{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T10:49:38Z","timestamp":1791370178051,"version":"4.3.1"},"reference-count":10,"publisher":"SMC Media","issue":"10","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Introduction: Severe iron deficiency anaemia (IDA) is increasingly recognized as a cause of a reversible hypercoagulable state, although simultaneous arterial and venous thrombosis are rare. Several mechanisms have been proposed, including reactive thrombocytosis, endothelial dysfunction, and changes in erythrocyte rheology, which may be secondary to reduced tissue oxygenation. Case description: We report the case of a 41-year-old woman with chronic menorrhagia due to fibroids who developed digital cyanosis and neurologic deficits due to severe microcytic anaemia (Hb 6.7 g\/dl), associated with severe iron deficiency and mild thrombocytosis (442 \u00d7109\/l). She was discharged after blood transfusion with therapy for Raynaud phenomenon (amlodipine) but returned to the emergency room due to an acute right ulnar artery occlusion complicated by internal jugular vein thrombosis that was managed with embolectomy and anticoagulation. Her digital function fully recovered, and she remained free of thrombophilia. Conclusion: Our case highlights the potential for severe IDA to cause both arterial and venous thrombosis, even in the setting of only modest platelet elevations. Chronic tobacco use may have contributed to her presentation, and clinicians should remain aware of the possibility of thrombosis in patients presenting with severe IDA who do not have other known pro-thrombotic conditions.<\/jats:p>","DOI":"10.12890\/2026_007395","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:13:16Z","timestamp":1788786796000},"source":"Crossref","is-referenced-by-count":0,"title":["Isolated ulnar artery occlusion with concurrent internal jugular vein thrombosis in severe iron-deficiency anaemia"],"prefix":"10.12890","volume":"13","author":[{"given":"Zahraa H.","family":"Alhaboobi","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Kais A.","family":"Jawish","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah Layth","family":"Alshawi","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulrahman Jihad","family":"Homsi","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Fahmawi","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albatole Imad","family":"Spereeg","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Touseef A.","family":"Kazmi","sequence":"additional","affiliation":[{"name":"Internal Medicine, Rashid Hospital, Dubai, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10397","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"10.12890\/2026_007395_ref1","doi-asserted-by":"crossref","unstructured":"Yu D, Ni Y, Chen K, Xu H, Huang X, He Y. Global burden of anemia attributable to non-communicable diseases: GBD 2021 analysis and projections. Front Nutr. 2025;12:1557986. doi: 10.3389\/fnut.2025.1557986.","DOI":"10.3389\/fnut.2025.1557986"},{"key":"10.12890\/2026_007395_ref2","doi-asserted-by":"crossref","unstructured":"Hung KC, Weng HL, Hsu CW, Lai YC, Chen IW. Association between iron deficiency anemia and risk of venous thromboembolism: a multi-institutional retrospective study. Front Nutr. 2025;12:1660622. doi: 10.3389\/fnut.2025.1660622.","DOI":"10.3389\/fnut.2025.1660622"},{"key":"10.12890\/2026_007395_ref3","doi-asserted-by":"crossref","unstructured":"Venugopalan Pathiyil D, Henry RA, Joseph J, Oomen AT, Janardhanan Kakkra J. Severe Iron Deficiency Anemia Leading to Thrombocytosis With Arterial and Venous Thrombosis. Cureus. 2021;13(9):e17893. doi: 10.7759\/cureus.17893.","DOI":"10.7759\/cureus.17893"},{"key":"10.12890\/2026_007395_ref4","doi-asserted-by":"crossref","unstructured":"Bleeker JS, Hogan WJ. Thrombocytosis: diagnostic evaluation, thrombotic risk stratification, and risk-based management strategies. Thrombosis. 2011;2011:536062. doi: 10.1155\/2011\/536062.","DOI":"10.1155\/2011\/536062"},{"key":"10.12890\/2026_007395_ref5","doi-asserted-by":"crossref","unstructured":"Mansour GK, Alshahrani WA, Alfehaid L, Alshehri AM, Al Yami MS. Anemia as a Potent and Underrecognized Driver of Venous Thromboembolism: A Systematic Review. J Clin Med. 2026;15(2):411. doi: 10.3390\/jcm15020411.","DOI":"10.3390\/jcm15020411"},{"key":"10.12890\/2026_007395_ref6","doi-asserted-by":"crossref","unstructured":"Higashi Y. Smoking cessation and vascular endothelial function. Hypertens Res. 2023;46(12):2670-2678. doi: 10.1038\/s41440-023-01455-z.","DOI":"10.1038\/s41440-023-01455-z"},{"key":"10.12890\/2026_007395_ref7","doi-asserted-by":"crossref","unstructured":"Byrnes JR, Wolberg AS. Red blood cells in thrombosis. Blood. 2017;130(16):1795-1799. doi: 10.1182\/blood-2017-03-745349.","DOI":"10.1182\/blood-2017-03-745349"},{"key":"10.12890\/2026_007395_ref8","doi-asserted-by":"crossref","unstructured":"Franchini M, Targher G, Montagnana M, Lippi G. Iron and thrombosis. Ann Hematol. 2008;87(3):167-73. doi: 10.1007\/s00277-007-0416-1.","DOI":"10.1007\/s00277-007-0416-1"},{"key":"10.12890\/2026_007395_ref9","doi-asserted-by":"crossref","unstructured":"Coutinho JM, Zuurbier SM, Gaartman AE, Dikstaal AA, Stam J, Middeldorp S, et al. Association Between Anemia and Cerebral Venous Thrombosis: Case-Control Study. Stroke. 2015;46(10):2735-40. doi: 10.1161\/STROKEAHA.115.009843.","DOI":"10.1161\/STROKEAHA.115.009843"},{"key":"10.12890\/2026_007395_ref10","unstructured":"Castellino A, Migliore E, Brignone C, Grasso M, Melchio R, Bonferroni M, Cavallero G. Iron deficiency anemia and thrombosis in young women: a report of 9 cases. Ital J Gender-Specific Med. 2022;8(1):10-17. doi: 10.1723\/3769.37562."}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/ejcrim.com\/index.php\/EJCRIM\/article\/download\/7395\/5966","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ejcrim.com\/index.php\/EJCRIM\/article\/download\/7395\/5967","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ejcrim.com\/index.php\/EJCRIM\/article\/download\/7395\/5967","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:51:56Z","timestamp":1791366716000},"score":1,"resource":{"primary":{"URL":"https:\/\/ejcrim.com\/index.php\/EJCRIM\/article\/view\/7395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,7]]},"references-count":10,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.12890\/2026_007395","relation":{"has-manifestation":[{"id-type":"other","id":"1-174-7395-g5966","asserted-by":"subject"},{"id-type":"other","id":"1-174-7395-g5967","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-174","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"value":"2284-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,7]]}}}