{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T18:39:43Z","timestamp":1767983983817,"version":"3.49.0"},"reference-count":10,"publisher":"SMC Media","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Background:\u00a0Ectopic liver (EL) is a rare developmental anomaly defined as hepatic tissue located outside the native liver without vascular or biliary continuity. It is most commonly reported in the gallbladder but has also been described in other intra-abdominal and extra-abdominal sites. The gastric location is exceptionally rare, with only a handful of cases reported in the literature. Case presentation:\u00a0We present the case of a 49-year-old previously healthy male with a 2-month history of dyspepsia and heartburn who underwent diagnostic gastroscopy. This latter showed a 15 mm antral submucosal lesion with central umbilication. Endoscopic ultrasound (EUS) of the lesion showed a well-defined, hypoechoic, heterogeneous 14.2 \u00d7 8 \u00d7 10.4 mm mass involving the mucosa, muscularis mucosa, and submucosa. EUS-guided fine needle biopsy using a 22 G needle yielded adequate tissue. Histopathological examination demonstrated normal hepatocyte plates with one-cell thickness, highlighted by reticulin staining. Special stains, including Perl\u2019s iron, periodic acid Schiff (PAS), and PAS with diastase, showed no abnormal inclusions or hemosiderin deposits, and no pancreatic or ductal structures were identified. These findings were diagnostic of ectopic liver tissue. The lesion showed no evidence of malignancy. Discussion:\u00a0EL is usually detected incidentally during surgery or autopsy, and preoperative diagnosis is challenging due to its small size, asymptomatic course, and unfamiliarity among clinicians. Gastric EL is exceedingly rare, with only 3 cases previously described in the pylorus or fundus. Our case is unique as it represents the first reported antral location and was diagnosed preoperatively with EUS-guided biopsy. Conclusion:\u00a0Although rare, EL should be considered in the differential diagnosis of gastric submucosal lesions. Histological confirmation is essential to exclude malignant transformation.<\/jats:p>","DOI":"10.12890\/2025_005989","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T15:17:22Z","timestamp":1766157442000},"source":"Crossref","is-referenced-by-count":0,"title":["Intragastric ectopic liver"],"prefix":"10.12890","volume":"13","author":[{"given":"Jessy","family":"Fadel","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, St George University of Beirut, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Attieh","sequence":"first","affiliation":[{"name":"Department of General surgery, University of Balamand, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karam","family":"Karam","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University of Balamand, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Rassam","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, St George University of Beirut, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zarouhie","family":"Meguerian","sequence":"first","affiliation":[{"name":"Department of Pathology, St George University of Beirut, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elias","family":"Fiani","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, St George University of Beirut, Beirut, Lebanon; Department of Gastroenterology and Hepatology, University of Balamand, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ihab I.","family":"El Hajj","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"10.12890\/2025_005989_ref1","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez Ruiz Y, Cotaina Gracia L, Ruiz De Temi\u00f1o M, Gonz\u00e1lez Esgueda AJ, Delgado Alvira MR. Review of published cases of hepatic choristoma. Differential diagnosis of umbilical cord masses. An Pediatr (Barc) 2015;83:132\u2013134. doi: 10.1016\/j.anpede.2015.07.005","DOI":"10.1016\/j.anpede.2015.07.005"},{"key":"10.12890\/2025_005989_ref2","unstructured":"Huang W, Xu X, Li T, Zhang H, Chen Y, Li S. Ectopic liver tissue in stomach paries: a case report. Int J Clin Exp Pathol 2015;8:11704\u201311707."},{"key":"10.12890\/2025_005989_ref3","doi-asserted-by":"crossref","unstructured":"Vormittag-Nocito E, Emmadi R. Ectopic liver tissue in the fundus of the stomach: A case report. J Mod Hum Pathol 2018;3:15\u201317. doi: 10.14312\/2397-6845.2018-5","DOI":"10.14312\/2397-6845.2018-5"},{"key":"10.12890\/2025_005989_ref4","doi-asserted-by":"crossref","unstructured":"Liu Q, Li J, Pan Y, Zheng X, Gao B. Challenge in Diagnosis and Treatment of Ectopic Hepatocellular Carcinoma: A Case Report and Literature Review. Front Surg 2022;9:827006. doi: 10.3389\/fsurg.2022.827006","DOI":"10.3389\/fsurg.2022.827006"},{"key":"10.12890\/2025_005989_ref5","doi-asserted-by":"crossref","unstructured":"Arora GS, Kalra S. Ectopic Liver Tissue Encountered Incidentally During a Laparoscopic Cholecystectomy: A Case Report. Cureus 2023;15:e42220. doi: 10.7759\/cureus.42220","DOI":"10.7759\/cureus.42220"},{"key":"10.12890\/2025_005989_ref6","doi-asserted-by":"crossref","unstructured":"Termos S, AlDuwaisan A, Alali M, Faour H, AlHomoud H, Alsaleh A. Gallbladder-associated symptomatic hepatic choristoma: Should you resect? Int J Surg Case Rep 2017;41:243-246. doi: 10.1016\/j.ijscr.2017.10.044","DOI":"10.1016\/j.ijscr.2017.10.044"},{"key":"10.12890\/2025_005989_ref7","doi-asserted-by":"crossref","unstructured":"Hussein Al-Janabi M, Kenaan NI, Sulaiman SH, Ibrahim JA, Saoud NAA, Kannan S, et al. Ectopic liver tissue adherent to the gallbladder serosa: two cases report from Syria. 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