{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T08:49:35Z","timestamp":1771663775599,"version":"3.50.1"},"reference-count":39,"publisher":"Japanese Society of Hypertension","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hypertens Res"],"published-print":{"date-parts":[[2008]]},"DOI":"10.1291\/hypres.31.1407","type":"journal-article","created":{"date-parts":[[2008,10,29]],"date-time":"2008-10-29T05:58:55Z","timestamp":1225259935000},"page":"1407-1413","source":"Crossref","is-referenced-by-count":24,"title":["Possible Involvement of Rho-Kinase in Aldosterone-Induced Vascular Smooth Muscle Cell Remodeling"],"prefix":"10.1291","volume":"31","author":[{"given":"Kayoko","family":"MIYATA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"HITOMI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"GUO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-Xing","family":"ZHANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoji","family":"KIMURA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyasu","family":"KIYOMOTO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohisa","family":"HOSOMI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoji","family":"KAGAMI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakazu","family":"KOHNO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"NISHIYAMA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"119","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(99)70298-2"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Pitt B, Zannad F, Remme WJ, et al<\/i>: The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med<\/i> 1999; 341<\/b>: 709-717.","DOI":"10.1056\/NEJM199909023411001"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030207"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Takeda Y: Vascular synthesis of aldosterone: role in hypertension. Mol Cell Endocrinol<\/i> 2004; 217<\/b>: 75-79.","DOI":"10.1016\/j.mce.2003.10.012"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.28.447"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Muiesan ML, Rizzoni D, Salvetti M, et al<\/i>: Structural changes in small resistance arteries and left ventricular geometry in patients with primary and secondary hypertension. J Hypertens<\/i> 2002; 20<\/b>: 1439-1444.","DOI":"10.1097\/00004872-200207000-00032"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Park JB, Schiffrin EL: ET(A) receptor antagonist prevents blood pressure elevation and vascular remodeling in aldosterone-infused rats. Hypertension<\/i> 2001; 37<\/b>: 1444-1449.","DOI":"10.1161\/01.HYP.37.6.1444"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000039328.33137.6C"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000128031.31572.a3"},{"issue":"1 Pt.2","key":"10","first-page":"451","volume":"31","year":"1998","ISSN":"https:\/\/id.crossref.org\/issn\/0194-911X","issn-type":"print"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1161\/hc3001.091458"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Brown JH, Del Re DP, Sussman MA: The Rac and Rho hall of fame: a decade of hypertrophic signaling hits. Circ Res<\/i> 2006; 98<\/b>: 730-742.","DOI":"10.1161\/01.RES.0000216039.75913.9e"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Loirand G, Guerin P, Pacaud P: Rho kinases in cardiovascular physiology and pathophysiology. Circ Res<\/i> 2006; 98<\/b>: 322-334.","DOI":"10.1161\/01.RES.0000201960.04223.3c"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.27.263"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000107196.21335.2B"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000096650.91688.28"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000153316.59262.79"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.28.925"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005121375"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. van Nieuw Amerongen GP, van Hinsbergh VW: Cytoskeletal effects of rho-like small guanine nucleotide-binding proteins in the vascular system. Arterioscler Thromb Vasc Biol<\/i> 2001; 21<\/b>: 300-311.","DOI":"10.1161\/01.ATV.21.3.300"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000172622.51973.f5"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1124\/mol.65.4.832"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Salhia B, Rutten F, Nakada M, et al<\/i>: Inhibition of Rho-kinase affects astrocytoma morphology, motility, and invasion through activation of Rac1. Cancer Res<\/i> 2005; 65<\/b>: 8792-8800.","DOI":"10.1158\/0008-5472.CAN-05-0160"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.091264"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Adami R, Cintio O, Trombetta G, Choquet D, Grazi E: On the stiffness of the natural actin filament decorated with alexa fluor tropomyosin. Biophys Chem<\/i> 2003; 104<\/b>: 469-476.","DOI":"10.1016\/S0301-4622(03)00036-X"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.29.211"},{"issue":"5","key":"27","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/S0026-895X(24)26508-1","volume":"57","author":"ISHIZAKI T","year":"2000","ISSN":"https:\/\/id.crossref.org\/issn\/0026-895X","issn-type":"print"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Safar ME, Henry O, Meaume S: Aortic pulse wave velocity: an independent marker of cardiovascular risk. Am J Geriatr Cardiol<\/i> 2002; 11<\/b>: 295-298.","DOI":"10.1111\/j.1076-7460.2002.00695.x"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M005505200"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005050572"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Nishiguchi F, Fukui R, Hoshiga M, et al<\/i>: Different migratory and proliferative properties of smooth muscle cells of coronary and femoral artery. Atherosclerosis<\/i> 2003; 171<\/b>: 39-47.","DOI":"10.1016\/j.atherosclerosis.2003.08.007"},{"issue":"5","key":"32","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1093\/oxfordjournals.jbchem.a022806","volume":"128","author":"KISHI H","year":"2000","ISSN":"https:\/\/id.crossref.org\/issn\/0021-924X","issn-type":"print"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Kiian I, Tkachuk N, Haller H, Dumler I: Urokinase-induced migration of human vascular smooth muscle cells requires coupling of the small GTPases RhoA and Rac1 to the Tyk2\/PI3-K signalling pathway. Thromb Haemost<\/i> 2003; 89<\/b>: 904-914.","DOI":"10.1055\/s-0037-1613478"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Seasholtz TM, Majumdar M, Kaplan DD, Brown JH: Rho and Rho kinase mediate thrombin-stimulated vascular smooth muscle cell DNA synthesis and migration. Circ Res<\/i> 1999; 84<\/b>: 1186-1193.","DOI":"10.1161\/01.RES.84.10.1186"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Fu M, Zhang J, Tseng YH, et al<\/i>: Rad GTPase attenuates vascular lesion formation by inhibition of vascular smooth muscle cell migration. Circulation<\/i> 2005; 111<\/b>: 1071-1077.","DOI":"10.1161\/01.CIR.0000156439.55349.AD"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Liu Y, Suzuki YJ, Day RM, Fanburg BL: Rho kinase−induced nuclear translocation of ERK1\/ERK2 in smooth muscle cell mitogenesis caused by serotonin. Circ Res<\/i> 2004; 95<\/b>: 579-586.","DOI":"10.1161\/01.RES.0000141428.53262.a4"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Menard J, Gonzalez MF, Guyene TT, Bissery A: Investigation of aldosterone-synthase inhibition in rats. J Hypertens<\/i> 2006; 24<\/b>: 1157-1163.","DOI":"10.1097\/01.hjh.0000226205.65442.f2"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.27.303"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.27.781"}],"container-title":["Hypertension Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T08:24:22Z","timestamp":1738484662000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nature.com\/doifinder\/10.1291\/hypres.31.1407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":39,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1291\/hypres.31.1407","relation":{},"ISSN":["0916-9636","1348-4214"],"issn-type":[{"value":"0916-9636","type":"print"},{"value":"1348-4214","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}