{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T14:10:52Z","timestamp":1762524652062,"version":"build-2065373602"},"reference-count":6,"publisher":"SMC Media","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Background:\u00a0West Nile virus (WNV) is a mosquito-borne flavivirus that can cause neuroinvasive disease. Renal involvement is uncommon and acquired Fanconi syndrome has not been previously described in association with WNV. Case presentation:\u00a0An 81-year-old male from Cyprus presented with fever, headache, disorientation, and signs of meningoencephalitis. Cerebrospinal fluid (CSF) analysis and neuroimaging supported the diagnosis of viral encephalitis. Extensive microbiological testing revealed WNV ribonucleic acid in urine and blood, but not in the CSF. The patient developed persistent hypokalaemia, metabolic acidosis, hypomagnesemia, and hypouricemia, with elevated fractional excretion of these solutes\u2014findings consistent with Fanconi syndrome. Acyclovir was discontinued, and supportive treatment was provided. Renal function and electrolyte levels normalized by day 9. At 2-month follow-up, the patient had fully recovered with normal renal parameters. Conclusion:\u00a0Renal complications of WNV are rarely documented and this case of WNV associated acquired Fanconi syndrome underscores the importance of evaluating kidney function and electrolyte status in WNV-infected patients. Early recognition of tubular dysfunction may prevent complications and improve outcomes.<\/jats:p>","DOI":"10.12890\/2025_005787","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T08:55:04Z","timestamp":1761209704000},"source":"Crossref","is-referenced-by-count":0,"title":["West Nile virus neuroinvasive disease presenting with acquired Fanconi syndrome, which resolved on recovery"],"prefix":"10.12890","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9374-5746","authenticated-orcid":false,"given":"Paraskevi","family":"Karamani","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Apollonion Private Hospital, Nicosia, Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgos","family":"Souroullas","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Apollonion Private Hospital, Nicosia, Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amare","family":"Negash","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Apollonion Private Hospital, Nicosia, Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Tavos","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Apollonion Private Hospital, Nicosia, Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Miltiadous","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Apollonion Private Hospital, Nicosia, Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3958-2266","authenticated-orcid":false,"given":"Haralampos","family":"Milionis","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"key":"10.12890\/2025_005787_ref1","doi-asserted-by":"crossref","unstructured":"Barzon L, Pacenti M, Franchin E, Squarzon L, Sinigaglia A, Ulbert S, Cusinato R, Pal\u00f9 G. Isolation of West Nile virus from urine samples of patients with acute infection. J Clin Microbiol 2014;52:3411-3413. doi: 10.1128\/JCM.01328-14","DOI":"10.1128\/JCM.01328-14"},{"key":"10.12890\/2025_005787_ref2","doi-asserted-by":"crossref","unstructured":"Barzon L, Pacenti M, Pal\u00f9 G. West Nile virus and kidney disease. Expert Rev Anti Infect Ther 2013;11:479-487. doi: 10.1586\/eri.13.34. doi: 10.1586\/eri.13.34","DOI":"10.1586\/eri.13.34"},{"key":"10.12890\/2025_005787_ref3","doi-asserted-by":"crossref","unstructured":"Brener ZZ, Harbord NB, Zhuravenko I, Nicastri AD, Bergman M, Dubrow A, et al. Acute renal failure in a patient with West Nile viral encephalitis. Nephrol Dial Transplant 2007;22:662-663. doi: 10.1093\/ndt\/gfl599","DOI":"10.1093\/ndt\/gfl599"},{"key":"10.12890\/2025_005787_ref4","unstructured":"Vachvanichsanong P, McNeil E. ELECTROLYTE DISTURBANCE AND KIDNEY DYSFUNCTION IN DENGUE VIRAL INFECTION. Southeast Asian J Trop Med Public Health 2015;46:108-117."},{"key":"10.12890\/2025_005787_ref5","doi-asserted-by":"crossref","unstructured":"Burdmann EA, Jha V. Acute kidney injury due to tropical infectious diseases and animal venoms: a tale of 2 continents. Kidney Int 2017;91:1033-1046. doi: 10.1016\/j.kint.2016.09.051","DOI":"10.1016\/j.kint.2016.09.051"},{"key":"10.12890\/2025_005787_ref6","doi-asserted-by":"crossref","unstructured":"Kormann R, Jacquot A, Alla A, Corbel A, Koszutski M, Voirin P, et al. Coronavirus disease 2019: acute Fanconi syndrome precedes acute kidney injury. Clin Kidney J 2020;13:362-370. doi: 10.1093\/ckj\/sfaa109","DOI":"10.1093\/ckj\/sfaa109"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/5787\/4917","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/5787\/4918","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/5787\/4918","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T14:04:59Z","timestamp":1762524299000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/5787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,22]]},"references-count":6,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.12890\/2025_005787","relation":{"has-manifestation":[{"id-type":"other","id":"1-131-5787-g4917","asserted-by":"subject"},{"id-type":"other","id":"1-131-5787-g4918","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-131","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2025,10,22]]}}}