{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T23:27:50Z","timestamp":1784330870654,"version":"3.55.0"},"reference-count":13,"publisher":"SMC Media","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Introduction:\u00a0Cystic fibrosis, an autosomal recessive disorder (1 in 3,000\u20136,000 births), causes thick mucus and recurrent lung infections. Improved survival has revealed rare complications such as constrictive pericarditis and cardiac tamponade. Case description:\u00a0A 24-year-old female with cystic fibrosis, diagnosed at nine months, presented with two weeks of dyspnoea. Examination revealed bilateral rhonchi, facial oedema and non-pitting thigh oedema. Laboratory results showed a white blood cell count of 11.3 \u00d7109\/l, erythrocyte sedimentation rate of 99 mm\/hr and C-reactive protein level of 45.3 mg\/dl. Initially admitted for cystic fibrosis exacerbation, she was found to have pericardial effusion. Despite facial and lower extremity swelling, she denied cardiac symptoms. During hospitalisation, she developed haemodynamic instability requiring pericardiocentesis, with echocardiography confirming constrictive pericarditis. Chest computed tomography angiography showed pericardial calcifications; autoimmune workup was negative. She was discharged on colchicine with close follow-up. Conclusion:\u00a0Clinicians should have a high index of suspicion for underlying cardiac complications in patients presenting with exacerbations of cystic fibrosis.<\/jats:p>","DOI":"10.12890\/2025_005373","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T09:29:21Z","timestamp":1747387761000},"source":"Crossref","is-referenced-by-count":1,"title":["Acute pericarditis in an adult with cystic fibrosis: a case report and literature review"],"prefix":"10.12890","volume":"12","author":[{"given":"Amer","family":"Abu-Shanab","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Rutgers-Monmouth Medical Center, Long Branch, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Tayyeb","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Rutgers-Monmouth Medical Center, Long Branch, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Saad Anwar","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Rutgers-Monmouth Medical Center, Long Branch, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Angelo Aquino","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Rutgers-Monmouth Medical Center, Long Branch, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Amog","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Rutgers-Monmouth Medical Center, Long Branch, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdalhakim","family":"Shubietah","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Advocate Illinois Masonic Medical Center, Chicago, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doantrang","family":"Du","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Rutgers-Monmouth Medical Center, Long Branch, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10397","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"key":"10.12890\/2025_005373_ref1","doi-asserted-by":"crossref","unstructured":"Scotet V, L'Hostis C, F\u00e9rec C. The changing epidemiology of cystic fibrosis: incidence, survival and impact of the CFTR Gene Discovery. Genes (Basel) 2020;11:589. doi: 10.3390\/genes11060589","DOI":"10.3390\/genes11060589"},{"key":"10.12890\/2025_005373_ref2","doi-asserted-by":"crossref","unstructured":"Gentzsch M, Mall MA. Ion channel modulators in cystic fibrosis. Chest 2018;154:383\u2013393. doi: 10.1016\/j.chest.2018.04.036","DOI":"10.1016\/j.chest.2018.04.036"},{"key":"10.12890\/2025_005373_ref3","doi-asserted-by":"crossref","unstructured":"Coutinho H, Falc\u00e3o-Silva VS, Gon\u00e7alves GF. Pulmonary bacterial pathogens in cystic fibrosis patients and antibiotic therapy: a tool for the health workers. Int Arch Med 2008;1:24. doi: 10.1186\/1755-7682-1-24","DOI":"10.1186\/1755-7682-1-24"},{"key":"10.12890\/2025_005373_ref4","doi-asserted-by":"crossref","unstructured":"Elborn JS. Cystic fibrosis. Lancet 2016;388:2519-2531. doi: 10.1016\/S0140-6736(16)00576-6","DOI":"10.1016\/S0140-6736(16)00576-6"},{"key":"10.12890\/2025_005373_ref5","unstructured":"Cystic Fibrosis Foundation. 2022 Patient Registry Annual Data Report. Bethesda, MD. Cystic Fibrosis Foundation; 2023. Available from: https:\/\/www.cff.org\/media\/29691\/download."},{"key":"10.12890\/2025_005373_ref6","doi-asserted-by":"crossref","unstructured":"Corriveau S, Sykes J, Stephenson AL. Cystic fibrosis survival: the changing epidemiology. Curr Opin Pulm Med 2018;24:574\u2013578. doi: 10.1097\/MCP.0000000000000520","DOI":"10.1097\/MCP.0000000000000520"},{"key":"10.12890\/2025_005373_ref7","doi-asserted-by":"crossref","unstructured":"Welch TD, Oh JK. Constrictive pericarditis. Cardiol Clin 2017;35:539\u2013549. doi: 10.1016\/j.ccl.2017.07.007","DOI":"10.1016\/j.ccl.2017.07.007"},{"key":"10.12890\/2025_005373_ref8","doi-asserted-by":"crossref","unstructured":"Brown MT, McDowell AC, Clements SD Jr, Dressler DD. Here\u2019s the rub: a case of constrictive pericarditis in an adult with cystic fibrosis. Respir Med Case Rep 2021;33:101434. doi: 10.1016\/j.rmcr.2021.101434","DOI":"10.1016\/j.rmcr.2021.101434"},{"key":"10.12890\/2025_005373_ref9","unstructured":"McCartney C, Nayak R. Idiopathic constrictive pericardial disease in a patient with cystic fibrosis. Am J Med Case Rep 2016;4:118\u2013121. doi: 10.12691\/ajmcr-4-4-2"},{"key":"10.12890\/2025_005373_ref10","doi-asserted-by":"crossref","unstructured":"Betancourt MF, Benninghoff MG, Vender RL, Grando Ting J. Cardiac tamponade from acute pericarditis associated with a cystic fibrosis (CF) lung infection. Respir Med CME 2010;3:156\u2013159. https:\/\/doi.org\/10.1016\/j.rmedc.2009.09.008","DOI":"10.1016\/j.rmedc.2009.09.008"},{"key":"10.12890\/2025_005373_ref11","doi-asserted-by":"crossref","unstructured":"O'Grady JG, Connaughton J, Finnegan P, McCarthy CF. Calcific pericarditis and cystic fibrosis in a 34 year old male. 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