{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T17:49:46Z","timestamp":1755798586288,"version":"3.44.0"},"reference-count":7,"publisher":"SMC Media","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Ulcerative colitis (UC) is an autoimmune disease associated with both intestinal and extraintestinal manifestations. The latter may include heart complications, such as myopericarditis leading to life-threatening arrythmias. Nowadays, UC is commonly treated with biologic medications and infliximab is the first line therapy in an outpatient setting, while it is also used as rescue therapy in acute severe UC. However, it has been associated with severe immunosuppression, cytomegalovirus (CMV) reactivation and drug-induced hepatitis. We report a case of UC flare in a biologic na\u00efve patient admitted with myopericarditis, which was further complicated by positive CMV biopsies and infliximab-induced transaminitis.<\/jats:p>","DOI":"10.12890\/2024_004383","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T06:50:18Z","timestamp":1709535018000},"source":"Crossref","is-referenced-by-count":1,"title":["Acute severe ulcerative colitis flare complicated by myopericarditis and infliximab-induced hepatitis"],"prefix":"10.12890","volume":"11","author":[{"given":"Magdalini","family":"Manti","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, St Mark\u2019s Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos Kamperidis","family":"Nikolaos Kamperidis","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, St Mark\u2019s Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandros Toskas","family":"Alexandros Toskas","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, St Mark\u2019s Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry Martin","family":"Harry Martin","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, St Mark\u2019s Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi Misra","family":"Ravi Misra","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, St Mark\u2019s Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2024,3,1]]},"reference":[{"key":"10.12890\/2024_004383_ref1","doi-asserted-by":"crossref","unstructured":"<li>Bunu D-M, Timofte C-E, Ciocoiu M, Floria M, Tarniceriu C-C, Barboi O-B, et al. Cardiovascular manifestations of inflammatory bowel disease: pathogenesis, diagnosis, and preventive strategies. <em>Gastroenterol Res Pract<\/em> 2019;<strong>2019<\/strong>:3012509.<\/li>","DOI":"10.1155\/2019\/3012509"},{"key":"10.12890\/2024_004383_ref2","doi-asserted-by":"crossref","unstructured":"<li>Bhardwaj A, Singh A, Midha V, Sood A, Wander GS, Mohan B, et al. Cardiovascular implications of inflammatory bowel disease: an updated review. <em>World J Cardiol<\/em> 2023;<strong>15<\/strong>:553\u2013570.<\/li>","DOI":"10.4330\/wjc.v15.i11.553"},{"key":"10.12890\/2024_004383_ref3","doi-asserted-by":"crossref","unstructured":"<li>Giordani AS, Candelora A, Fiacca M, Cheng C, Barberio B, Baritussio A, et al. Myocarditis and inflammatory bowel diseases: a single-center experience and a systematic literature review. <em>Int J Cardiol<\/em> 2023;<strong>376<\/strong>:165\u2013171.<\/li>","DOI":"10.1016\/j.ijcard.2023.01.071"},{"key":"10.12890\/2024_004383_ref4","doi-asserted-by":"crossref","unstructured":"<li>Hedin CRH, Vavricka SR, Stagg AJ, Schoepfer A, Raine T, Puig L, et al. The pathogenesis of extraintestinal manifestations: implications for IBD research, diagnosis, and therapy. <em>J Crohns Colitis<\/em> 2019;<strong>13<\/strong>:541\u2013554.<\/li>","DOI":"10.1093\/ecco-jcc\/jjy191"},{"key":"10.12890\/2024_004383_ref5","doi-asserted-by":"crossref","unstructured":"<li>Nakase H, Herfarth H. Cytomegalovirus colitis, cytomegalovirus hepatitis and systemic cytomegalovirus infection: common features and differences. <em>Inflamm Intest Dis<\/em> 2016;<strong>1<\/strong>:15\u201323.<\/li>","DOI":"10.1159\/000443198"},{"key":"10.12890\/2024_004383_ref6","doi-asserted-by":"crossref","unstructured":"<li>Jones A, McCurdy JD, Loftus EV Jr, Bruining DH, Enders FT, Killian JM, et al. Effects of antiviral therapy for patients with inflammatory bowel disease and a positive intestinal biopsy for cytomegalovirus. <em>Clin Gastroenterol Hepatol<\/em> 2015;<strong>13<\/strong>:949\u2013955.<\/li>","DOI":"10.1016\/j.cgh.2014.09.042"},{"key":"10.12890\/2024_004383_ref7","doi-asserted-by":"crossref","unstructured":"<li>Rahier JF, Magro F, Abreu C, Armuzzi A, Ben-Horin S, Chowers Y, et al. Second European evidence-based consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease. <em>J Crohns Colitis<\/em> 2014;<strong>8<\/strong>:443\u2013468.<\/li>","DOI":"10.1016\/j.crohns.2013.12.013"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/4383\/3878","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/4383\/3879","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/4383\/3878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T10:37:34Z","timestamp":1755599854000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/4383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,1]]},"references-count":7,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.12890\/2024_004383","relation":{"has-manifestation":[{"id-type":"other","id":"1-111-4383-g3878","asserted-by":"subject"},{"id-type":"other","id":"1-111-4383-g3879","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-111","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2024,3,1]]}}}