{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T14:35:15Z","timestamp":1781620515928,"version":"3.54.5"},"reference-count":38,"publisher":"Japanese Society of Hypertension","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hypertens Res"],"published-print":{"date-parts":[[2007]]},"DOI":"10.1291\/hypres.30.1029","type":"journal-article","created":{"date-parts":[[2008,2,4]],"date-time":"2008-02-04T05:52:36Z","timestamp":1202104356000},"page":"1029-1034","source":"Crossref","is-referenced-by-count":134,"title":["Low Testosterone Level Is an Independent Determinant of Endothelial Dysfunction in Men"],"prefix":"10.1291","volume":"30","author":[{"given":"Masahiro","family":"AKISHITA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"HASHIMOTO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"OHIKE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumito","family":"OGAWA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuya","family":"IIJIMA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"ETO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyoshi","family":"OUCHI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"119","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5337.419"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Muller M, den Tonkelaar I, Thijssen JH, Grobbee DE, van der Schouw YT: Endogenous sex hormones in men aged 40−80 years. Eur J Endocrinol<\/i> 2003; 149<\/b>: 583-589.","DOI":"10.1530\/eje.0.1490583"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Kaufman JM, Vermeulen A: The decline of androgen levels in elderly men and its clinical and therapeutic implications. Endocr Rev<\/i> 2005; 26<\/b>: 833-876.","DOI":"10.1210\/er.2004-0013"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Hak AE, Witteman JC, de Jong FH, Geerlings MI, Hofman A, Pols HA: Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: the Rotterdam study. J Clin Endocrinol Metab<\/i> 2002; 87<\/b>: 3632-3639.","DOI":"10.1210\/jcem.87.8.8762"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. van den Beld AW, Bots ML, Janssen JA, Pols HA, Lamberts SW, Grobbee DE: Endogenous hormones and carotid atherosclerosis in elderly men. Am J Epidemiol<\/i> 2003; 157<\/b>: 25-31.","DOI":"10.1093\/aje\/kwf160"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Feldman HA, Johannes CB, McKinlay JB, Longcope C: Low dehydroepiandrosterone sulfate and heart disease in middle-aged men: cross-sectional results from the Massachusetts Male Aging Study. Ann Epidemiol<\/i> 1998; 8<\/b>: 217-228.","DOI":"10.1016\/S1047-2797(97)00199-3"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Simon D, Charles MA, Nahoul K, et al<\/i>: Association between plasma total testosterone and cardiovascular risk factors in healthy adult men: the Telecom Study. J Clin Endocrinol Metab<\/i> 1997; 82<\/b>: 682-685.","DOI":"10.1210\/jc.82.2.682"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Barrett-Connor E, Khaw KT: Endogenous sex hormones and cardiovascular disease in men. A prospective population-based study. Circulation<\/i> 1988; 78<\/b>: 539-545.","DOI":"10.1161\/01.CIR.78.3.539"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.28.625"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Stellato RK, Feldman HA, Hamdy O, Horton ES, McKinlay JB: Testosterone, sex hormone−binding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts Male Aging Study. Diabetes Care<\/i> 2000; 23<\/b>: 490-494.","DOI":"10.2337\/diacare.23.4.490"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Rosano GM, Leonardo F, Pagnotta P, et al<\/i>: Acute anti-ischemic effect of testosterone in men with coronary artery disease. Circulation<\/i> 1999; 99<\/b>: 1666-1670.","DOI":"10.1161\/01.CIR.99.13.1666"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. English KM, Steeds RP, Jones TH, Diver MJ, Channer KS: Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina: a randomized, double-blind, placebo-controlled study. Circulation<\/i> 2000; 102<\/b>: 1906-1911.","DOI":"10.1161\/01.CIR.102.16.1906"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Ong PJ, Patrizi G, Chong WC, Webb CM, Hayward CS, Collins P: Testosterone enhances flow-mediated brachial artery reactivity in men with coronary artery disease. Am J Cardiol<\/i> 2000; 85<\/b>: 269-272.","DOI":"10.1016\/S0002-9149(99)00630-X"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)02202-6"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Japanese Society of Hypertension: Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2004). Hypertens Res<\/i> 2006; 29<\/b> (Suppl): S1-S105.","DOI":"10.1291\/hypres.29.S1"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2486"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. American Diabetes Association: Screening for diabetes (Position statement). Diabetes Care<\/i> 2001; 24<\/b> (Suppl): S21-S24.","DOI":"10.2337\/diacare.25.2007.S21"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Hashimoto M, Eto M, Akishita M, et al<\/i>: Correlation between flow-mediated vasodilatation of the brachial artery and intima-media thickness in the carotid artery in men. Arterioscler Thromb Vasc Biol<\/i> 1999; 19<\/b>: 2795-2800.","DOI":"10.1161\/01.ATV.19.11.2795"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.28.59"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2000.00277.x"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Sewdarsen M, Vythilingum S, Jialal I, Desai RK, Becker P: Abnormalities in sex hormones are a risk factor for premature manifestation of coronary artery disease in South African Indian men. Atherosclerosis<\/i> 1990; 83<\/b>: 111-117.","DOI":"10.1016\/0021-9150(90)90156-D"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Jeppesen LL, Jorgensen HS, Nakayama H, Raaschou HO, Olsen TS, Winther K: Decreased serum testosterone in men with acute ischemic stroke. Arterioscler Thromb Vasc Biol<\/i> 1996; 16<\/b>: 749-754.","DOI":"10.1161\/01.ATV.16.6.749"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Yarnell JW, Beswick AD, Sweetnam PM, Riad-Fahmy D: Endogenous sex hormones and ischemic heart disease in men. The Caerphilly prospective study. Arterioscler Thromb<\/i> 1993; 13<\/b>: 517-520.","DOI":"10.1161\/01.ATV.13.4.517"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Arnlov J, Pencina MJ, Amin S, et al<\/i>: Endogenous sex hormones and cardiovascular disease incidence in men. Ann Intern Med<\/i> 2006; 145<\/b>: 176-184.","DOI":"10.7326\/0003-4819-145-3-200608010-00005"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Feldman HA, Johannes CB, Araujo AB, Mohr BA, Longcope C, McKinlay JB: Low dehydroepiandrosterone and ischemic heart disease in middle-aged men: prospective results from the Massachusetts Male Aging Study. Am J Epidemiol<\/i> 2001; 153<\/b>: 79-89.","DOI":"10.1093\/aje\/153.1.79"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Trivedi DP, Khaw KT: Dehydroepiandrosterone sulfate and mortality in elderly men and women. J Clin Endocrinol Metab<\/i> 2001; 86<\/b>: 4171-4177.","DOI":"10.1210\/jcem.86.9.7838"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Smith GD, Ben-Shlomo Y, Beswick A, Yarnell J, Lightman S, Elwood P: Cortisol, testosterone, and coronary heart disease: prospective evidence from the Caerphilly study. Circulation<\/i> 2005; 112<\/b>: 332-340.","DOI":"10.1161\/CIRCULATIONAHA.104.489088"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Klee GG, Heser DW: Techniques to measure testosterone in the elderly. Mayo Clin Proc<\/i> 2000; 75<\/b> (Suppl): S19-S25.","DOI":"10.1016\/S0025-6196(19)30637-8"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Webb CM, McNeill JG, Hayward CS, de Zeigler D, Collins P: Effects of testosterone on coronary vasomotor regulation in men with coronary heart disease. Circulation<\/i> 1999; 100<\/b>: 1690-1696.","DOI":"10.1161\/01.CIR.100.16.1690"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Chou TM, Sudhir K, Hutchison SJ, et al<\/i>: Testosterone induces dilation of canine coronary conductance and resistance arteries in vivo<\/i>. Circulation<\/i> 1996; 94<\/b>: 2614-2619.","DOI":"10.1161\/01.CIR.94.10.2614"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705141"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Liu PY, Death AK, Handelsman DJ: Androgens and cardiovascular disease. Endocr Rev<\/i> 2003; 24<\/b>: 313-340.","DOI":"10.1210\/er.2003-0005"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.12.119"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Kravariti M, Naka KK, Kalantaridou SN, et al<\/i>: Predictors of endothelial dysfunction in young women with polycystic ovary syndrome. J Clin Endocrinol Metab<\/i> 2005; 90<\/b>: 5088-5095.","DOI":"10.1210\/jc.2005-0151"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00416-1"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(89)90090-7"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Liu PY, Christian RC, Ruan M, Miller VM, Fitzpatrick LA: Correlating androgen and estrogen steroid receptor expression with coronary calcification and atherosclerosis in men without known coronary artery disease. J Clin Endocrinol Metab<\/i> 2005; 90<\/b>: 1041-1046.","DOI":"10.1210\/jc.2004-1211"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Christian RC, Liu PY, Harrington S, Ruan M, Miller VM, Fitzpatrick LA: Intimal estrogen receptor (ER)beta, but not ERalpha expression, is correlated with coronary calcification and atherosclerosis in pre- and postmenopausal women. J Clin Endocrinol Metab<\/i> 2006; 91<\/b>: 2713-2720.","DOI":"10.1210\/jc.2005-2672"}],"container-title":["Hypertension Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T13:07:55Z","timestamp":1588338475000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nature.com\/doifinder\/10.1291\/hypres.30.1029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":38,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2007]]}},"URL":"https:\/\/doi.org\/10.1291\/hypres.30.1029","relation":{},"ISSN":["0916-9636","1348-4214"],"issn-type":[{"value":"0916-9636","type":"print"},{"value":"1348-4214","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}