{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:55:10Z","timestamp":1790369710747,"version":"4.1.0"},"reference-count":10,"publisher":"SMC Media","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Oesophageal dysmotility is a serious condition characterised by impaired coordination of oesophageal smooth muscle contractions, which can be secondary to a variety of causes including infection, inflammation and malignancy. The presenting symptoms are variable and include chest or epigastric pain, food regurgitation, heartburn or cough, making it difficult to distinguish. Diagnostic modalities and treatment strategies vary depending on the underlying cause. Once oesophageal dysmotility is suspected, a thorough evaluation is essential as the management strategies and prognosis of the condition differ significantly based on the underlying pathology. A multidisciplinary approach and clinical expertise are essential for optimal patient care and treatment. While neuromuscular disorders are associated with swallowing dysfunction due to oropharyngeal muscle involvement, oesophageal smooth muscles involvement is rare. This case highlights the importance of careful and frequent evaluation of both respiratory and gastrointestinal smooth muscle function, particularly in patients with chronic neurological disorders.<\/jats:p>","DOI":"10.12890\/2025_005219","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T12:28:12Z","timestamp":1742214492000},"source":"Crossref","is-referenced-by-count":1,"title":["Oesophageal dysmotility in a patient with Charcot-Marie-Tooth disease: report and literature review"],"prefix":"10.12890","volume":"12","author":[{"given":"Mohammad","family":"Kloub","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Saint Micheal\u2019s Medical Center, Newark, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul-Rahman I","family":"Abusalim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Hospital Medicine, University of Wisconsin School of Medicine and Public Health, Madison, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Eldesouki","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Saint Micheal\u2019s Medical Center, Newark, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Abushanab","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Saint Micheal\u2019s Medical Center, Newark, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byron","family":"Okwesili","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology and Hepatology, Saint Micheal\u2019s Medical Center, Newark, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raed","family":"Atiyat","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology and Hepatology, Saint Micheal\u2019s Medical Center, Newark, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yatinder","family":"Bains","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology and Hepatology, Saint Micheal\u2019s Medical Center, Newark, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10397","published-online":{"date-parts":[[2025,3,17]]},"reference":[{"key":"10.12890\/2025_005219_ref1","doi-asserted-by":"crossref","unstructured":"<li>Chan CK, Mohsenin V, Loke J, Virgulto J, Sipski ML, Ferranti, R. Diaphragmatic dysfunction in siblings with hereditary motor and sensory neuropathy (Charcot-Marie-Tooth disease). <em>Chest<\/em> 1987;<strong>91<\/strong>:567\u2013570. <\/li>","DOI":"10.1378\/chest.91.4.567"},{"key":"10.12890\/2025_005219_ref2","doi-asserted-by":"crossref","unstructured":"<li>Pareyson D, Marchesi C. Intro to CMT and subtypes associated with autonomic dysfunction and dysmotility. <em>The Lancet Neurology<\/em> 2009;<strong>8<\/strong>:654\u2013667. <\/li>","DOI":"10.1016\/S1474-4422(09)70110-3"},{"key":"10.12890\/2025_005219_ref3","doi-asserted-by":"crossref","unstructured":"<li>Jani-Acsadi A, Krajewski K, Shy ME. Charcot-Marie-Tooth neuropathies: diagnosis and management. <em>Semin Neurol<\/em> 2008;<strong>28<\/strong>:185\u2013194. <\/li>","DOI":"10.1055\/s-2008-1062264"},{"key":"10.12890\/2025_005219_ref4","doi-asserted-by":"crossref","unstructured":"<li>Stojkovic T, de Seze J, Dubourg O, Arne-Bes MC, Tardieu S, Hache JC, et al. Autonomic and respiratory dysfunction in Charcot-Marie-Tooth disease due to Thr124Met mutation in the myelin protein zero gene. <em>Clin Neurophysiol<\/em> 2003;<strong>114<\/strong>:1609\u20131614. <\/li>","DOI":"10.1016\/S1388-2457(03)00159-7"},{"key":"10.12890\/2025_005219_ref5","doi-asserted-by":"crossref","unstructured":"<li>Soykan I, McCallum RW. Gastrointestinal involvement in neurologic disorders: Stiff-man and Charcot-Marie-Tooth syndromes. <em>The American Journal of the Medical Sciences<\/em> 1997;<strong>313<\/strong>:70\u201373. <\/li>","DOI":"10.1097\/00000441-199701000-00012"},{"key":"10.12890\/2025_005219_ref6","doi-asserted-by":"crossref","unstructured":"<li>Spechler SJ. American Gastroenterological Association medical position statement on treatment of patients with dysphagia caused by benign disorders of the distal esophagus. <em>Gastroenterology<\/em> 1999;<strong>117<\/strong>:229\u2013232.<\/li>","DOI":"10.1016\/S0016-5085(99)70572-X"},{"key":"10.12890\/2025_005219_ref7","doi-asserted-by":"crossref","unstructured":"<li>Naniwadekar A, Mishra V, Sanjeevi A. Dysphagia in a patient with Charcot-Marie-Tooth disease: 544. <em>Am J Gastroenterol<\/em> 2009;<strong>104<\/strong>:S204. <\/li>","DOI":"10.14309\/00000434-200910003-00544"},{"key":"10.12890\/2025_005219_ref8","unstructured":"<li>Wilkinson JM, Halland M. 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Interchangeable use of proton pump inhibitors based on relative potency. <em>Clin Gastroenterol Hepatol<\/em> 2018;<strong>16<\/strong>:800\u2013808.e7. <\/li>","DOI":"10.1016\/j.cgh.2017.09.033"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/5219\/4531","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/5219\/4532","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/5219\/4532","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T09:38:15Z","timestamp":1755596295000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/5219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,17]]},"references-count":10,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.12890\/2025_005219","relation":{"has-manifestation":[{"id-type":"other","id":"1-124-5219-g4531","asserted-by":"subject"},{"id-type":"other","id":"1-124-5219-g4532","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-124","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"value":"2284-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,17]]}}}