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This case emphasizes the pathogenic kinetics of high ANCA titer in ulcerative colitis.<\/jats:p>","DOI":"10.12890\/2025_005061","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T10:53:08Z","timestamp":1746442388000},"source":"Crossref","is-referenced-by-count":0,"title":["Exploring ANCA Pathogenicity in Ulcerative Colitis: A Case Report Highlighting the Risk of Progression to ANCA-Associated Vasculitis"],"prefix":"10.12890","volume":"12","author":[{"given":"Abir","family":"Hamid","sequence":"first","affiliation":[{"name":"Internal Medicine Department, H\u00f4pital Erasme, H\u00f4pital Universitaire de Bruxelles (HUB), Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederic","family":"Vandergheynst","sequence":"first","affiliation":[{"name":"Internal Medicine Department, H\u00f4pital Erasme, H\u00f4pital Universitaire de Bruxelles (HUB), Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxime","family":"Ilzkovitz","sequence":"first","affiliation":[{"name":"Internal Medicine Department, H\u00f4pital Erasme, H\u00f4pital Universitaire de Bruxelles (HUB), Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2025,5,5]]},"reference":[{"key":"10.12890\/2025_005061_ref1","doi-asserted-by":"crossref","unstructured":"<li>Kitching AR, Anders HJ, Basu N, Brouwer E, Gordon J, Jayne DR, et al. ANCA-associated vasculitis. <em>Nat Rev Dis Primers<\/em> 2020;<strong>6<\/strong>:71. <\/li>","DOI":"10.1038\/s41572-020-0204-y"},{"key":"10.12890\/2025_005061_ref2","doi-asserted-by":"crossref","unstructured":"<li>Olson SW, Owshalimpur D, Yuan CM, Arbogast C, Baker TP, Oliver D, et al. Relation between Asymptomatic Proteinase 3 Antibodies and Future Granulomatosis with Polyangiitis. <em>Clin J Am Soc Nephrol<\/em> 2013;<strong>8<\/strong>:1312\u20131318. <\/li>","DOI":"10.2215\/CJN.10411012"},{"key":"10.12890\/2025_005061_ref3","doi-asserted-by":"crossref","unstructured":"<li>Bornstein G, Ben-Zvi I, Furie N, Grossman C. Clinical significance of positive anti-neutrophil cytoplasmic antibodies without evidence of anti-neutrophil cytoplasmic antibodies-associated vasculitis. <em>Int J Rheum Dis<\/em> 2019;<strong>22<\/strong>:940\u2013945. <\/li>","DOI":"10.1111\/1756-185X.13483"},{"key":"10.12890\/2025_005061_ref4","doi-asserted-by":"crossref","unstructured":"<li>Folci M, Ramponi G, Solitano V, Brunetta E. Serum ANCA as Disease Biomarkers: Clinical Implications Beyond Vasculitis. <em>Clin Rev Allergy Immunol<\/em> 2022;<strong>63<\/strong>:107\u2013123. <\/li>","DOI":"10.1007\/s12016-021-08887-w"},{"key":"10.12890\/2025_005061_ref5","doi-asserted-by":"crossref","unstructured":"<li>Prideaux L, De Cruz P, Ng SC, Kamm MA. Serological antibodies in inflammatory bowel disease: a systematic review. <em>Inflamm Bowel Dis<\/em> 2012;<strong>18<\/strong>:1340\u20131355. <\/li>","DOI":"10.1002\/ibd.21903"},{"key":"10.12890\/2025_005061_ref6","doi-asserted-by":"crossref","unstructured":"<li>Arias-Loste MT, Bonilla G, Moraleja I, Mahler M, Mieses MA, Castro B, et al. Presence of anti-proteinase 3 antineutrophil cytoplasmic antibodies (anti-PR3 ANCA) as serologic markers in inflammatory bowel disease. <em>Clin Rev Allergy Immunol<\/em> 2013;<strong>45<\/strong>:109\u2013116. <\/li>","DOI":"10.1007\/s12016-012-8349-4"},{"key":"10.12890\/2025_005061_ref7","doi-asserted-by":"crossref","unstructured":"<li>Imakiire S, Takedatsu H, Mitsuyama K, Sakisaka H, Tsuruta K, Morita M, et al. Role of Serum Proteinase 3 Antineutrophil Cytoplasmic Antibodies in the Diagnosis, Evaluation of Disease Severity, and Clinical Course of Ulcerative Colitis. <em>Gut Liver<\/em> 2022;<strong>16<\/strong>:92\u2013100. <\/li>","DOI":"10.5009\/gnl210211"},{"key":"10.12890\/2025_005061_ref8","doi-asserted-by":"crossref","unstructured":"<li>Humbert S, Guilpain P, Pu\u00e9chal X, Terrier B, Rivi\u00e8re S, Mahr A, et al. Inflammatory bowel diseases in anti-neutrophil cytoplasmic antibody-associated vasculitides: 11 retrospective cases from the French Vasculitis Study Group. <em>Rheumatology (Oxford)<\/em> 2015;<strong>54<\/strong>:1970-1975. <\/li>","DOI":"10.1093\/rheumatology\/kev199"},{"key":"10.12890\/2025_005061_ref9","doi-asserted-by":"crossref","unstructured":"<li>Mumtaz S, Valecha J, Hochwald A, Berianu F, Majithia V, Abril A. Investigating the concomitance of anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitides and inflammatory bowel disease (IBD). <em>Semin Arthritis Rheum<\/em> 2024;<strong>66<\/strong>:152452. <\/li>","DOI":"10.1016\/j.semarthrit.2024.152452"},{"key":"10.12890\/2025_005061_ref10","doi-asserted-by":"crossref","unstructured":"<li>Sy A, Khalidi N, Dehghan N, Barra L, Carette S, Cuthbertson D, et al. Vasculitis in patients with inflammatory bowel diseases: A study of 32 patients and systematic review of the literature. <em>Semin Arthritis Rheum<\/em> 2016;<strong>45<\/strong>:475\u2013482. <\/li>","DOI":"10.1016\/j.semarthrit.2015.07.006"},{"key":"10.12890\/2025_005061_ref11","doi-asserted-by":"crossref","unstructured":"<li>Long D, Mao C, Xu Y, Zhu Y. The emerging role of neutrophil extracellular traps in ulcerative colitis. <em>Front Immunol<\/em> 2024;<strong>15<\/strong>:1425251. <\/li>","DOI":"10.3389\/fimmu.2024.1425251"},{"key":"10.12890\/2025_005061_ref12","doi-asserted-by":"crossref","unstructured":"<li>Forrest JA, Shearman DJ. Pulmonary vasculitis and ulcerative colitis. <em>Am J Dig Dis<\/em> 1975;<strong>20<\/strong>:482\u2013486. <\/li>","DOI":"10.1007\/BF01070795"},{"key":"10.12890\/2025_005061_ref13","doi-asserted-by":"crossref","unstructured":"<li>dos Santos CE, Dal Pizzol VI, Aragao SC, Rachid Filho A, Marques FM. c-ANCA associated vasculitis in patients with ulcerative colitis: case report. <em>Rev Bras Reumatol<\/em> 2013;<strong>53<\/strong>:441\u2013443. <\/li>","DOI":"10.1016\/S2255-5021(13)70116-0"},{"key":"10.12890\/2025_005061_ref14","unstructured":"<li>Vesel HT, Eithz C. 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Severe diffuse alveolar hemorrhage related to autoimmune disease: a multicenter study. <em>Crit Care<\/em> 2020;<strong>24<\/strong>:231. <\/li>","DOI":"10.1186\/s13054-020-02936-0"},{"key":"10.12890\/2025_005061_ref18","doi-asserted-by":"crossref","unstructured":"<li>Aoyama Y, Inaba T, Takahashi S, Yasuhara H, Hiraoka S, Morimoto T, et al. Anti-proteinase 3 antineutrophil cytoplasmic antibody reflects disease activity and predicts the response to steroid therapy in ulcerative colitis. <em>BMC Gastroenterol<\/em> 2021;<strong>21<\/strong>:325. <\/li>","DOI":"10.1186\/s12876-021-01903-5"},{"key":"10.12890\/2025_005061_ref19","doi-asserted-by":"crossref","unstructured":"<li>Yoshida A, Matsuoka K, Ueno F, Morizane T, Endo Y, Hibi T. Serum PR3-ANCA Is a Predictor of Primary Nonresponse to Anti-TNF-alpha Agents in Patients with Ulcerative Colitis. <em>Inflamm Intest Dis<\/em> 2021;<strong>6<\/strong>:117\u2013122. <\/li>","DOI":"10.1159\/000515361"},{"key":"10.12890\/2025_005061_ref20","doi-asserted-by":"crossref","unstructured":"<li>Kemna MJ, Schlumberger W, van Paassen P, Dahnrich C, Damoiseaux JGMC, Cohen Tervaert JW. 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