{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T17:48:36Z","timestamp":1755798516392,"version":"3.44.0"},"reference-count":7,"publisher":"SMC Media","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Respiratory alkalosis is associated with central nervous system (CNS) diseases, drugs, lung diseases and others. Safinamide is a recent anti-parkinsonian drug with anti-dyskinetic properties and a good adjunct to L-dopa therapy during the activation period, with no significant adverse effects described. The authors present a case of a 71-year-old woman, with Parkinson\u2019s disease treated with levodopa\/benserazide, safinamide, amitriptyline, sertraline and diazepam. She made multiple visits to the emergency department due to progressive dyspnoea and asthenia, with primary respiratory alkalosis, which was thought to be caused by anxiety-induced hyperventilation and treated accordingly. After a comprehensive study, it was determined that the most probable cause of the respiratory alkalosis was pharmacological. There was a clinical and temporal agreement with the introduction of safinamide.<\/jats:p>","DOI":"10.12890\/2024_004886","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T05:07:19Z","timestamp":1728277639000},"source":"Crossref","is-referenced-by-count":0,"title":["Respiratory alkalosis as an adverse effect of safinamide?"],"prefix":"10.12890","volume":"11","author":[{"given":"Fl\u00e1via","family":"Freitas","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Unidade Local de Sa\u00fade Barcelos\/Esposende, Barcelos, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Rosa","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Unidade Local de Sa\u00fade Barcelos\/Esposende, Barcelos, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catarina","family":"Pinto Silva","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Unidade Local de Sa\u00fade Barcelos\/Esposende, Barcelos, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Marques","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Unidade Local de Sa\u00fade Barcelos\/Esposende, Barcelos, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o","family":"Mota","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Unidade Local de Sa\u00fade Barcelos\/Esposende, Barcelos, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Lemos Costa","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Unidade Local de Sa\u00fade Barcelos\/Esposende, Barcelos, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Oliveira","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Unidade Local de Sa\u00fade Barcelos\/Esposende, Barcelos, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2024,10,7]]},"reference":[{"key":"10.12890\/2024_004886_ref1","doi-asserted-by":"crossref","unstructured":"<li>Palmer BF, Clegg DJ. Respiratory Acidosis and Respiratory Alkalosis: Core Curriculum 2023. <em>Am J Kidney Dis<\/em> 2023;<strong>82<\/strong>:347\u2013359<\/li>","DOI":"10.1053\/j.ajkd.2023.02.004"},{"key":"10.12890\/2024_004886_ref2","unstructured":"<li>Krapf R, Hulter HN. Respiratory alkalosis. In: Gennari FJ, Adrogue HJ, Editors. Acid-Base Disorders and Their Treatment (1st ed.), CRC Press; 2005, p. 641\u2013679.<\/li>"},{"key":"10.12890\/2024_004886_ref3","doi-asserted-by":"crossref","unstructured":"<li>Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I Roberts EA et al. A method of estimating the probability of adverse drug reactions. <em>Clin.Pharmacol Ther<\/em> 1981;<strong>30<\/strong>:239-245. <\/li>","DOI":"10.1038\/clpt.1981.154"},{"key":"10.12890\/2024_004886_ref4","doi-asserted-by":"crossref","unstructured":"<li>Giossi R, Carrara F, Mazzari M, Lo Re F, Senatore M, Schicchi A, et al. Overall Efficacy and Safety of Safinamide in Parkinson\u2019s Disease: A Systematic Review and a Meta-analysis. <em>Clin Drug Investig<\/em> 2021;<strong>41<\/strong>:321\u2013339.<\/li>","DOI":"10.1007\/s40261-021-01011-y"},{"key":"10.12890\/2024_004886_ref5","unstructured":"<li>Lewis RA, Howell JB. Definition of the hyperventilation syndrome. <em>Bull Eur Physiopathol Respir<\/em> 1986;<strong>22<\/strong>:201-205.<\/li>"},{"key":"10.12890\/2024_004886_ref6","doi-asserted-by":"crossref","unstructured":"<li>Boulding R, Stacey R, Niven R, Fowler SJ. Dysfunctional breathing: a review of the literature and proposal for classification. <em>Eur Respir Ver<\/em> 2016;<strong>25<\/strong>:287-94.<\/li>","DOI":"10.1183\/16000617.0088-2015"},{"key":"10.12890\/2024_004886_ref7","doi-asserted-by":"crossref","unstructured":"<li>Sadlon A, Chaitow L. Hyperventilation Syndrome\/Breathing Pattern Disorders. In: Pizzorno JE, Murray MT editors. (2020). Textbook of Natural Medicine (5th ed.), Elsevier Enhanced Digital Version; 2020, p. 999-1008.<\/li>","DOI":"10.1016\/B978-0-323-43044-9.00135-7"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/4886\/4301","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/4886\/4302","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/4886\/4302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T09:49:17Z","timestamp":1755596957000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/4886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,7]]},"references-count":7,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.12890\/2024_004886","relation":{"has-manifestation":[{"id-type":"other","id":"1-119-4886-g4301","asserted-by":"subject"},{"id-type":"other","id":"1-119-4886-g4302","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-119","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2024,10,7]]}}}