{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:33:26Z","timestamp":1791113606669,"version":"4.1.0"},"reference-count":53,"publisher":"Japanese Society of Hypertension","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hypertens Res"],"published-print":{"date-parts":[[2007]]},"DOI":"10.1291\/hypres.30.427","type":"journal-article","created":{"date-parts":[[2007,6,28]],"date-time":"2007-06-28T05:53:55Z","timestamp":1183010035000},"page":"427-437","source":"Crossref","is-referenced-by-count":46,"title":["Spironolactone Modulates Expressions of Cardiac Mineralocorticoid Receptor and 11.BETA.-Hydroxysteroid Dehydrogenase 2 and Prevents Ventricular Remodeling in Post-Infarct Rat Hearts"],"prefix":"10.1291","volume":"30","author":[{"given":"Mitsuo","family":"TAKEDA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"TATSUMI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinsaku","family":"MATSUNAGA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironori","family":"HAYASHI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"KIMATA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoken","family":"HONSHO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"NISHIKAWA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"MANO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"SHIRAISHI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"YAMADA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomosaburo","family":"TAKAHASHI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoaki","family":"MATOBA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyuki","family":"KOBARA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"MATSUBARA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"119","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.46.1.455"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Tatsumi T, Shiraishi J, Keira N, et al<\/i>: Intracellular ATP is required for mitochondrial apoptotic pathways in isolated hypoxic rat cardiac myocytes. Cardiovasc Res<\/i> 2003; 52<\/b>: 428-440.","DOI":"10.1016\/S0008-6363(03)00391-2"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Fliss H, Gattinger D: Apoptosis in ischemic and reperfused rat myocardium. Circ Res<\/i> 1996; 79<\/b>: 949-956.","DOI":"10.1161\/01.RES.79.5.949"},{"key":"4","unstructured":"4. Kajstura J, Cheng W, Reiss K, et al<\/i>: Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats. Lab Invest<\/i> 1996; 74<\/b>: 86-107."},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1996.0232"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1996.0193"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Beltrami CA, Finato N, Rocco M, et al<\/i>: Structural basis of end-stage failure in ischemic cardiomyopathy in humans. Circulation<\/i> 1994; 89<\/b>: 151-163.","DOI":"10.1161\/01.CIR.89.1.151"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199704173361603"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Saraste A, Pulkki K, Kallajoki M, et al<\/i>: Cardiomyocyte apoptosis and progression of heart failure to transplantation. Eur J Clin Invest<\/i> 1999; 29<\/b>: 380-386.","DOI":"10.1046\/j.1365-2362.1999.00481.x"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Packer M: The neurohormonal hypothesis: a theory to explain the mechanism of disease progression in heart failure. J Am Coll Cardiol<\/i> 1992; 20<\/b>: 248-254.","DOI":"10.1016\/0735-1097(92)90167-L"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.27.303"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Pitt B, Zannad F, Remme WJ, et al<\/i>: The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med<\/i> 1999; 341<\/b>: 709-717.","DOI":"10.1056\/NEJM199909023411001"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030207"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Mizuno Y, Yoshimura M, Yasue H, et al<\/i>: Aldosterone production is activated in the failing ventricles in human. Circulation<\/i> 2001; 103<\/b>: 72-77.","DOI":"10.1161\/01.CIR.103.1.72"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000015905.27598.E9"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.9.4883"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2003.11.037"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.48.1.231"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Slight SH, Ganjam VK, Gomez-Sanchez CE, Zhou MY, Weber KT: High affinity NAD+<\/sup>-dependent 11β-hydroxysteroid dehydrogenase in the human heart. J Mol Cell Cardiol<\/i> 1996; 28<\/b>: 781-787.","DOI":"10.1006\/jmcc.1996.0072"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000135599.33787.CA"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Kobara M, Tatsumi T, Kambayashi D, et al<\/i>: Effect of ACE inhibition on myocardial apoptosis in an ischemia-reperfusion rat heart model. J Cardiovasc Pharmacol<\/i> 2003; 41<\/b>: 880-889.","DOI":"10.1097\/00005344-200306000-00008"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Veliotes DGA, Woodiwiss AJ, Deftereos DAJ, Gray D, Osadchii O, Norton GR: Aldosterone receptor blockade prevents the transition to cardiac pump dysfunction induced by β-adrenoreceptor activation. Hypertension<\/i> 2005; 45<\/b>: 914-920.","DOI":"10.1161\/01.HYP.0000164567.62172.c5"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Bäcklund T, Palojoki E, Saraste A, et al<\/i>: Effect of vasopeptide inhibitor omapatrilat on cardiomyocyte apoptosis and ventricular remodeling in rat myocardial infarction. Cardiovasc Res<\/i> 2003; 57<\/b>: 727-737.","DOI":"10.1016\/S0008-6363(02)00721-6"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Delyani JA, Robinson EL, Rudolph AE: Effect of a selective aldosterone receptor antagonist in myocardial infarction. Am J Physiol<\/i> 2001; 50<\/b>: H647-H654.","DOI":"10.1152\/ajpheart.2001.281.2.H647"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Brilla CG, Pick R, Tan LB, Janicki JS, Weber KT: Remodeling of the rat right and left ventricles in experimental hypertension. Circ Res<\/i> 1990; 67<\/b>: 1355-1364.","DOI":"10.1161\/01.RES.67.6.1355"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Roussoulieres AL, Raisky O, Chalabreysse L, et al<\/i>: Identification and characterization of two genes (MIP-1β, VE-CADHERIN) implicated in acute rejection in human heart transplantation: use of murine models in tandem with cDNA arrays. Circulation<\/i> 2005; 111<\/b>: 2636-2644.","DOI":"10.1161\/CIRCULATIONAHA.104.482612"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2002.2088"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Solomon SD, Pfeffer MA: Aldosterone antagonism and myocardial infarction. From animals to man and back. J Am Coll Cardiol<\/i> 2003; 42<\/b>: 1674-1676.","DOI":"10.1016\/j.jacc.2003.08.008"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Zannad F, Alla F, Dousset B, Perez A, Pitt B, RALES Investigators: Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: insights from the Randomized Aldactone Evaluation Study (RALES). Circulation<\/i> 2000; 102<\/b>: 2700-2706.","DOI":"10.1161\/01.CIR.102.22.2700"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000039104.56479.42"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.05.003"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000074225.62168.68"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200317664"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Foo RSY, Mani K, Kitsis RN: Death begets failure in the heart. J Clin Invest<\/i> 2005; 115<\/b>: 565-571.","DOI":"10.1172\/JCI24569"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Cesselli D, Jakoniuk I, Barlucchi L, et al<\/i>: Oxidative stress−mediated cardiac cell death is a major determinant of ventricular dysfunction and failure in dog dilated cardiomyopathy. Circ Res<\/i> 2001; 89<\/b>: 279-286.","DOI":"10.1161\/hh1501.094115"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Chandrashekhar Y, Sen S, Anway R, Shuros A, Anand I: Long-term caspase inhibition ameliorates apoptosis, reduces myocardial troponin-I cleavage, protects left ventricular function, and attenuates remodeling in rats with myocardial infarction. J Am Coll Cardiol<\/i> 2004; 43<\/b>: 295-301.","DOI":"10.1016\/j.jacc.2003.09.026"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Leri A, Claudio PP, Li Q, et al<\/i>: Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell. J Clin Invest<\/i> 1998; 101<\/b>: 1326-1342.","DOI":"10.1172\/JCI316"},{"issue":"2","key":"38","first-page":"650","volume":"240","year":"1987","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3565","issn-type":"print"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Silvestre JS, Heymes C, Oubenaissa A, et al<\/i>: Activation of cardiac aldosterone production in rat myocardial infarction. Effect of angiotensin II receptor blockade and role in cardiac fibrosis. Circulation<\/i> 1999; 99<\/b>: 2694-2701.","DOI":"10.1161\/01.CIR.99.20.2694"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Katada J, Meguro T, Saito H, et al<\/i>: Persistent cardiac aldosterone synthesis in angiotensin II type 1A receptor−knockout mice after myocardial infarction. Circulation<\/i> 2005; 111<\/b>: 2157-2164.","DOI":"10.1161\/01.CIR.0000163562.82134.8E"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Funder JW, Pearce PT, Smith R, Smith AI: Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated. Science<\/i> 1988; 242<\/b>: 986-989.","DOI":"10.1126\/science.2845584"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Sheppard KE, Autelitano DJ: 11β-Hydroxysteroid dehydrogenase 1 transforms 11-dehydrocorticosterone into transcriptionally active glucocorticoid in neonatal rat heart. Endocrinology<\/i> 2002; 143<\/b>: 198-204.","DOI":"10.1210\/en.143.1.198"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Lombes M, Oblin ME, Gasc JM, Baulieu EE, Farman N, Bonvalet JP: Immunohistochemical and biochemical evidence for a cardiovascular mineralocorticoid receptor. Circ Res<\/i> 1992; 71<\/b>: 503-510.","DOI":"10.1161\/01.RES.71.3.503"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Young M, Fullerton M, Dilley R, Funder J: Mineralocorticoids, hypertension, and cardiac fibrosis. J Clin Invest<\/i> 1994; 93<\/b>: 2578-2583.","DOI":"10.1172\/JCI117269"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1210\/en.137.10.4145"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000080521.15238.E5"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47. Nagata K, Obata K, Xu J, et al<\/i>: Mineralocorticoid receptor antagonism attenuates cardiac hypertrophy and failure in low-aldosterone hypertensive rats. Hypertension<\/i> 2006; 47<\/b>: 656-664.","DOI":"10.1161\/01.HYP.0000203772.78696.67"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48. Konishi A, Tazawa C, Miki Y, et al<\/i>: The possible roles of mineralocorticoid receptor and 11β-hydroxysteroid dehydrogenase type 2 in cardiac fibrosis in the spontaneously hypertensive rat. J Steroid Biochem Mol Biol<\/i> 2003; 85<\/b>: 439-442.","DOI":"10.1016\/S0960-0760(03)00198-5"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49. Castren M, Trapp T, Berninger B, Castren E, Holsboer F: Transcriptional induction of rat mineralocorticoid receptor gene in neurones by corticosteroids. J Mol Endocrinol<\/i> 1995; 14<\/b>: 285-293.","DOI":"10.1677\/jme.0.0140285"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50. Lister K, Autelitano DJ, Jenkins A, Hannan RD, Sheppard KE: Cross talk between corticosteroids and alpha-adrenergic signalling augments cardiomyocyte hypertrophy: a possible role for SGK1. Cardiovasc Res<\/i> 2006; 70<\/b>: 555-565.","DOI":"10.1016\/j.cardiores.2006.02.010"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1210\/en.138.11.4912"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.207.293"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53. Fukushima K, Funayama Y, Yonezawa H, et al<\/i>: Aldosterone enhances 11β-hydroxysteroid dehydrogenase type 2 expression in colonic epithelial cells in vivo<\/i>. Scand J Gastroenterol<\/i> 2005; 40<\/b>: 850-857.","DOI":"10.1080\/00365520510015700"}],"container-title":["Hypertension Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T21:33:05Z","timestamp":1556573585000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nature.com\/doifinder\/10.1291\/hypres.30.427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":53,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007]]}},"URL":"https:\/\/doi.org\/10.1291\/hypres.30.427","relation":{},"ISSN":["0916-9636","1348-4214"],"issn-type":[{"value":"0916-9636","type":"print"},{"value":"1348-4214","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}