{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T13:10:16Z","timestamp":1727874616148},"reference-count":11,"publisher":"SMC Media","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Introduction:\u00a0Solitary rectal ulcer syndrome (SURS) is a poorly understood and uncommon benign disorder of the lower gastrointestinal tract. It presents with various symptoms, often misinterpreted as inflammatory bowel disease. To date, there is no association between the use of selective serotonin reuptake inhibitors (SSRIs) and SURS. Case description:\u00a0A 29-year-old male on paroxetine for six months and with a non-contributory surgical history presented to the clinic due to three months of haematochezia, abdominal pain and mucoid discharge. Physical examination and a review of systems were unremarkable; a colonoscopy demonstrated a suspicious ulcerated lesion in the rectum, which was identified as SURS on biopsy. The patient was advised lifestyle and dietary modifications. In addition, paroxetine was discontinued, and patient was switched to venlafaxine, a serotonin\u2013norepinephrine reuptake inhibitor. Subsequently, the patient\u2019s symptoms resolved gradually, and he did not report any signs of recurrence on follow-up. Conclusion:\u00a0Literature confirms that SSRIs can increase the occurrence of GI ulceration yet focuses specifically on upper gastrointestinal bleeding rather than rectal bleeding. This finding raises the need for further research.<\/jats:p>","DOI":"10.12890\/2024_004826","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T09:09:02Z","timestamp":1726736942000},"source":"Crossref","is-referenced-by-count":0,"title":["Selective serotonin reuptake inhibitors and solitary rectal ulcer syndrome: a bloody relationship"],"prefix":"10.12890","author":[{"given":"Nicolas","family":"Moussallem","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Medical Sciences, University of Balamand, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaelle-Christie","family":"Haddad","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Medical Sciences, University of Balamand, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Sbeih","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Medical Sciences, University of Balamand, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karam","family":"Karam","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, University of Balamand, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elias","family":"Fiani","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, University of Balamand, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2024,9,19]]},"reference":[{"unstructured":"<li>Abusharifah O, Bokhary RY, Mosli MH, Saadah OI. Solitary rectal ulcer syndrome in children and adolescents: a descriptive clinicopathologic study. <em>Int J Clin Exp Pathol<\/em> 2021;<strong>14<\/strong>:399\u2013407. <\/li>","key":"10.12890\/2024_004826_ref1"},{"doi-asserted-by":"crossref","unstructured":"<li>Sadeghi A, Biglari M, Forootan M, Adibi P. Solitary rectal ulcer syndrome: a narrative review. <em>Middle East J Dig Dis<\/em> 2019;<strong>11<\/strong>:129\u2013134. <\/li>","key":"10.12890\/2024_004826_ref2","DOI":"10.15171\/mejdd.2019.138"},{"doi-asserted-by":"crossref","unstructured":"<li>Liu Y, Chen Z, Dou L, Yang Z, Wang G. Solitary rectal ulcer syndrome is not always ulcerated: a case report. <em>Medicina (Kaunas)<\/em> 2022;<strong>58<\/strong>:1136. <\/li>","key":"10.12890\/2024_004826_ref3","DOI":"10.3390\/medicina58081136"},{"doi-asserted-by":"crossref","unstructured":"<li>Forootan M, Darvishi M. Solitary rectal ulcer syndrome: a systematic review. <em>Medicine (Baltimore)<\/em> 2018;<strong>97<\/strong>:e0565. 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Selective serotonin reuptake inhibitor use and risk of gastrointestinal and intracranial bleeding. <em>J Am Osteopath Assoc<\/em> 2019;<strong>119<\/strong>:102\u2013111.<\/li>","key":"10.12890\/2024_004826_ref9","DOI":"10.7556\/jaoa.2019.016"},{"doi-asserted-by":"crossref","unstructured":"<li>Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method of estimating the probability of adverse drug reactions. <em>Clin Pharmacol Ther<\/em> 1981;<strong>30<\/strong>:239\u2013245. <\/li>","key":"10.12890\/2024_004826_ref10","DOI":"10.1038\/clpt.1981.154"},{"doi-asserted-by":"crossref","unstructured":"<li>Gouriou C, Siproudhis L, Chambaz, M, Ropert A, Wallenhorst T, Merlini-l\u2019H\u00e9ritier A, et al. Solitary rectal ulcer syndrome in 102 patients: do different phenotypes make sense? <em>Dig Liver Dis<\/em> 2021;<strong>53<\/strong>:190\u2013195.<\/li>","key":"10.12890\/2024_004826_ref11","DOI":"10.1016\/j.dld.2020.10.041"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/4826\/4263","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/4826\/4264","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/4826\/4264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T12:50:53Z","timestamp":1727873453000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/4826"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,19]]},"references-count":11,"URL":"https:\/\/doi.org\/10.12890\/2024_004826","relation":{"has-manifestation":[{"id-type":"other","id":"1-118-4826-g4263","asserted-by":"subject"},{"id-type":"other","id":"1-118-4826-g4264","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-118","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2024,9,19]]}}}