{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:08:26Z","timestamp":1780582106918,"version":"3.54.1"},"reference-count":10,"publisher":"SMC Media","issue":"6","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Introduction:\u00a0Arrhythmogenic cardiomyopathies are an under-investigated common cause for myocardial infarction with no obstructive coronary artery disease. Case description:\u00a0A 56-year-old male presented with myocardial infarction with no obstructive coronary artery disease in three different occasions. His transthoracic echocardiography showed dropped left ventricle function in the last presentation. This was further investigated by cardiac magnetic resonance imaging which showed distinguishable pattern of myocardial fibrosis. He had primary prevention with an implantable cardioverter-defibrillator. He tested positive for pathological variant for the desmoplakin (DSP) gene. Conclusion:\u00a0Recurrent myocardial injury left ventricular fibrosis, and frequent premature ventricular contractions should always raise the suspicion of DSP cardiomyopathy.<\/jats:p>","DOI":"10.12890\/2026_006749","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:47:33Z","timestamp":1778856453000},"source":"Crossref","is-referenced-by-count":0,"title":["A cardiomyopathy to remember: a case report of desmoplakin cardiomyopathy"],"prefix":"10.12890","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1412-7950","authenticated-orcid":false,"given":"Tarek","family":"Mahdy","sequence":"first","affiliation":[{"name":"University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salaheldin","family":"Agamy","sequence":"first","affiliation":[{"name":"University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Khedr","sequence":"first","affiliation":[{"name":"University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Doos","sequence":"first","affiliation":[{"name":"University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Mansour","sequence":"first","affiliation":[{"name":"University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mubarak","family":"Ahamed","sequence":"first","affiliation":[{"name":"University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10397","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"10.12890\/2026_006749_ref1","doi-asserted-by":"crossref","unstructured":"Yuan ZY, Cheng LT, Wang ZF, Wu YQ. Desmoplakin and clinical manifestations of desmoplakin cardiomyopathy. Chin Med J (Engl) 2021;134:1771-1779. doi: 10.1097\/CM9.0000000000001581","DOI":"10.1097\/CM9.0000000000001581"},{"key":"10.12890\/2026_006749_ref2","doi-asserted-by":"crossref","unstructured":"Schoonvelde SAC, Hirsch A, Yap SC, Verhagen JMA, van Slegtenhorst MA, Segers Det al. Desmoplakin cardiomyopathy-an inherited cardiomyopathy presenting with recurrent episodes of acute myocardial injury. Neth Heart J;31:282-286. doi: 10.1007\/s12471-022-01735-2","DOI":"10.1007\/s12471-022-01735-2"},{"key":"10.12890\/2026_006749_ref3","doi-asserted-by":"crossref","unstructured":"Wang W, Murray B, Tichnell C, Gilotra NA, Zimmerman SL, Gasperetti A, et al. Clinical characteristics and risk stratification of desmoplakin cardiomyopathy. Europace 2022;24:268-277. doi: 10.1093\/europace\/euab183","DOI":"10.1093\/europace\/euab183"},{"key":"10.12890\/2026_006749_ref4","doi-asserted-by":"crossref","unstructured":"Brand\u00e3o M, Bariani R, Rigato I, Bauce B. Desmoplakin Cardiomyopathy: Comprehensive Review of an Increasingly Recognized Entity. J Clin Med 2023;12:2660. doi: 10.3390\/jcm12072660","DOI":"10.3390\/jcm12072660"},{"key":"10.12890\/2026_006749_ref5","doi-asserted-by":"crossref","unstructured":"Smith ED, Lakdawala NK, Papoutsidakis N, Aubert G, Mazzanti A, McCanta AC, et al. Desmoplakin Cardiomyopathy, a Fibrotic and Inflammatory Form of Cardiomyopathy Distinct From Typical Dilated or Arrhythmogenic Right Ventricular Cardiomyopathy. 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Clinical profile and long-term follow-up of a cohort of patients with desmoplakin cardiomyopathy. Heart Rhythm 2022;19:1315-1324. doi: 10.1016\/j.hrthm.2022.04.015","DOI":"10.1016\/j.hrthm.2022.04.015"},{"key":"10.12890\/2026_006749_ref9","doi-asserted-by":"crossref","unstructured":"Norgett EE, Hatsell SJ, Carvajal-Huerta L, Cabezas JC, Common J, Purkis PE, et al. Recessive mutation in desmoplakin disrupts desmoplakin-intermediate filament interactions and causes dilated cardiomyopathy, woolly hair and keratoderma. Hum Mol Genet 2000;9:2761-2766. doi: 10.1093\/hmg\/9.18.2761","DOI":"10.1093\/hmg\/9.18.2761"},{"key":"10.12890\/2026_006749_ref10","doi-asserted-by":"crossref","unstructured":"Augusto JB, Eiros R, Nakou E, Moura-Ferreira S, Treibel TA, Captur G, et al. Dilated cardiomyopathy and arrhythmogenic left ventricular cardiomyopathy: a comprehensive genotype-imaging phenotype study. 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