{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:11:25Z","timestamp":1790655085904,"version":"4.1.0"},"reference-count":29,"publisher":"Japanese Society of Hypertension","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hypertens Res"],"published-print":{"date-parts":[[2008]]},"DOI":"10.1291\/hypres.31.1811","type":"journal-article","created":{"date-parts":[[2008,10,30]],"date-time":"2008-10-30T01:58:16Z","timestamp":1225331896000},"page":"1811-1820","source":"Crossref","is-referenced-by-count":44,"title":["Aldosterone Enhances Ligand-Stimulated Nitric Oxide Production in Endothelial Cells"],"prefix":"10.1291","volume":"31","author":[{"given":"Akiko","family":"MUTOH","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"ISSHIKI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiro","family":"FUJITA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"119","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Pitt B, Zannad F, Remme WJ, et al<\/i>: The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med<\/i> 1999; 341<\/b>: 709-717.","DOI":"10.1056\/NEJM199909023411001"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Farquharson CA, Struthers AD: Spironolactone increases nitric oxide bioactivity, improves endothelial vasodilator dysfunction, and suppresses vascular angiotensin I\/angiotensin II conversion in patients with chronic heart failure. Circulation<\/i> 2000; 101<\/b>: 594-597.","DOI":"10.1161\/01.CIR.101.6.594"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030207"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Losel RM, Falkenstein E, Feuring M, et al<\/i>: Nongenomic steroid action: controversies, questions, and answers. Physiol Rev<\/i> 2003; 83<\/b>: 965-1016.","DOI":"10.1152\/physrev.00003.2003"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.27.781"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.19.10500"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Gekle M, Silbernagl S, Wunsch S: Non-genomic action of the mineralocorticoid aldosterone on cytosolic sodium in cultured kidney cells. J Physiol<\/i> 1998; 511<\/b>: 255-263.","DOI":"10.1111\/j.1469-7793.1998.255bi.x"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Mihailidou AS, Buhagiar KA, Rasmussen HH: Na+<\/sup> influx and Na+<\/sup>-K+<\/sup> pump activation during short-term exposure of cardiac myocytes to aldosterone. Am J Physiol<\/i> 1998; 274<\/b>: C175-C181.","DOI":"10.1152\/ajpcell.1998.274.1.C175"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000093188.53554.44"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Schneider M, Ulsenheimer A, Christ M, et al<\/i>: Nongenomic effects of aldosterone on intracellular calcium in porcine endothelial cells. Am J Physiol<\/i> 1997; 272<\/b>: E616-E620.","DOI":"10.1152\/ajpendo.1997.272.4.E616"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Alzamora R, Michea L, Marusic ET: Role of 11beta-hydroxysteroid dehydrogenase in nongenomic aldosterone effects in human arteries. Hypertension<\/i> 2000; 35<\/b>: 1099-1104.","DOI":"10.1161\/01.HYP.35.5.1099"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Schiffrin EL: Effects of aldosterone on the vasculature. Hypertension<\/i> 2006; 47<\/b>: 312-318.","DOI":"10.1161\/01.HYP.0000201443.63240.a7"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Skott O, Uhrenholt TR, Schjerning J, et al<\/i>: Rapid actions of aldosterone in vascular health and disease—friend or foe? Pharmacol Ther<\/i> 2006; 111<\/b>: 495-507.","DOI":"10.1016\/j.pharmthera.2005.10.010"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Wehling M, Neylon CB, Fullerton M, et al<\/i>: Nongenomic effects of aldosterone on intracellular Ca2+<\/sup> in vascular smooth muscle cells. Circ Res<\/i> 1995; 76<\/b>: 973-979.","DOI":"10.1161\/01.RES.76.6.973"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.1771"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1130"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000083982.74108.54"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000106135.02935.E1"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Romagni P, Rossi F, Guerrini L, et al<\/i>: Aldosterone induces contraction of the resistance arteries in man. Atherosclerosis<\/i> 2003; 166<\/b>: 345-349.","DOI":"10.1016\/S0021-9150(02)00363-5"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000083298.23119.16"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Isshiki M, Mutoh A, Fujita T: Subcortical Ca2+<\/sup> waves sneaking under the plasma membrane in endothelial cells. Circ Res<\/i> 2004; 95<\/b>: e11-e21.","DOI":"10.1161\/01.RES.0000138447.81133.98"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.2484"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Bredt DS, Hwang PM, Glatt CE, et al<\/i>: Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature<\/i> 1991; 351<\/b>: 714-718.","DOI":"10.1038\/351714a0"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1161\/hh1101.092677"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000128022.24598.4f"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000244108.30909.27"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Sampaio WO, Souza dos Santos RA, Faria-Silva R, et al<\/i>: Angiotensin-(1−7)<\/NOBR> through receptor Mas mediates endothelial nitric oxide synthase activation via<\/i> Akt-dependent pathways. Hypertension<\/i> 2007; 49<\/b>: 185-192.","DOI":"10.1161\/01.HYP.0000251865.35728.2f"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Motley ED, Eguchi K, Patterson MM, et al<\/i>: Mechanism of endothelial nitric oxide synthase phosphorylation and activation by thrombin. Hypertension<\/i> 2007; 49<\/b>: 577-583.","DOI":"10.1161\/01.HYP.0000255954.80025.34"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000226054.53527.bb"}],"container-title":["Hypertension Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T20:29:12Z","timestamp":1557865752000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nature.com\/doifinder\/10.1291\/hypres.31.1811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1291\/hypres.31.1811","relation":{},"ISSN":["0916-9636","1348-4214"],"issn-type":[{"value":"0916-9636","type":"print"},{"value":"1348-4214","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}