{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:55:15Z","timestamp":1787169315684,"version":"build-2736575974"},"reference-count":10,"publisher":"SMC Media","issue":"2","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Background:\u00a0Pulmonary involvement is a significant aspect of many autoimmune diseases. Different pulmonary manifestations of autoimmune diseases encompass a variety of conditions that impact the lungs, including interstitial lung disease, cystic lung disease, pulmonary hypertension, and pleural involvement. One rare manifestation is light-chain deposition disease. Our case report aims to highlight the condition\u2019s rarity and presentation variability. Case presentation:\u00a0A 55-year-old Caucasian female with a history of Sj\u00f6gren\u2019s syndrome, papillary thyroid carcinoma status post thyroidectomy, and chronic leukopenia underwent a computed tomography (CT) of the chest for routine oncological surveillance. Imaging revealed an 8 mm left upper lobe nodule with bilateral bullous lung changes. A positron emission tomography\/CT showed mildly\u00a018F-fluorodeoxyglucose-avid pulmonary nodules with large pneumatoceles, but no evidence of metastatic disease, which increased in size over the next two years, increasing the concern for progressive lung disease. Subsequently, a lung biopsy revealed monotypic kappa light-chain deposition with plasma cell infiltration, establishing the diagnosis of light-chain deposition disease. Despite the radiographic progression, the patient remained asymptomatic and stable. She was managed conservatively with serial paraproteinemia and image-based monitoring. Conclusion:\u00a0Pulmonary light chain deposition disease is an infrequent condition requiring a high index of suspicion for diagnosis. Imaging findings can help identify it, but biopsy remains the definitive diagnostic tool. Due to the lack of established management guidelines, treatment is personalized based on disease extent and organ involvement. Further research is needed to understand better this rare entity\u2019s prognosis and optimal treatment approaches.<\/jats:p>","DOI":"10.12890\/2026_006086","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T13:54:52Z","timestamp":1769435692000},"source":"Crossref","is-referenced-by-count":1,"title":["Isolated pulmonary light chain deposition disease"],"prefix":"10.12890","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7267-8317","authenticated-orcid":false,"given":"Manogna","family":"Pendyala","sequence":"first","affiliation":[{"name":"Internal Medicine, St Vincent Medical Center, Toledo, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranathi","family":"Bandarupalli","sequence":"first","affiliation":[{"name":"Internal Medicine, St Vincent Medical Center, Toledo, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purnoor","family":"Kaur","sequence":"first","affiliation":[{"name":"Internal Medicine, St Vincent Medical Center, Toledo, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Khatri","sequence":"first","affiliation":[{"name":"Pulmonary and Critical Care Medicine, St. Vincent Medical Center, Toledo, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna","family":"Khatri","sequence":"first","affiliation":[{"name":"Internal medicine, BJ Medical College, Ahmedabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10397","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"10.12890\/2026_006086_ref1","doi-asserted-by":"crossref","unstructured":"Gupta N, Vassallo R, Wikenheiser-Brokamp KA, McCormack FX. 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Br J Med Med Res 2016;14:1\u20137. doi: 10.9734\/BJMMR\/2016\/25188","DOI":"10.9734\/BJMMR\/2016\/25188"},{"key":"10.12890\/2026_006086_ref8","doi-asserted-by":"crossref","unstructured":"Colombat M, Mal H, Copie-Bergman C, Diebold J, Damotte D, Callard P, et al. Primary cystic lung light chain deposition disease: a clinicopathologic entity derived from unmutated B cells with a stereotyped IGHV4-34\/IGKV1 receptor. Blood 2008;112:2004-2012. doi: 10.1182\/blood-2007-11-123596","DOI":"10.1182\/blood-2007-11-123596"},{"key":"10.12890\/2026_006086_ref9","doi-asserted-by":"crossref","unstructured":"Sheard S, Nicholson AG, Edmunds L, Wotherspoon AC, Hansell DM. Pulmonary light-chain deposition disease: CT and pathology findings in nine patients. Clin Radiol 2015;70:515-522. doi: 10.1016\/j.crad.2015.01.002","DOI":"10.1016\/j.crad.2015.01.002"},{"key":"10.12890\/2026_006086_ref10","doi-asserted-by":"crossref","unstructured":"Gonzalez TV, Roden AC, Bartholmai BJ, Lindell RM. 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