{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T13:19:31Z","timestamp":1778159971281,"version":"3.51.4"},"reference-count":10,"publisher":"SMC Media","issue":"5","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Cardiac involvement as the first manifestation of peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) is extremely rare. We report on a 72-year-old man with hypertension, dyslipidaemia and prediabetes who presented with acute pleuropericarditis, pericardial effusion and conduction abnormalities. Despite initial treatment, his condition worsened. Imaging revealed pericardial\/myocardial infiltration and a right atrial mass. Biopsy confirmed PTCL-NOS (CD3+, CD5+, CD7+, high Ki-67). Complications included ileus, pulmonary embolism and neutropaenia. CHOP failed; GemOx was ineffective; he died from hypernatremia. This reported case emphasises the aggressive course, diagnostic challenges and poor treatment response of cardiac PTCL-NOS.<\/jats:p>","DOI":"10.12890\/2026_006099","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T08:50:17Z","timestamp":1777279817000},"source":"Crossref","is-referenced-by-count":0,"title":["Cardiac involvement as first manifestation of peripheral T-cell not otherwise specified lymphoma"],"prefix":"10.12890","volume":"13","author":[{"given":"Paula","family":"Awamleh Garc\u00eda","sequence":"first","affiliation":[{"name":"Cardiology Department, Hospital Universitario de Getafe, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel Emilio","family":"Mongui\u00f3 Sant\u00edn","sequence":"first","affiliation":[{"name":"Cardiac Surgery Department, Hospital Universitario de la Princesa, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"L\u00f3pez Mart\u00ednez","sequence":"first","affiliation":[{"name":"Pathology Department, Hospital Universitario de la Princesa, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Hern\u00e1ndez Mu\u00f1iz","sequence":"first","affiliation":[{"name":"Radiology Department, Hospital Universitario de la Princesa, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"de la Serna Real de As\u00faa","sequence":"first","affiliation":[{"name":"Cardiology Department, Hospital Universitario de Getafe, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosal\u00eda","family":"Alonso Trillo","sequence":"first","affiliation":[{"name":"Haematology and Haemotherapy Department, Hospital Universitario de Getafe, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Isabel","family":"Delgado Trillo","sequence":"first","affiliation":[{"name":"Haematology and Haemotherapy Department, Hospital Universitario de Getafe, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10397","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"10.12890\/2026_006099_ref1","doi-asserted-by":"crossref","unstructured":"Basso C, Rizzo S, Valente M, Thiene G. Cardiac masses and tumours. Heart 2016;102:1230\u20131245. doi: 10.1136\/heartjnl-2014-306364","DOI":"10.1136\/heartjnl-2014-306364"},{"key":"10.12890\/2026_006099_ref2","doi-asserted-by":"crossref","unstructured":"Alaggio R, Amador C, Anagnostopoulos I, Attygalle AD, Araujo IBO, Berti E. et al. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms. Leukemia 2022;36:1720\u20131748. doi: 10.1038\/s41375-022-01620-2","DOI":"10.1038\/s41375-022-01620-2"},{"key":"10.12890\/2026_006099_ref3","doi-asserted-by":"crossref","unstructured":"Weisenburger DD, Savage KJ, Harris NL, Gascoyne RD, Jaffe ES, MacLennan KA, et al. International Peripheral T-cell Lymphoma Project. Peripheral T-cell lymphoma, not otherwise specified: a report of 340 cases from the International Peripheral T-cell Lymphoma Project. 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Br J Haematol 2017;176:851\u2013866. doi: 10.1111\/bjh.14473","DOI":"10.1111\/bjh.14473"},{"key":"10.12890\/2026_006099_ref7","doi-asserted-by":"crossref","unstructured":"Oluwasanjo A, Kartan S, Johnson W, Alpdogan O, Gru A, Mishra A, et al. Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS). Cancer Treat Res 2019;176:83\u201398. doi: 10.1007\/978-3-319-99716-2_4","DOI":"10.1007\/978-3-319-99716-2_4"},{"key":"10.12890\/2026_006099_ref8","doi-asserted-by":"crossref","unstructured":"Horwitz S, O\u2019Connor OA, Pro B, Tr\u00fcmper L, Iyer S, Advani R, et al. The ECHELON-2 Trial: 5-year results of a randomized, phase III study of brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma. Ann Oncol 2022;33:288\u2013298. doi: 10.1016\/j.annonc.2021.12.002","DOI":"10.1016\/j.annonc.2021.12.002"},{"key":"10.12890\/2026_006099_ref9","doi-asserted-by":"crossref","unstructured":"Ellin F, Landstr\u00f6m J, Jerkeman M, Relander T. Real-world data on prognostic factors and treatment in peripheral T-cell lymphomas: a study from the Swedish Lymphoma Registry. Blood 2014;124:1570\u20131577. doi: 10.1182\/blood-2014-04-573089","DOI":"10.1182\/blood-2014-04-573089"},{"key":"10.12890\/2026_006099_ref10","doi-asserted-by":"crossref","unstructured":"Shen QD, Wang L, Zhu HY, Liang JH, Xia Y, Wu JZ, et al. Gemcitabine, oxaliplatin and dexamethasone (GemDOx) as salvage therapy for relapsed or refractory diffuse large B-cell lymphoma and peripheral T-cell lymphoma. 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