{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T16:59:41Z","timestamp":1757609981557,"version":"3.44.0"},"reference-count":8,"publisher":"SMC Media","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Background:\u00a0Although splenomegaly is a common finding in Epstein-Barr virus (EBV) infection, splenic infarction is rarely reported and may be under-recognised, especially in adults. Neurological complications such as aseptic meningitis are also uncommon but documented. The simultaneous occurrence of both complications in the context of primary EBV infection is exceptional. Case description:\u00a0We describe the case of a 56-year-old previously healthy man who presented with fever and abdominal pain. Abdominal computed tomography (CT) revealed splenomegaly and multiple wedge-shaped splenic infarcts. During admission, the patient developed transient disorientation, and cerebrospinal fluid analysis was consistent with aseptic meningitis. Serological and molecular testing confirmed acute EBV infection in blood, pharyngeal swab and cerebrospinal fluid. No underlying prothrombotic condition was identified. The patient recovered completely with supportive care, without the need for antiviral treatment or anticoagulation. Conclusions:\u00a0Splenic infarction is a rare but possibly underestimated complication of primary EBV infection, particularly in adults. Awareness of this association can help avoid unnecessary investigations or treatments. In selected patients, conservative management without anticoagulation may be appropriate.<\/jats:p>","DOI":"10.12890\/2025_005497","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T11:05:02Z","timestamp":1756724702000},"source":"Crossref","is-referenced-by-count":0,"title":["Splenic infarctions in acute Epstein-Barr virus infection: a rare but possibly underdiagnosed complication in adults"],"prefix":"10.12890","volume":"12","author":[{"given":"Carlos","family":"Tarrazo","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Hospital Universitario San Agust\u00edn, Asturias, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alba","family":"Barrag\u00e1n Mateos","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Hospital Universitario San Agust\u00edn, Asturias, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2025,9,1]]},"reference":[{"key":"10.12890\/2025_005497_ref1","doi-asserted-by":"crossref","unstructured":"Mamo G, Erickson S, Komanduri K, Zayas D, Aggarwal N. Infectious mononucleosis-induced splenic infarction: perhaps more common in healthy individuals than previously thought. Cureus 2023;15:e39472. doi: 10.7759\/cureus.39472","DOI":"10.7759\/cureus.39472"},{"key":"10.12890\/2025_005497_ref2","doi-asserted-by":"crossref","unstructured":"Kobayashi K, Kishi Y, Serizawa Y, Kimizuka Y, Ueno H. Splenic infarction associated with Epstein-Barr virus in an adult with an anatomic anomaly: a case report. Cureus 2023;15:e40530. doi: 10.7759\/cureus.40530","DOI":"10.7759\/cureus.40530"},{"key":"10.12890\/2025_005497_ref3","doi-asserted-by":"crossref","unstructured":"Batista M, Silva C, Gon\u00e7alves FMF, Machado M, Freitas S, Silva J, et al. Splenic infarction: a rare complication of infectious mononucleosis. Cureus 2023;15:e37414. doi: 10.7759\/cureus.37414","DOI":"10.7759\/cureus.37414"},{"key":"10.12890\/2025_005497_ref4","doi-asserted-by":"crossref","unstructured":"Ma Z, Wang Z, Zhang X, Yu H. Splenic infarction after Epstein\u2013Barr virus infection in a patient with hereditary spherocytosis: a case report and literature review. BMC Surg 2022;22:136. doi: 10.1186\/s12893-022-01580-5","DOI":"10.1186\/s12893-022-01580-5"},{"key":"10.12890\/2025_005497_ref5","doi-asserted-by":"crossref","unstructured":"Kalfoutzou A, Dimitrakoudi M, Mylonakis A, Kanellis T, Mostratou E. Splenic infarcts in an adult male with EBV infection: a rare complication. Oman Med J 2025;1-5. doi: 10.5001\/omj.2025.27","DOI":"10.5001\/omj.2025.27"},{"key":"10.12890\/2025_005497_ref6","doi-asserted-by":"crossref","unstructured":"Hakoshima M, Kitakaze K, Adachi H, Katsuyama H, Yanai H. Clinical, hematological, biochemical and radiological characteristics for patients with splenic infarction: case series with literature review. J Clin Med Res 2023;15:38\u201350. doi: 10.14740\/jocmr4836","DOI":"10.14740\/jocmr4836"},{"key":"10.12890\/2025_005497_ref7","doi-asserted-by":"crossref","unstructured":"Machado C, Melo Salgado J, Monjardino L. The unexpected finding of a splenic infarction in a patient with infectious mononucleosis due to Epstein-Barr virus. BMJ Case Rep 2015;2015:bcr2015212428. doi: 10.1136\/bcr-2015-212428","DOI":"10.1136\/bcr-2015-212428"},{"key":"10.12890\/2025_005497_ref8","doi-asserted-by":"crossref","unstructured":"Tselis A, Duman R, Storch GA, Lisak RP. Epstein-Barr virus encephalomyelitis diagnosed by polymerase chain reaction: detection of the genome in the CSF. Neurology 1997;48:1351-1355. doi: 10.1212\/wnl.48.5.1351","DOI":"10.1212\/WNL.48.5.1351"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/5497\/4824","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/5497\/4825","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/5497\/4825","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T12:43:28Z","timestamp":1756903408000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/5497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,1]]},"references-count":8,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.12890\/2025_005497","relation":{"has-manifestation":[{"id-type":"other","id":"1-129-5497-g4824","asserted-by":"subject"},{"id-type":"other","id":"1-129-5497-g4825","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-129","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2025,9,1]]}}}