{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T05:51:46Z","timestamp":1778651506799,"version":"3.51.4"},"reference-count":5,"publisher":"SMC Media","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Pulmonary alveolar microlithiasis (PAM) is a genetic lung disorder that is characterized by the accumulation of calcium phosphate deposits in the alveolar spaces of the lung. PAM is discovered incidentally on radiographs performed for other purposes, and the typical disease course is characterized by slowly progressive respiratory failure over decades. Treatment remains supportive. A 62-year-old woman presented in the emergency department with dyspnoea and fatigue. On physical examination she had crackles on pulmonary auscultation and digital clubbing. A CT scan of the chest showed multiple high-density areas throughout the lung parenchyma, suggesting the presence of alveolar microlithiasis. This CT finding is the typical radiological presentation of PAM, while the hallmark presentation is clinical\u2013radiological dissociation.<\/jats:p>","DOI":"10.12890\/2022_003575","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T03:21:06Z","timestamp":1666063266000},"source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic Images of Pulmonary Alveolar Microlithiasis: A Rare, Autosomal Recessive Disorder"],"prefix":"10.12890","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7952-0046","authenticated-orcid":false,"given":"Fabia","family":"Cruz","sequence":"first","affiliation":[{"name":"Internal Medicine Service, Hospital Amato Lusitano, ULSCB, Castelo Branco, Portugal"}]},{"given":"Diogo","family":"Batista","sequence":"first","affiliation":[{"name":"Pneumology Service, Hospital Santa Maria, CHULN, Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9247-2571","authenticated-orcid":false,"given":"C\u00e1tia","family":"Pereira","sequence":"first","affiliation":[{"name":"Pneumology Service, Hospital Santa Maria, CHULN, Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1199-3741","authenticated-orcid":false,"given":"Vera","family":"Dur\u00e3o","sequence":"first","affiliation":[{"name":"Pneumology Service, Hospital Santa Maria, CHULN, Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3969-0200","authenticated-orcid":false,"given":"Rita","family":"Macedo","sequence":"first","affiliation":[{"name":"Pneumology Service, Hospital Santa Maria, CHULN, Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2218-8537","authenticated-orcid":false,"given":"Richard","family":"Staats","sequence":"first","affiliation":[{"name":"Pneumology Service, Hospital Santa Maria, CHULN, Lisbon, Portugal; Faculty of Medicine of Lisbon, ISAMB, Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2301-2752","authenticated-orcid":false,"given":"Paula","family":"Pinto","sequence":"first","affiliation":[{"name":"Pneumology Service, Hospital Santa Maria, CHULN, Lisbon, Portugal; Faculty of Medicine of Lisbon, ISAMB, Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0915-4105","authenticated-orcid":false,"given":"Cristina","family":"B\u00e1rbara","sequence":"first","affiliation":[{"name":"Pneumology Service, Hospital Santa Maria, CHULN, Lisbon, Portugal; Faculty of Medicine of Lisbon, ISAMB, Lisbon, Portugal"}]}],"member":"10397","published-online":{"date-parts":[[2022,10,18]]},"reference":[{"key":"10.12890\/2022_003575_ref1","doi-asserted-by":"crossref","unstructured":"<li>Saito A, McCormack FX. Pulmonary alveolar microlithiasis. <em>Clin Chest Med<\/em> 2016 Sep;<strong>37<\/strong>(3):441\u2013448. <\/li>","DOI":"10.1016\/j.ccm.2016.04.007"},{"key":"10.12890\/2022_003575_ref2","doi-asserted-by":"crossref","unstructured":"<li>Kosciuk P, Meyer C, Wikenheiser-Brokamp KA, McCormack FX. Pulmonary alveolar microlithiasis. <em>Eur Respir Rev<\/em> 2020 Nov 27;<strong>29<\/strong>(158):200024. <\/li>","DOI":"10.1183\/16000617.0024-2020"},{"key":"10.12890\/2022_003575_ref3","doi-asserted-by":"crossref","unstructured":"<li>Samrah S, Shraideh H, Rawashdeh S, Khassawneh B. Tricuspid valve calcification in familial pulmonary alveolar microlithiasis: a case report. <em>Ann Med Surg<\/em> 2020;<strong>55<\/strong>:256\u2013259.<\/li>","DOI":"10.1016\/j.amsu.2020.05.039"},{"key":"10.12890\/2022_003575_ref4","doi-asserted-by":"crossref","unstructured":"<li>Alkhankan E, Yamin H, Bukamur H, Alkhankan F, Shweihat Y, Zeid F. Pulmonary alveolar microlithiasis diagnosed with radiography, CT, and bone scintigraphy. <em>Radiol Case Rep<\/em> 2019;<strong>14<\/strong>:775\u2013777.<\/li>","DOI":"10.1016\/j.radcr.2019.03.032"},{"key":"10.12890\/2022_003575_ref5","doi-asserted-by":"crossref","unstructured":"<li>Al-Maghrabi H, Mokhtar G, Al-Maghrabi J, Meliti A. Pulmonary alveolar microlithiasis: a report of two unique cases. <em>Respir Med Case Rep<\/em> 2020;<strong>29<\/strong>:100980.<\/li>","DOI":"10.1016\/j.rmcr.2019.100980"}],"container-title":["European Journal of Case Reports in Internal Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3575\/3262","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3575\/3263","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/download\/3575\/3263","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T13:55:35Z","timestamp":1755784535000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejcrim.com\/index.php\/EJCRIM\/article\/view\/3575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,18]]},"references-count":5,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.12890\/2022_003575","relation":{"has-manifestation":[{"id-type":"other","id":"1-91-3575-g3262","asserted-by":"subject"},{"id-type":"other","id":"1-91-3575-g3263","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"1-91","asserted-by":"subject"}]},"ISSN":["2284-2594"],"issn-type":[{"value":"2284-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,18]]}}}