{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T17:48:38Z","timestamp":1755798518773,"version":"3.44.0"},"reference-count":8,"publisher":"SMC Media","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Background:\u00a0Beh\u00e7et\u2019s disease (BD) is a rare, multisystemic inflammatory disorder with a diverse range of manifestations, primarily affecting the mucocutaneous and ocular systems. While vascular involvement is less frequent it can be severe, with coronary aneurysms being particularly rare. Case description:\u00a0We report a 28-year-old male with BD who developed a giant anterior interventricular artery aneurysm. The patient, initially managed with azathioprine and colchicine, presented with acute chest pain and elevated cardiac markers. Imaging revealed a coronary aneurysm measuring 5.03 cm. Due to the inflammatory nature of the aneurysm surgical intervention was initially deferred, and the patient was treated with corticosteroids and cyclophosphamide. Despite these treatments, recurrent symptoms prompted the initiation of infliximab therapy. Administered at 5 mg\/kg at weeks 0, 2 and 6, with subsequent doses every two months, infliximab led to a significant reduction in aneurysm size to 3.73 cm. Conclusion:\u00a0This case highlights the effectiveness of infliximab in managing giant coronary aneurysms associated with BD, demonstrating its potential as a treatment option for severe vascular complications in BD. The substantial reduction in aneurysm size following infliximab therapy underscores the need for further investigation into its role in treating such rare but serious manifestations of BD.<\/jats:p>","DOI":"10.12890\/2024_004894","type":"journal-article","created":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T08:48:16Z","timestamp":1727858896000},"source":"Crossref","is-referenced-by-count":0,"title":["Infliximab in the treatment of a giant coronary aneurysm in Beh\u00e7et\u2019s disease"],"prefix":"10.12890","volume":"11","author":[{"given":"Salma","family":"Boustani","sequence":"first","affiliation":[{"name":"Internal Medicine Department, CHU SOUSS-Massa, Agadir, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abderrahmane","family":"Ibnyghig","sequence":"first","affiliation":[{"name":"Radiology Department, CHU SOUSS-Massa, Agadir, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soukaing","family":"Wakrim","sequence":"first","affiliation":[{"name":"Radiology Department, CHU SOUSS-Massa, Agadir, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wassila","family":"Bouissgr","sequence":"first","affiliation":[{"name":"Internal Medicine Department, CHU SOUSS-Massa, Agadir, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2024,10,2]]},"reference":[{"doi-asserted-by":"crossref","unstructured":"<li>Leccese P, Yazici Y, Olivieri I. Behcet\u2019s syndrome in nonendemic regions. <em>Curr Opin Rheumatol<\/em> 2017;<strong>29<\/strong>:12\u201316.<\/li>","key":"10.12890\/2024_004894_ref1","DOI":"10.1097\/BOR.0000000000000349"},{"doi-asserted-by":"crossref","unstructured":"<li>Sarica-Kucukoglu R, Akdag-Kose A, Kayabali M, Yazganoglu KD, Disci R, Erzengin D, et al. Vascular involvement in Beh\u00e7et\u2019s disease: a retrospective analysis of 2,319 cases. <em>Int J Dermatol<\/em> 2006;<strong>45<\/strong>:919\u2013921.<\/li>","key":"10.12890\/2024_004894_ref2","DOI":"10.1111\/j.1365-4632.2006.02832.x"},{"doi-asserted-by":"crossref","unstructured":"<li>Criteria for diagnosis of Behcet\u2019s disease. International Study Group for Behcet\u2019s Disease. <em>Lancet<\/em> 1990;<strong>335<\/strong>:1078\u20131080.<\/li>","key":"10.12890\/2024_004894_ref3","DOI":"10.1016\/0140-6736(90)92643-V"},{"doi-asserted-by":"crossref","unstructured":"<li>Schiff S, Moffatt R, Mandel WJ, Rubin SA. Acute myocardial infarction and recurrent ventricular arrhythmias in Beh\u00e7et\u2019s syndrome. <em>Am Heart J<\/em> 1982;<strong>103<\/strong>:438\u2013440.<\/li>","key":"10.12890\/2024_004894_ref4","DOI":"10.1016\/0002-8703(82)90289-7"},{"doi-asserted-by":"crossref","unstructured":"<li>Kariyanna, PT, Shah P, Jayarangaiah A, Chowdhury YS, Lazaro D. Acute coronary syndrome in Behcet\u2019s syndrome: a systematic review. <em>Eur J Rheumatol<\/em> 2021;<strong>8<\/strong>:31\u201335.<\/li>","key":"10.12890\/2024_004894_ref5","DOI":"10.5152\/eurjrheum.2020.19213"},{"unstructured":"<li>Wechsler B, Du LT, Kieffer E. Manifestations cardio-vasculaires de la maladie de Beh\u00e7et [Cardiovascular manifestations of Beh\u00e7et\u2019s disease]. <em>Ann Med Interne (Paris)<\/em> 1999;<strong>150<\/strong>:542\u2013554. French.<\/li>","key":"10.12890\/2024_004894_ref6"},{"doi-asserted-by":"crossref","unstructured":"<li>Meric M, Oztas DM, Ugurlucan M, Tireli E, Dayioglu E. Giant left anterior descending coronary artery aneurysm in a patient with Beh\u00e7et\u2019s disease. <em>Braz J Cardiovasc Surg<\/em> 2022;<strong>37<\/strong>:605\u2013608.<\/li>","key":"10.12890\/2024_004894_ref7","DOI":"10.21470\/1678-9741-2020-0665"},{"doi-asserted-by":"crossref","unstructured":"<li>Yoshimi R. The diagnosis and management of vasculo-Beh\u00e7et\u2019s disease. <em>Intern Med<\/em> 2019;<strong>58<\/strong>:3\u20134.<\/li>","key":"10.12890\/2024_004894_ref8","DOI":"10.2169\/internalmedicine.1657-18"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/4894\/4297","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/4894\/4298","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/4894\/4298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T09:49:21Z","timestamp":1755596961000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/4894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,2]]},"references-count":8,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.12890\/2024_004894","relation":{"has-manifestation":[{"id-type":"other","id":"1-119-4894-g4297","asserted-by":"subject"},{"id-type":"other","id":"1-119-4894-g4298","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-119","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2024,10,2]]}}}