{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T23:36:16Z","timestamp":1759448176283,"version":"3.44.0"},"reference-count":5,"publisher":"SMC Media","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Primary adrenal lymphoma (PAL) is a very rare type of non-Hodgkin\u2019s lymphoma (NHL). Herein, we report a case of NHL of both adrenal glands in a 69-year-old man. The patient was admitted because of a 1-month history of B symptoms and symptomatic hypotension. Biochemical analysis showed normocytic normochromic anaemia, hyponatraemia, hyperkalaemia, and elevated lactate dehydrogenase, C-reactive protein and D-dimers. A computed tomography scan revealed bilateral enlargement of the adrenal glands. There was no evidence of endocrine adrenal dysfunction. The mass in the right adrenal gland was biopsied and histopathology identified a diffuse large B-cell lymphoma of the activated B-cell subtype. A positron emission tomography 18F-fluorodeoxyglucose scan showed intensive hypermetabolic lesions involving both adrenal glands, as well as other locations, with higher uptake in the adrenal glands. Taken together, these findings suggested the diagnosis of PAL. The patient responded favourably to debulking therapy and is currently undergoing chemotherapy.<\/jats:p>","DOI":"10.12890\/2022_003116","type":"journal-article","created":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T03:40:36Z","timestamp":1642045236000},"source":"Crossref","is-referenced-by-count":1,"title":["Primary Adrenal Lymphoma: When B Symptoms Appear Hand in Hand with Adrenal Masses"],"prefix":"10.12890","volume":"9","author":[{"given":"David","family":"Lopes Sousa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal"}]},{"given":"Sandra","family":"D. Santos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal"}]},{"given":"Jo\u00e3o","family":"Pina Cabral","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal"}]},{"given":"Ricardo","family":"Velho","sequence":"additional","affiliation":[{"name":"Department of Internal MediDepartment of Internal Medicine, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugalcine, Centro Hospitalar e Universit\u00e1rio de Coimbra"}]},{"given":"Ana Sofia","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal"}]},{"given":"Pedro","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal"}]}],"member":"10397","published-online":{"date-parts":[[2022,1,13]]},"reference":[{"key":"10.12890\/2022_003116_ref1","doi-asserted-by":"crossref","unstructured":"<li>Rashidi A, Fisher SI. Primary adrenal lymphoma: a systematic review. <em>Ann Hematol <\/em>2013;<strong>92<\/strong>(12):1583\u20131593. doi: 10.1007\/s00277-013-1812-3. <\/li>","DOI":"10.1007\/s00277-013-1812-3"},{"key":"10.12890\/2022_003116_ref2","doi-asserted-by":"crossref","unstructured":"<li>Wang Y, Ren Y, Ma L, Li J, Zhu Y, Zhao L, et al. Clinical features of 50 patients with primary adrenal lymphoma. <em>Front Endocrinol (Lausanne)<\/em> 2020;<strong>11<\/strong>:595. doi: 10.3389\/fendo.2020.00595.<\/li>","DOI":"10.3389\/fendo.2020.00595"},{"key":"10.12890\/2022_003116_ref3","doi-asserted-by":"crossref","unstructured":"<li>Laurent C, Casasnovas O, Martin L, Chauchet A, Ghesquieres H, Aussedat G, et al. Adrenal lymphoma: presentation, management and prognosis. <em>QJM<\/em> 2017;<strong>110<\/strong>(2):103\u2013109. doi: 10.1093\/qjmed\/hcw174.<\/li>","DOI":"10.1093\/qjmed\/hcw174"},{"key":"10.12890\/2022_003116_ref4","doi-asserted-by":"crossref","unstructured":"<li>de Sousa Lages A, Bastos M, Oliveira P, Carrilho F. Diffuse large B-cell lymphoma of the adrenal gland: a rare cause of primary adrenal insufficiency. <em>BMJ Case Rep<\/em> 2016;<strong>2016<\/strong>:bcr2016214920. doi: 10.1136\/bcr-2016-214920.<\/li>","DOI":"10.1136\/bcr-2016-214920"},{"key":"10.12890\/2022_003116_ref5","doi-asserted-by":"crossref","unstructured":"<li>Ferreira R, Moniz C, Serra F, Fonseca R, Sim\u00f5es H, Oliveira M, et al. Primary lymphoma of bilateral adrenal. <em>Rev Port Endocrinol Diabetes Metab<\/em> 2014;<strong>9<\/strong>:149\u2013152.<\/li>","DOI":"10.1016\/j.rpedm.2014.07.005"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3116\/2959","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3116\/2960","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3116\/2960","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T12:01:12Z","timestamp":1755864072000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/3116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,13]]},"references-count":5,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.12890\/2022_003116","relation":{"has-manifestation":[{"id-type":"other","id":"1-81-3116-g2959","asserted-by":"subject"},{"id-type":"other","id":"1-81-3116-g2960","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-81","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"type":"electronic","value":"2284-2594"}],"subject":[],"published":{"date-parts":[[2022,1,13]]},"article-number":"14"}}