{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T15:19:55Z","timestamp":1775834395985,"version":"3.50.1"},"reference-count":7,"publisher":"SMC Media","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Introduction:\u00a0Sertraline is a widely prescribed selective serotonin reuptake inhibitor (SSRI) with a favourable safety profile, though rare adverse effects may occur. Case description:\u00a0We report the case of a 73-year-old woman with generalised anxiety disorder and panic disorder who developed new-onset urinary incontinence after initiation of sertraline. Symptoms improved with dose reduction but recurred at higher doses, suggesting a causal relationship. Management with clomipramine and solifenacin successfully resolved the urinary incontinence while maintaining psychiatric remission. Discussion:\u00a0Our case contributes to the limited literature by documenting an elderly female patient who developed urinary incontinence secondary to sertraline, confirmed through a temporal association, dose-\u2013response relationship, and symptom resolution with targeted interventions. Conclusion:\u00a0This case highlights the importance of recognising uncommon SSRI side effects and tailoring management to balance efficacy and tolerability.<\/jats:p>","DOI":"10.12890\/2025_005846","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T08:55:04Z","timestamp":1761209704000},"source":"Crossref","is-referenced-by-count":1,"title":["Sertraline-induced urinary incontinence"],"prefix":"10.12890","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8265-757X","authenticated-orcid":false,"given":"Abdulaziz Muflih","family":"Abudasser","sequence":"first","affiliation":[{"name":"Department of Medicine, College of Medicine, King Khalid University, Abha, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"key":"10.12890\/2025_005846_ref1","doi-asserted-by":"crossref","unstructured":"Cipriani A, La Ferla T, Furukawa TA, Signoretti A, Nakagawa A, Churchill R, et al. Sertraline versus other antidepressive agents for depression. Cochrane Database Syst Rev 2009;15:CD006117. doi: 10.1002\/14651858.CD006117.pub2. Update in: Cochrane Database Syst Rev 2010;(1):CD006117. doi: 10.1002\/14651858.CD006117","DOI":"10.1002\/14651858.CD006117"},{"key":"10.12890\/2025_005846_ref2","doi-asserted-by":"crossref","unstructured":"Pease E, Singh B, Ziegelmann M, Betcher H. Dose-dependent urinary incontinence with sertraline use in obsessive-compulsive disorder. Psychopharmacol Bull 2021;51:117\u2013121.","DOI":"10.64719\/pb.4422"},{"key":"10.12890\/2025_005846_ref3","doi-asserted-by":"crossref","unstructured":"Phiphopthatsanee N. Sertraline-induced urinary incontinence in adolescent: a case report. BJPsych Open 2023;9:S127. doi: 10.1192\/bjo.2023.356","DOI":"10.1192\/bjo.2023.356"},{"key":"10.12890\/2025_005846_ref4","doi-asserted-by":"crossref","unstructured":"\u00d6zdemir PG, Aydin A, G\u00fcle\u00e7 M, Aky\u00fcz \u00c7im EF. Switching to fluoxetine in a case of sertraline-induced urinary incontinence: a case report. Dusunen Adam J Psychiatr Neurol Sci 2013;26:117\u2013118. doi: 10.5350\/DAJPN2013260116","DOI":"10.5350\/DAJPN2013260116"},{"key":"10.12890\/2025_005846_ref5","doi-asserted-by":"crossref","unstructured":"Gormus ZIS, Vidin T, Koca RO, Solak H, Uslu EF. The effects of agomelatine, fluoxetine, and sertraline on rat bladder contraction in vitro. Dusunen Adam J Psychiatr Neurol Sci 2023;36:148\u2013156. doi: 10.14744\/DAJPNS.2023.00218","DOI":"10.14744\/DAJPNS.2023.00218"},{"key":"10.12890\/2025_005846_ref6","doi-asserted-by":"crossref","unstructured":"Uno J, Obara K, Suzuki H, Miyatani S, Chino D, Yoshio T, et al. Inhibitory effects of antidepressants on acetylcholine-induced contractions in isolated Guinea pig urinary bladder smooth muscle. 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