446136181,"version":"build-2803163510"},"reference-count":6,"publisher":"SMC Media","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Kikuchi-Fujimoto disease (KFD), also called histiocytic necrotizing lymphadenitis, is more common in young women and typically presents with small, painful, localized cervical lymphadenopathy that resolves spontaneously within a few weeks. Laboratory findings are variable. As many as 40% of KFD cases are reported to be painless, and up to 22% to be generalized lymphadenopathy. Therefore, malignant lymphoma could be a differential diagnosis of KFD. A histopathologic diagnosis is needed when it is difficult to distinguish KFD from lymphoma. KFD typically shows small, highly accumulated cervical lymph nodes on fluorodeoxyglucose positron emission tomography (FDG-PET). This contrasts with malignant lymphoma, which tends to be associated with massive lymphadenopathy. In our case, a 40-year-old Japanese male presented with painless lumps in the right neck, accompanied by fever, night sweats, and loss of appetite. His symptoms and laboratory results worsened over a month. FDG-PET revealed highly accumulated uptake in cervical, mediastinal, and axillary lymph nodes. The PET imaging showed a small, high FDG uptake and contributed to the correct diagnosis of KFD. This case report highlights the importance of FDG-PET, which is a valuable diagnostic tool for KFD as it typically differentiates large clusters of small lymph nodes typical of KFD from normal lymph nodes.<\/jats:p>","DOI":"10.12890\/2024_004258","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T06:42:41Z","timestamp":1706164961000},"source":"Crossref","is-referenced-by-count":1,"title":["Atypical Kikuchi-Fujimoto disease: FDG-PET contribution to the diagnosis"],"prefix":"10.12890","volume":"11","author":[{"given":"Mutsuka","family":"Kurihara","sequence":"first","affiliation":[{"name":"Department of General Medicine, Chiba University Hospital, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasutaka","family":"Yanagita","sequence":"first","affiliation":[{"name":"Department of General Medicine, Chiba University Hospital, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiki","family":"Yokokawa","sequence":"first","affiliation":[{"name":"Department of General Medicine, Chiba University Hospital, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Li","sequence":"first","affiliation":[{"name":"Department of General Medicine, Chiba University Hospital, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatomi","family":"Ikusaka","sequence":"first","affiliation":[{"name":"Department of General Medicine, Chiba University Hospital, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10397","published-online":{"date-parts":[[2024,1,25]]},"reference":[{"key":"10.12890\/2024_004258_ref1","doi-asserted-by":"crossref","unstructured":"<li>Perry AM, Choi SM. Kikuchi-Fujimoto Disease: A Review. <em>Arch Pathol Lab Med<\/em> 2018;<strong>142<\/strong>:1341-1346.<\/li>","DOI":"10.5858\/arpa.2018-0219-RA"},{"key":"10.12890\/2024_004258_ref2","unstructured":"<li>Kikuchi M. Lymphadenitis showing focal reticulum cell hyperplasia with nuclear debris and phagocytosis. <em>Nippon Ketsueki Gakkai Zasshi<\/em> 1972;<strong>35<\/strong>:378\u2013380.<\/li>"},{"key":"10.12890\/2024_004258_ref3","unstructured":"<li>Fujimoto Y, Kozima Y, Hamaguchi K. Cervical necrotizing lymphadenitis: a new clinicopathological agent. <em>Naika<\/em> 1972;<strong>20<\/strong>:920\u2013927.<\/li>"},{"key":"10.12890\/2024_004258_ref4","doi-asserted-by":"crossref","unstructured":"<li>Song JY, Lee J, Park DW, Sohn JW, Suh SI, Kim IS, et al. Clinical outcome and predictive factors of recurrence among patients with Kikuchi\u2019s disease. <em>Int J Infect Dis<\/em> 2009;<strong>13<\/strong>:322-326.<\/li>","DOI":"10.1016\/j.ijid.2008.06.022"},{"key":"10.12890\/2024_004258_ref5","doi-asserted-by":"crossref","unstructured":"<li>Supari D, Ananthamurthy A. Kikuchi-Fujimoto disease: a study of 24 cases. <em>Indian J Otolaryngol Head Neck Surg<\/em> 2014;<strong>66<\/strong>:69\u201373.<\/li>","DOI":"10.1007\/s12070-013-0672-4"},{"key":"10.12890\/2024_004258_ref6","doi-asserted-by":"crossref","unstructured":"<li>Wang S, Du B, Li X, Li Y. Positron emission tomography\/computed tomography hypermetabolism of Kikuchi-Fujimoto disease mimicking malignant lymphoma: a case report and literature review. <em>J Int Med Res<\/em> 2021;<strong>49<\/strong>:3000605211032859.<\/li>","DOI":"10.1177\/03000605211032859"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/4258\/3823","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/4258\/3824","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/4258\/3824","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T15:07:18Z","timestamp":1755616038000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/4258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,25]]},"references-count":6,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.12890\/2024_004258","relation":{"has-manifestation":[{"id-type":"other","id":"1-109-4258-g3823","asserted-by":"subject"},{"id-type":"other","id":"1-109-4258-g3824","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-109","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"value":"2284-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,25]]}}}