{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T17:22:02Z","timestamp":1755796922283,"version":"3.44.0"},"reference-count":5,"publisher":"SMC Media","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Thyroid storm is observed in patients with untreated Graves\u2019 disease, typically triggered by stressors such as acute illness or recent surgery. This case presents a female with acute metabolic encephalopathy initially attributed to drug overdose and septic shock, later diagnosed with thyroid storm. Despite clinical stabilisation, the patient developed resistant hypertension and elevated metanephrine levels, raising suspicion for phaeochromocytoma and potential multiple endocrine neoplasia (MEN) 2A. This case highlights the importance of considering syndromic and autoimmune associations in complex endocrine presentations.<\/jats:p>","DOI":"10.12890\/2025_005559","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T08:50:57Z","timestamp":1752483057000},"source":"Crossref","is-referenced-by-count":0,"title":["Thyroid storm in the shadows of multiple endocrine neoplasia (MEN) 2A: a case of overlapping endocrine emergencies"],"prefix":"10.12890","volume":"12","author":[{"given":"Ridda","family":"Khattak","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Bayhealth Medical Center, Dover, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Cortez","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Bayhealth Medical Center, Dover, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madihah","family":"Alam","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Bayhealth Medical Center, Dover, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohab","family":"Sohail","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Bayhealth Medical Center, Dover, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaraq","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Indiana University School of Medicine Southwest, New Albany, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Azhar","sequence":"first","affiliation":[{"name":"Department of Pulmonology and Critical Care, Bayhealth Medical Center, Dover, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"doi-asserted-by":"crossref","unstructured":"Ono Y, Ono S, Yasunaga H, Matsui H, Fushimi K, Tanaka Y. Factors associated with mortality of thyroid storm: analysis using a national inpatient database in Japan. Medicine (Baltimore) 2016;95:e2848. doi:10.1097\/MD.0000000000002848","key":"10.12890\/2025_005559_ref1","DOI":"10.1097\/MD.0000000000002848"},{"doi-asserted-by":"crossref","unstructured":"Pandey R, Kumar S, Kotwal N. Thyroid storm: clinical manifestation, pathophysiology, and treatment. In: Agrawal NK, editor. Goiter: Causes and Treatment. London: IntechOpen; 2019. doi:10.5772\/intechopen.89620","key":"10.12890\/2025_005559_ref2","DOI":"10.5772\/intechopen.89620"},{"doi-asserted-by":"crossref","unstructured":"Idrose AM. Acute and emergency care for thyrotoxicosis and thyroid storm. Acute Med Surg 2015;2:147\u2013157. doi:10.1002\/ams2.104","key":"10.12890\/2025_005559_ref3","DOI":"10.1002\/ams2.104"},{"doi-asserted-by":"crossref","unstructured":"Akamizu T, Satoh T, Isozaki O, Suzuki A, Wakino S, Iburi T, et al. Diagnostic criteria, clinical features, and incidence of thyroid storm based on nationwide surveys. Thyroid 2012;22:661-679. doi: 10.1089\/thy.2011.0334","key":"10.12890\/2025_005559_ref4","DOI":"10.1089\/thy.2011.0334"},{"doi-asserted-by":"crossref","unstructured":"Manso J, Censi S, Iacobone M, Galuppini F, Pennelli G, Betterle C, et al. First proof of association between autoimmune polyglandular syndrome and multiple endocrine neoplasia in humans. Endocr J 2020;67:929\u2013934. doi:10.1507\/endocrj.EJ20-0099","key":"10.12890\/2025_005559_ref5","DOI":"10.1507\/endocrj.EJ20-0099"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/5559\/4748","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/5559\/4749","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/5559\/4749","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T10:10:17Z","timestamp":1755511817000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/5559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,14]]},"references-count":5,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.12890\/2025_005559","relation":{"has-manifestation":[{"id-type":"other","id":"1-128-5559-g4748","asserted-by":"subject"},{"id-type":"other","id":"1-128-5559-g4749","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-128","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2025,7,14]]}}}