{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:07:15Z","timestamp":1755907635013,"version":"3.44.0"},"reference-count":7,"publisher":"SMC Media","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Adults infected with SARS-CoV-2 may develop a multisystem inflammatory syndrome (MIS-A) characterized by elevated inflammatory markers and multisystem organ involvement. We report the case of a patient who presented with fever and vomiting at hospital admission. He tested positive for SARS-CoV-2 infection and blood tests showed elevated inflammatory markers. The patient developed acute cardiac dysfunction and shock in less than 24 hours and the echocardiogram revealed an LVEF of 30%. He was discharged 3 weeks later fully recovered. MIS-A should be considered if a compatible syndrome is observed in patients with evidence of SARS-CoV-2 infection by PCR test or serology.<\/jats:p>","DOI":"10.12890\/2021_003025","type":"journal-article","created":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T05:47:06Z","timestamp":1637905626000},"source":"Crossref","is-referenced-by-count":0,"title":["SARS-CoV-2-related Multisystem Inflammatory Syndrome in Adults"],"prefix":"10.12890","volume":"8","author":[{"given":"Antonio","family":"Martins","sequence":"additional","affiliation":[{"name":"Infectious Diseases Intensive Care Unit, Infectious Diseases Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, Portugal; Department of Medicine, Faculdade de Medicina da Universidade do Porto, Porto, Portugal"}]},{"given":"S\u00edlvia","family":"Policarpo","sequence":"additional","affiliation":[{"name":"Infectious Diseases Intensive Care Unit, Infectious Diseases Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, Portugal; Department of Medicine, Faculdade de Medicina da Universidade do Porto, Porto, Portugal"}]},{"given":"Andr\u00e9","family":"Silva Pinto","sequence":"additional","affiliation":[{"name":"Infectious Diseases Intensive Care Unit, Infectious Diseases Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, Portugal; Department of Medicine, Faculdade de Medicina da Universidade do Porto, Porto, Portugal; Nephrology and Infectious Diseases R&D, i3S \u2013 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto, Porto, Portugal"}]},{"given":"Ana Sofia","family":"Santos","sequence":"additional","affiliation":[{"name":"Infectious Diseases Intensive Care Unit, Infectious Diseases Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, Portugal; Department of Medicine, Faculdade de Medicina da Universidade do Porto, Porto, Portugal"}]},{"given":"Paulo","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Infectious Diseases Intensive Care Unit, Infectious Diseases Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, Portugal; Department of Medicine, Faculdade de Medicina da Universidade do Porto, Porto, Portugal"}]},{"given":"Ant\u00f3nio","family":"Sarmento","sequence":"additional","affiliation":[{"name":"Infectious Diseases Intensive Care Unit, Infectious Diseases Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, Portugal; Department of Medicine, Faculdade de Medicina da Universidade do Porto, Porto, Portugal; Nephrology and Infectious Diseases R&D, i3S \u2013 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto, Porto, Portugal"}]},{"given":"Lurdes","family":"Santos","sequence":"additional","affiliation":[{"name":"Infectious Diseases Intensive Care Unit, Infectious Diseases Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, Portugal; Department of Medicine, Faculdade de Medicina da Universidade do Porto, Porto, Portugal; Nephrology and Infectious Diseases R&D, i3S \u2013 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto, Porto, Portugal"}]}],"member":"10397","published-online":{"date-parts":[[2021,11,26]]},"reference":[{"key":"10.12890\/2021_003025_ref1","unstructured":"<li>Centers for Disease Control and Prevention. Information for healthcare providers about multisystem inflammatory syndrome in children (MIS-C). Available from: https:\/\/www.cdc.gov\/mis-c\/hcp\/ (accessed 10 Oct 2021).<\/li>"},{"key":"10.12890\/2021_003025_ref2","unstructured":"<li>Centers for Disease Control and Prevention. Multisystem inflammatory syndrome in adults (MIS-A). Available from: https:\/\/www.cdc.gov\/mis-c\/mis-a.html (accessed 10 Oct 2021).<\/li>"},{"key":"10.12890\/2021_003025_ref3","doi-asserted-by":"crossref","unstructured":"<li>Morris SB, Schwartz NG, Patel P, Abbo L, Beauchamps L, Balan S, et al. Case series of multisystem inflammatory syndrome in adults associated with SARS-CoV-2 infection - United Kingdom and United States, March-August 2020. <em>MMWR Morb Mortal Wkly Rep<\/em> 2020;<strong>69<\/strong>(40):1450\u20131456. doi:10.15585\/mmwr.mm6940e1.<\/li>","DOI":"10.15585\/mmwr.mm6940e1"},{"key":"10.12890\/2021_003025_ref4","doi-asserted-by":"crossref","unstructured":"<li>Bastug A, Aslaner H, Bilir YA, Kemirtlek N, Gursoy FM, Bastug S, et al. Multiple system inflammatory syndrome associated with SARS-CoV-2 infection in an adult and an adolescent. <em>Rheumatol Int<\/em> 2021;<strong>41<\/strong>:993\u20131008. doi:10.1007\/s00296-021-04843-1. <\/li>","DOI":"10.1007\/s00296-021-04843-1"},{"key":"10.12890\/2021_003025_ref5","doi-asserted-by":"crossref","unstructured":"<li>Chau VQ, Giustino G, Mahmood K, Oliveros E, Neibart E, Oloomi M, et al. Cardiogenic shock and hyperinflammatory syndrome in young males with COVID-19.<em>Circ Heart Fail<\/em> 2020;<strong>13<\/strong>(10):e007485. doi:10.1161\/CIRCHEARTFAILURE.120.007485. <\/li>","DOI":"10.1161\/CIRCHEARTFAILURE.120.007485"},{"key":"10.12890\/2021_003025_ref6","doi-asserted-by":"crossref","unstructured":"<li>H\u00e9kimian G, Kerneis M, Zeitouni M, Cohen-Aubart F, Chommeloux J, Br\u00e9chot N, et al. COVID-19 acute myocarditis and multisystem inflammatory syndrome in adult intensive and cardiac care units. <em>Chest<\/em> 2020;<strong>159<\/strong>(2):657\u2013662. doi:10.1016\/j.chest.2020.08.2099.<\/li>","DOI":"10.1016\/j.chest.2020.08.2099"},{"key":"10.12890\/2021_003025_ref7","doi-asserted-by":"crossref","unstructured":"<li>Henderson LA, Canna SW, Friedman KG, Gorelik M, Lapidus SK, Bassiri H, et al. American College of Rheumatology clinical guidance for multisystem inflammatory syndrome in children associated with SARS-CoV-2 and hyperinflammation in pediatric COVID-19: version 2. <em>Arthritis Rheumatol<\/em> 2021;<strong>73<\/strong>(4):e13\u201329. doi:10.1002\/art.41616.<\/li>","DOI":"10.1002\/art.41616"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3025\/2906","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3025\/2907","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3025\/2907","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T12:18:23Z","timestamp":1755865103000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/3025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,26]]},"references-count":7,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.12890\/2021_003025","relation":{"has-manifestation":[{"id-type":"other","id":"1-79-3025-g2906","asserted-by":"subject"},{"id-type":"other","id":"1-79-3025-g2907","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-79","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2021,11,26]]},"article-number":"6"}}