{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T10:49:38Z","timestamp":1791370178053,"version":"4.3.1"},"reference-count":9,"publisher":"SMC Media","issue":"10","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Introduction: Beh\u00e7et\u2019s disease (BD) is a rare chronic multisystem inflammatory disorder characterized by vasculitis of vessels of any caliber. It is classically associated with populations along the ancient Silk Road (from the Mediterranean basin to the Far East), but increasing numbers of cases are now reported in non-endemic regions, where delayed diagnosis is common due to low clinical suspicion and the absence of specific diagnostic biomarkers. Case description: We report the case of a 28-year-old man from Mexico with an 18-month history of recurrent painful oral ulcers, later associated with genital ulcers, arthralgias, and cutaneous lesions. The patient had been previously evaluated by multiple physicians and received several empirical treatments without improvement. Physical examination revealed multiple oral and genital ulcers, erythematous macular lesions on the palms and soles, and acneiform lesions on the back. Laboratory and immunological studies were unremarkable, and ophthalmological evaluation was normal. After exclusion of infectious and autoimmune diseases, Beh\u00e7et\u2019s disease was suspected. The patient met the International Criteria for Beh\u00e7et\u2019s Disease (ICBD, 2014) with a total of 5 points. Treatment with azathioprine and prednisone led to progressive clinical improvement. Conclusion: This case highlights the diagnostic challenges of Beh\u00e7et\u2019s disease in non-endemic regions. Awareness of its heterogeneous clinical spectrum and the use of validated clinical criteria are essential to avoid diagnostic delay and prevent irreversible organ damage.<\/jats:p>","DOI":"10.12890\/2026_006857","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:16:39Z","timestamp":1790255799000},"source":"Crossref","is-referenced-by-count":0,"title":["Beh\u00e7et\u2019s disease in non-endemic areas: a delayed diagnosis in a young male with recurrent bipolar aphthosis"],"prefix":"10.12890","volume":"13","author":[{"given":"Mauricio Daniel","family":"Cisneros Ch\u00e1vez","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, General Hospital of Quer\u00e9taro, Quer\u00e9taro, M\u00e9xico; Faculty of Medicine, Autonomous University of Quer\u00e9taro, Quer\u00e9taro, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego Antonio","family":"Mendoza Revilla","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Autonomous University of Quer\u00e9taro, Quer\u00e9taro, M\u00e9xico; Department of Allergy and Clinical Immunology, H+ Hospital, Quer\u00e9taro, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor Gabriel","family":"Jimenez Madrigal","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology, Canales Medical Center, Tamaulipas, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10397","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"10.12890\/2026_006857_ref1","doi-asserted-by":"crossref","unstructured":"Hi\u00e9 M, Amoura Z. Enfermedad de Beh\u00e7et. Aparato locomotor. 2017;50(3):1\u20139. doi: 10.1016\/S1286935X17860676.","DOI":"10.1016\/S1286-935X(17)86067-6"},{"key":"10.12890\/2026_006857_ref2","doi-asserted-by":"crossref","unstructured":"Emmi G, Bettiol A, Hatemi G, Prisco D. Beh\u00e7et\u2019s syndrome. Lancet. 2024;403(10431):1093\u20131108. doi: 10.1016\/S0140-6736(23)02629-6.","DOI":"10.1016\/S0140-6736(23)02629-6"},{"key":"10.12890\/2026_006857_ref3","unstructured":"Ahn CS, Strowd LC, Jorizzo JL. Enfermedad de Beh\u00e7et. En: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O\u2019Dell JR, eds. Firestein y Kelley. Tratado de reumatolog\u00eda. 12a ed. Barcelona: Elsevier Espa\u00f1a; 2026. p.1661\u20131670."},{"key":"10.12890\/2026_006857_ref4","doi-asserted-by":"crossref","unstructured":"Saadoun D, Bodaghi B, Cacoub P. Beh\u00e7et\u2019s syndrome. N Engl J Med. 2024;390(7):640\u2013651. doi: 10.1056\/NEJMra2305712.","DOI":"10.1056\/NEJMra2305712"},{"key":"10.12890\/2026_006857_ref5","doi-asserted-by":"crossref","unstructured":"Spinosa G, Rodr\u00edguez-Carballerira M. Enfermedad de Beh\u00e7et\/Beh\u00e7et\u2019s disease. Medicine (Barc). 2021;13(34):1975\u20131984. doi: 10.1016\/j.med.2021.05.010.","DOI":"10.1016\/j.med.2021.05.010"},{"key":"10.12890\/2026_006857_ref6","doi-asserted-by":"crossref","unstructured":"Hatemi G, U\u00e7ar D, Uyguno\u011flu U, Yazici H, Yazici Y. Beh\u00e7et syndrome. Rheum Dis Clin North Am. 2023;49(3):585\u2013602. doi: 10.1016\/j.rdc.2023.03.010.","DOI":"10.1016\/j.rdc.2023.03.010"},{"key":"10.12890\/2026_006857_ref7","doi-asserted-by":"crossref","unstructured":"Yazici Y, Hatemi G, Bodaghi B, Cheon JH, Suzuki N, Ambrose N, et al. Beh\u00e7et syndrome. Nat Rev Dis Primers. 2021;7(1):67. doi: 10.1038\/s41572-021-00301-1.","DOI":"10.1038\/s41572-021-00301-1"},{"key":"10.12890\/2026_006857_ref8","doi-asserted-by":"crossref","unstructured":"International Team for the Revision of the International Criteria for Beh\u00e7et\u2019s Disease (ITR-ICBD). The International Criteria for Beh\u00e7et\u2019s Disease (ICBD): a collaborative study of 27 countries on the sensitivity and specificity of the new criteria. J Eur Acad Dermatol Venereol. 2014;28(3):338\u2013347. doi: 10.1111\/jdv.12107.","DOI":"10.1111\/jdv.12107"},{"key":"10.12890\/2026_006857_ref9","doi-asserted-by":"crossref","unstructured":"Ozguler Y, Leccese P, Christensen R, Esatoglu SN, Bang D, Bodaghi B, et al. Management of major organ involvement of Beh\u00e7et\u2019s syndrome: a systematic review for update of the EULAR recommendations. Rheumatology (Oxford). 2018;57(12):2200\u20132212. doi: 10.1093\/rheumatology\/key242.","DOI":"10.1093\/rheumatology\/key242"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/ejcrim.com\/index.php\/EJCRIM\/article\/download\/6857\/5990","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ejcrim.com\/index.php\/EJCRIM\/article\/download\/6857\/5991","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ejcrim.com\/index.php\/EJCRIM\/article\/download\/6857\/5990","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:52:00Z","timestamp":1791366720000},"score":1,"resource":{"primary":{"URL":"https:\/\/ejcrim.com\/index.php\/EJCRIM\/article\/view\/6857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,24]]},"references-count":9,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.12890\/2026_006857","relation":{"has-manifestation":[{"id-type":"other","id":"1-174-6857-g5990","asserted-by":"subject"},{"id-type":"other","id":"1-174-6857-g5991","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-174","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"value":"2284-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,24]]}}}