{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T02:53:06Z","timestamp":1764557586214,"version":"3.44.0"},"reference-count":5,"publisher":"SMC Media","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>L-asparaginase is used for the treatment of acute lymphoblastic leukaemia. Hypertriglyceridaemia is a side effect and associated with potentially fatal complications, including acute pancreatitis. Plasmapheresis may have a role in treatment when triglycerides are &gt;2000 mg\/dl. We report the case of a 39-year-old woman treated with L-asparaginase for acute lymphoblastic leukaemia, who developed severe hypertriglyceridaemia (6560 mg\/dl) and acute pancreatitis. Intravenous insulin infusion was started, along with fenofibrate and atorvastatin administration, and platelet transfusion. Plasmapheresis was carried out leading to a frank decline in serum triglyceride levels (366 mg\/dl), a decrease in pancreatic enzymes and clinical improvement. The diagnosis of pancreatitis secondary to L-asparaginase should lead to immediate drug withdrawal, and plasmapheresis should be considered when serum triglyceride values exceed 2000 mg\/dl. In our case, there was a 95% triglyceride removal rate. This response illustrates the strong effectiveness of early treatment with plasmapheresis in severe and symptomatic hypertriglyceridaemia associated with L-asparaginase.<\/jats:p>","DOI":"10.12890\/2021_002342","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T09:52:37Z","timestamp":1621936357000},"source":"Crossref","is-referenced-by-count":3,"title":["Severe L-asparaginase-induced Hypertriglyceridaemia Treated with Plasmapheresis"],"prefix":"10.12890","volume":"8","author":[{"given":"Jos\u00e9","family":"Silvano","sequence":"additional","affiliation":[{"name":"Nephrology Department, Centro Hospitalar e Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"N\u00eddia","family":"Marques","sequence":"additional","affiliation":[{"name":"Nephrology Department, Centro Hospitalar e Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Isabel","family":"Tavares","sequence":"additional","affiliation":[{"name":"Nephrology Department, Centro Hospitalar e Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"In\u00eas","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Nephrology Department, Centro Hospitalar e Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, Portugal"}]}],"member":"10397","published-online":{"date-parts":[[2021,2,18]]},"reference":[{"key":"10.12890\/2021_002342_ref1","doi-asserted-by":"crossref","unstructured":"<li>Abshire TC, Pollock BH, Billett AL, Bradley P, Buchanan GR. Weekly polyethylene glycol conjugated L-asparaginase compared with bi-weekly dosing produces superior induction remission rates in childhood relapsed acute lymphoblastic leukemia: a Pediatric Oncology Group Study.<em> Blood<\/em> 2000;<strong>96<\/strong>(5):1709\u20131715.<\/li>","DOI":"10.1182\/blood.V96.5.1709.h8001709_1709_1715"},{"key":"10.12890\/2021_002342_ref2","doi-asserted-by":"crossref","unstructured":"<li>Bhojwani D, Darbandi R, Pei D, Ramsey LB, Chemaitilly W, Sandlund JT, et al. Severe hypertriglyceridaemia during therapy for childhood acute lymphoblastic leukaemia. <em>Eur J Cancer<\/em> 2014;<strong>50<\/strong>(15):2685\u20132694.<\/li>","DOI":"10.1016\/j.ejca.2014.06.023"},{"key":"10.12890\/2021_002342_ref3","unstructured":"<li>Wlaz?owski M, Celi\u00f1ska W, Maciejka-Kapu\u0153ci\u00f1ska LP, ?oszy\u00f1ska A, Idczak E. Acute pancreatitis in children with acute lymphoblastic leukemia treated with L-asparaginase. <em>Pol Tyg Lek<\/em> 1994;49(12\u201313):296\u2013297.<\/li>"},{"key":"10.12890\/2021_002342_ref4","doi-asserted-by":"crossref","unstructured":"<li>Kfoury-Baz EM, Nassar RA, Tanios RF, Otrock ZK, Youssef AM, Albany C, et al. Plasmapheresis in asparaginase-induced hypertriglyceridemia. <em>Transfusion<\/em> 2008;<strong>48<\/strong>(6):1227\u20131230.<\/li>","DOI":"10.1111\/j.1537-2995.2008.01663.x"},{"key":"10.12890\/2021_002342_ref5","doi-asserted-by":"crossref","unstructured":"<li>Rawla P, Sunkara T, Thandra KC, Gaduputi V. Hypertriglyceridemia-induced pancreatitis: updated review of current treatment and preventive strategies. <em>Clin J Gastroenterol<\/em> 2018;<strong>11<\/strong>(6):441\u2013448.<\/li>","DOI":"10.1007\/s12328-018-0881-1"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2342\/2564","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2342\/2565","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/2342\/2565","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:42:57Z","timestamp":1756374177000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/2342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,18]]},"references-count":5,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.12890\/2021_002342","relation":{"has-manifestation":[{"id-type":"other","id":"1-67-2342-g2564","asserted-by":"subject"},{"id-type":"other","id":"1-67-2342-g2565","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-67","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2021,2,18]]},"article-number":"13"}}