{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T17:02:20Z","timestamp":1775667740954,"version":"3.50.1"},"reference-count":9,"publisher":"SMC Media","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Acute pancreatitis is an inflammatory condition of the pancreas that can result from various aetiologies, one of them being drug-induced pancreatitis, a relatively rare cause. Drug-induced pancreatitis should be considered in patients presenting with epigastric pain, elevated pancreatic enzymes, and imaging findings consistent with acute pancreatitis, in the absence of any common precipitants such as alcohol, gallstones, trauma. We report a case of acute pancreatitis following the initiation of baclofen therapy, with no other identifiable risk factors. A probable drug adverse reaction was established through the Naranjo Adverse Drug Reaction Probability Scale. This case highlights the need for physicians to consider baclofen as a potential cause of acute pancreatitis.<\/jats:p>","DOI":"10.12890\/2025_005393","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T04:57:26Z","timestamp":1744952246000},"source":"Crossref","is-referenced-by-count":2,"title":["Baclofen-induced pancreatitis"],"prefix":"10.12890","volume":"12","author":[{"given":"Nicolas","family":"Nassif","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Balamand, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Katrib","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Balamand, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karam","family":"Karam","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University of Balamand, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elias","family":"Fiani","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University of Balamand, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2025,4,18]]},"reference":[{"key":"10.12890\/2025_005393_ref1","doi-asserted-by":"crossref","unstructured":"<li>Bao YK, Ganesan VC, Jiang W, Lin L, Brown NR, Steigerwalt KE, et al. Muscle relaxant induced pancreatitis leading to hyperosmolar hyperglycemic state. <em>Oxf Med Case Reports<\/em> 2019;<strong>2019<\/strong>:omz012.<\/li>","DOI":"10.1093\/omcr\/omz012"},{"key":"10.12890\/2025_005393_ref2","doi-asserted-by":"crossref","unstructured":"<li>de Sousa N, Santos D, Monteiro S, Silva N, Barreiro-Iglesias A, Salgado AJ. Role of Baclofen in Modulating Spasticity and Neuroprotection in Spinal Cord Injury. <em>J Neurotrauma<\/em> 2022;39:249-258.<\/li>","DOI":"10.1089\/neu.2020.7591"},{"key":"10.12890\/2025_005393_ref3","unstructured":"<li>Jones MR, Hall OM, Kaye AM, Kaye AD. Drug-induced acute pancreatitis: a review. <em>Ochsner J<\/em> 2015;<strong>15<\/strong>:45-51.<\/li>"},{"key":"10.12890\/2025_005393_ref4","doi-asserted-by":"crossref","unstructured":"<li>Munsell MA, Buscaglia JM. Acute pancreatitis. <em>J Hosp Med<\/em> 2010;<strong>5<\/strong>:241-250.<\/li>","DOI":"10.1002\/jhm.574"},{"key":"10.12890\/2025_005393_ref5","doi-asserted-by":"crossref","unstructured":"<li>Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reactions. <em>Clin Pharmacol Ther<\/em> 1981;<strong>30<\/strong>:239-245.<\/li>","DOI":"10.1038\/clpt.1981.154"},{"key":"10.12890\/2025_005393_ref6","doi-asserted-by":"crossref","unstructured":"<li>Szatmary P, Grammatikopoulos T, Cai W, Huang W, Mukherjee R, Halloran C, et al. Acute Pancreatitis: Diagnosis and Treatment. <em>Drugs<\/em> 2022;<strong>82<\/strong>:1251-1276.<\/li>","DOI":"10.1007\/s40265-022-01766-4"},{"key":"10.12890\/2025_005393_ref7","doi-asserted-by":"crossref","unstructured":"<li>Trivedi CD, Pitchumoni CS. Drug-induced pancreatitis: an update. <em>J Clin Gastroenterol<\/em> 2005;<strong>39<\/strong>:709-716.<\/li>","DOI":"10.1097\/01.mcg.0000173929.60115.b4"},{"key":"10.12890\/2025_005393_ref8","doi-asserted-by":"crossref","unstructured":"<li>Warren RL, Davis SM. The Role of Baclofen in the Treatment of Gastroesophageal Reflux Disease. <em>J Pharm Technol<\/em> 2015;<strong>31<\/strong>:258-261.<\/li>","DOI":"10.1177\/8755122515586835"},{"key":"10.12890\/2025_005393_ref9","unstructured":"<li>Underwood TW, Frye CB. Drug-induced pancreatitis. <em>Clin Pharm<\/em> 1993;<strong>12<\/strong>:440-448.<\/li>"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/5393\/4598","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/5393\/4599","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/5393\/4599","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T09:32:51Z","timestamp":1755595971000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/5393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,18]]},"references-count":9,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.12890\/2025_005393","relation":{"has-manifestation":[{"id-type":"other","id":"1-125-5393-g4598","asserted-by":"subject"},{"id-type":"other","id":"1-125-5393-g4599","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-125","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"value":"2284-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,18]]}}}