{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T05:43:39Z","timestamp":1769233419232,"version":"3.49.0"},"reference-count":5,"publisher":"SMC Media","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Cutaneous angiosarcoma is a rare, highly malignant tumour of vascular endothelial origin. It usually arises in the skin and superficial soft tissue, mostly on the head and neck. It presents as a variety of lesions, and so is considered a great mimicker, leading to a delay in diagnosis and evidencing the importance of biopsy with immunohistochemistry confirmation. There are few reports of extremity involvement in patients with pre-existing chronic lymphoedema, or exposure to radiation therapy. We report the case of an 82-year-old woman with lower limb extensive cutaneous involvement, distant metastatic disease, and poor therapy response. Its rare location without predisposing factors highlights the need to raise awareness about this disease<\/jats:p>","DOI":"10.12890\/2020_001939","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T09:52:37Z","timestamp":1621936357000},"source":"Crossref","is-referenced-by-count":1,"title":["Cutaneous Angiosarcoma in an Unusual Location and Without Predisposing Factors"],"prefix":"10.12890","volume":"7","author":[{"given":"Ana Oliveira","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"In\u00eas","family":"Branco Ferreira","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Centro Hospitalar Universit\u00e1rio de S. Jo\u00e3o, Porto, Portugal"}]},{"given":"Artur","family":"C\u00e9sar","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Centro Hospitalar de Vila Nova de Gaia\/Espinho, Porto, Portugal"}]},{"given":"Alberto","family":"Mota","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology and Faculty of Medicine of the University of Porto, Centro Hospitalar Universit\u00e1rio de S.Jo\u00e3o, Porto, Portugal"}]},{"given":"Jorge","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Department of Pathology and Faculty of Medicine of the University of Porto, Centro Hospitalar Universit\u00e1rio de S. Jo\u00e3o, Porto, Portugal"}]},{"given":"Jos\u00e9","family":"Manuel Lopes","sequence":"additional","affiliation":[{"name":"Department of Pathology and Faculty of Medicine of the University of Porto, Centro Hospitalar Universit\u00e1rio de S. Jo\u00e3o, Porto, Portugal"}]},{"given":"M Teresa","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Centro Hospitalar Universit\u00e1rio de S. Jo\u00e3o, Porto, Portugal"}]}],"member":"10397","published-online":{"date-parts":[[2020,9,25]]},"reference":[{"key":"10.12890\/2020_001939_ref1","doi-asserted-by":"crossref","unstructured":"<li>Nakano K, Takahashi S. Precision medicine in soft tissue sarcoma treatment. <em>Cancers<\/em> 2020;<strong>12<\/strong>:221.<\/li>","DOI":"10.3390\/cancers12010221"},{"key":"10.12890\/2020_001939_ref2","unstructured":"<li>Cao J, Wang J, He C, Fang M. Angiosarcoma: a review of diagnosis and current treatment. <em>Am J Cancer Res<\/em> 2019;<strong>9<\/strong>(11):2303\u20132313.<\/li>"},{"key":"10.12890\/2020_001939_ref3","doi-asserted-by":"crossref","unstructured":"<li>Requena C, Alsina M, Morgado-Carrasco D, Cruz J, Sanmart\u00edn O, Serra-Guill\u00e9n C, et al. Sarcoma de Kaposi y angiosarcoma cut\u00e1neo: directrices para el diagn\u00f3stico y tratamiento. <em>Actas Dermo-Sifiliogr\u00e1ficas<\/em> 2018;<strong>109<\/strong>(10):878\u2013887.<\/li>","DOI":"10.1016\/j.ad.2018.06.013"},{"key":"10.12890\/2020_001939_ref4","doi-asserted-by":"crossref","unstructured":"<li>Lewcun JA, Pameijer C, Kass R, Cream L, Hershock D, Brooks AJ, et al. Doxorubicin, paclitaxel, and cisplatin based chemotherapy for the treatment of angiosarcoma: two case reports. <em>Int J Surg Case Rep<\/em> 2020;<strong>68<\/strong>:83\u201387.<\/li>","DOI":"10.1016\/j.ijscr.2020.02.036"},{"key":"10.12890\/2020_001939_ref5","doi-asserted-by":"crossref","unstructured":"<li>Fujisawa Y, Yoshino K, Fujimura T, Nakamura Y, Okiyama N, Ishitsuka Y, et al. Cutaneous angiosarcoma: the possibility of new treatment options especially for patients with large primary tumor. <em>Front Oncol<\/em> 2018;<strong>8<\/strong>:46.<\/li>","DOI":"10.3389\/fonc.2018.00046"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/1939\/2355","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/1939\/2356","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/1939\/2356","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T12:17:45Z","timestamp":1756469865000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/1939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,25]]},"references-count":5,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.12890\/2020_001939","relation":{"has-manifestation":[{"id-type":"other","id":"1-65-1939-g2355","asserted-by":"subject"},{"id-type":"other","id":"1-65-1939-g2356","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-65","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"value":"2284-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,25]]},"article-number":"46"}}