{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T17:50:44Z","timestamp":1755798644396,"version":"3.44.0"},"reference-count":12,"publisher":"SMC Media","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Introduction:\u00a0Hypercalcaemia in intravascular large B-cell lymphoma (IVLBCL) is extremely rare, occurring more often in other non-Hodgkin\u2019s lymphomas (NHL). Case description:\u00a0A 68-year-old man was admitted with a fever of unknown origin, mild disturbance of consciousness and respiratory failure. Laboratory findings showed hypercalcaemia with elevated parathyroid hormone-related protein (PTHrP) and decreased intact parathyroid hormone and 1,25-dihydroxyvitamin D. The patient was diagnosed with IVLBCL via random skin biopsy. Chemotherapy resulted in complete remission and normalised PTHrP levels. Conclusion:\u00a0More than half of all cases of hypercalcaemia in NHL are not associated with PTHrP or 1,25-dihydroxyvitamin D, and the cause of the hypercalcaemia is unknown. However, PTHrP levels are elevated in most cases of IVLBCL with hypercalcaemia, which may present as humoral hypercalcaemia of malignancy.<\/jats:p>","DOI":"10.12890\/2025_005406","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T09:21:28Z","timestamp":1745400088000},"source":"Crossref","is-referenced-by-count":0,"title":["A case of intravascular large B-cell lymphoma complicated by hypercalcaemia"],"prefix":"10.12890","volume":"12","author":[{"given":"Masahiro","family":"Yabe","sequence":"first","affiliation":[{"name":"Department of General Internal Medicine, Niigata City General Hospital, Niigata, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Abe","sequence":"first","affiliation":[{"name":"Department of Hematology, Niigata City General Hospital, Niigata, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saori","family":"Yamaga","sequence":"first","affiliation":[{"name":"Department of General Internal Medicine, Niigata City General Hospital, Niigata, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiga","family":"Ozaki","sequence":"first","affiliation":[{"name":"Department of General Internal Medicine, Niigata City General Hospital, Niigata, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiro","family":"Tomiyama","sequence":"first","affiliation":[{"name":"Department of Dermatology, Niigata City General Hospital, Niigata, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Hashidate","sequence":"first","affiliation":[{"name":"Department of Pathology, Niigata City General Hospital, Niigata, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2025,4,23]]},"reference":[{"key":"10.12890\/2025_005406_ref1","doi-asserted-by":"crossref","unstructured":"<li>Guise TA, Wysolmerski JJ. 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