{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:16:44Z","timestamp":1790864204024,"version":"4.1.0"},"reference-count":47,"publisher":"Japanese Society of Hypertension","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hypertens Res"],"published-print":{"date-parts":[[2007]]},"DOI":"10.1291\/hypres.30.111","type":"journal-article","created":{"date-parts":[[2007,4,27]],"date-time":"2007-04-27T05:10:19Z","timestamp":1177650619000},"page":"111-117","source":"Crossref","is-referenced-by-count":98,"title":["Prevalence of Primary Aldosteronism among Unselected Hypertensive Patients: A Prospective Study Based on the Use of an Aldosterone\/Renin Ratio above 25 as a Screening Test"],"prefix":"10.1291","volume":"30","author":[{"given":"Roberto","family":"FOGARI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"PRETI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"ZOPPI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"RINALDI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"FOGARI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amedeo","family":"MUGELLINI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"119","reference":[{"key":"1","unstructured":"1. Conn JW: Primary aldosteronism, a new clinical syndrome. J Lab Clin Med<\/i> 1955; 45<\/b>: 3-7."},{"key":"2","unstructured":"2. Conn JW: The evolution of primary aldosteronism: 1954−1967. Harvey Lect<\/i> 1968; 62<\/b>: 257-291."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Kaplan NM: Commentary on the incidence of primary aldosteronism. Current estimations based on objective data. Arch Intern Med<\/i> 1969; 123<\/b>: 152-155.","DOI":"10.1001\/archinte.1969.00300120040006"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Berglund G, Andersson O, Wilhemsen L: Prevalence of primary and secondary hypertension: studies in a random population. Br Med J<\/i> 1976; 2<\/b>: 554-556.","DOI":"10.1136\/bmj.2.6035.554"},{"key":"5","unstructured":"5. Tucker R, Labarthe D: Frequency of surgical treatment for hypertension in adults at the Mayo Clinic from 1973 to 1975. Mayo Clin Proc<\/i> 1977; 52<\/b>: 549-555."},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.141.12.1589"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Moneva MH, Gomez-Sanchez CE: Establishing a diagnosis of primary aldosteronism. Curr Opin Endocrinol Diabetes<\/i> 2001; 8<\/b>: 124-129.","DOI":"10.1097\/00060793-200106000-00004"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Brown CA, Bouldin MJ, Blackston JW, Duddleston DN, Shepherd JM, Hicks GS: Hyperaldosteronism: the internist's hypertensive disease. Am J Med Sci<\/i> 2002; 324<\/b>: 227-231.","DOI":"10.1097\/00000441-200210000-00010"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Young WF: Minireview: primary aldosteronism—changing concepts in diagnosis and treatment. Endocrinology<\/i> 2003; 144<\/b>: 2208-2213.","DOI":"10.1210\/en.2003-0279"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Kem DC, Weinberger MH, Mayes DM, Nugent CA: Saline suppression of plasma aldosterone in hypertension. Arch Intern Med<\/i> 1971; 128<\/b>: 380-386.","DOI":"10.1001\/archinte.1971.00310210056004"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Lyons DF, Kem DC, Brown RD, Hanson CS, Carollo ML: Single dose captopril as a diagnostic test for primary aldosteronism. J Clin Endocrinol Metab<\/i> 1983; 57<\/b>: 892-896.","DOI":"10.1210\/jcem-57-5-892"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Holland O, Brown H, Kuhnert L: Further evaluation of saline infusion for the diagnosis of primary hyperaldosteronism. Hypertension<\/i> 1984; 6<\/b>: 717-723.","DOI":"10.1161\/01.HYP.6.5.717"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Castro OL, Yu X, Kem DC: Diagnostic value of the post-captopril test in primary aldosteronism. Hypertension<\/i> 2002; 39<\/b>: 935-938.","DOI":"10.1161\/01.HYP.0000014324.68506.CA"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Young WF: Primary aldosteronism. Management issues. Ann N Y<\/NOBR> Sci<\/i> 2002; 970<\/b>: 61-76.","DOI":"10.1111\/j.1749-6632.2002.tb04413.x"},{"issue":"4","key":"15","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1440-1681.1994.tb02519.x","volume":"21","year":"1994","ISSN":"https:\/\/id.crossref.org\/issn\/0305-1870","issn-type":"print"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.8.2854"},{"key":"17","unstructured":"17. Rayner BL, Opie LH, Davidson JS: Primary hyperaldosteronism: how common is it in patients with severe hypertension? J Hypertens<\/i> 1999; 17<\/b> (Suppl 3): S177."},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(02)02969-2"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200311000-00025"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Mosso L, Carvajal C, Gonzalez A, et al<\/i>: Primary aldosteronism and hypertensive disease. Hypertension<\/i> 2003; 42<\/b>: 161-165.","DOI":"10.1161\/01.HYP.0000079505.25750.11"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031337"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.27.1"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1038\/355262a0"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Mulatero P, Morello F, Veglio F: Genetics of primary aldosteronism. J Hypertens<\/i> 2004; 22<\/b>: 663-670.","DOI":"10.1097\/00004872-200404000-00001"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.24.469"},{"key":"26","unstructured":"26. Spoto B, Feurlo G, Gervasi A, Bresolin G, Zoccali C: Familial hyperaldosteronism. G Ital Nefrol<\/i> 2004; 21<\/b>: 139-143."},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.28.379"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.24.589"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Stowasser M, Gordon RD, Rutherford JC, Nikwan NZ, Daunt N, Slater GJ: Diagnosis and management of primary aldosteronism. J Renin Angiotensin Aldosterone Syst<\/i> 2001; 2<\/b>: 156-169.","DOI":"10.3317\/jraas.2001.022"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2002.01613.x"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.7.2573"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Mulatero P, Curnow KM, Aupetit-Faisant B, et al<\/i>: Recombinant CYP11B genes encode enzymes that can catalyse conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol and 18-oxocortisol. J Endocrinol Metab<\/i> 1998; 83<\/b>: 3996-4001.","DOI":"10.1210\/jc.83.11.3996"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.1225"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.27.193"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Tiu SC, Choi CH, Shek CC, et al<\/i>: The use of aldosterone-renin ratio (ARR) as a diagnostic test for primary hyperaldosteronism and its test characteristics under different conditions of blood sampling. J Clin Endocrinol Metab<\/i> 2005; 90<\/b>: 72-78.","DOI":"10.1210\/jc.2004-1149"},{"key":"36","unstructured":"36. Kaplan NM: Primary aldosteronism, in: Kaplan's Clinical Hypertension, 8th ed. Philadelphia, Lippincott Williams & Wilkins 2002, pp 455-479."},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Magill SB: Adrenal vein sampling: an overview. Endocrinologist<\/i> 2001; 11<\/b>: 357-363.","DOI":"10.1097\/00019616-200109000-00003"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.25.145"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Stowasser M: How common is adrenal-based mineralcorticoid hypertension? Curr Opin Endocrinol Diabetes<\/i> 2000; 7<\/b>: 143-150.","DOI":"10.1097\/00060793-200006000-00007"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1999.00070.x"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Ganguly A, Chavarri M, Luetscher JA, Dowdy AJ: Transient fall and subsequent return of high aldosterone secretion during continued dexamethasone administration. J Clin Endocrinol Metab<\/i> 1977; 44<\/b>: 775-779.","DOI":"10.1210\/jcem-44-4-775"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Reincke M, Beuschlein F, Latronico AC, Arlt W, Chrousos G, Allolio B: Expression of adrenocorticotrophic hormone receptor mRNA in human adrenocortical neoplasm: correlation with P450scc expression. Clin Endocrinol<\/i> 1997; 46<\/b>: 619-626.","DOI":"10.1046\/j.1365-2265.1997.1991009.x"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Rossi GP: Remodelling of left ventricle in primary aldosteronism due to Conn's adenoma. Circulation<\/i> 1997; 95<\/b>: 1471-1478.","DOI":"10.1161\/01.CIR.95.6.1471"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Duprez D, De Buyzere M, Rietzschel ER, Clement DL: Aldosterone and vascular damage. Curr Hypertens Rep<\/i> 2000; 2<\/b>: 327-334.","DOI":"10.1007\/s11906-000-0017-z"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.27.303"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.25.49"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47. Kaplan NM: The current epidemic of primary aldosteronism: causes and consequences. J Hypertens<\/i> 2004; 22<\/b>: 863-869.","DOI":"10.1097\/00004872-200405000-00001"}],"container-title":["Hypertension Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T14:45:27Z","timestamp":1556376327000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nature.com\/doifinder\/10.1291\/hypres.30.111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007]]}},"URL":"https:\/\/doi.org\/10.1291\/hypres.30.111","relation":{},"ISSN":["0916-9636","1348-4214"],"issn-type":[{"value":"0916-9636","type":"print"},{"value":"1348-4214","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}